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Influence of fetal microchimerism on breast carcinoma in mothers
Šůchová, Anna-Marie ; Hromadníková, Ilona (advisor) ; Balounová, Jana (referee)
Fetal microchimerism is a condition where fetal cells are present in the body of the mother, they are transmitted during pregnancy and may persist for several decades after parturition. Their presence affects the immune system of the mother, which is investigated in both autoimmune and tumor diseases. This work, as a literature review, summarizes the current knowledge of the effect of fetal microchimerism on breast carcinomas in mothers, which is one of the most common cancer in women worldwide. It is based on studies that examined the presence of fetal cells in peripheral blood and neoplastic maternal tissues. While the correlation between the presence of fetal microchimerism in peripheral blood and breast cancer suggests a possible protective role, the data on the investigation of the same correlation in neoplastic tissue are not so unambiguous. Some of them suggest a protective role, others have a negative role. Key words - fetal microchimerism, breast carcinoma, pathogenesis, oncology, tumor
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Specification of nutrition a patients with oncological disaeses of blood.
MACHOVCOVÁ, Denisa
A common problem with oncological diseases is a lack of nutrition or refusal to take food caused by changes in taste or other complications associated with treatment. This is also true with oncological blood diseases. Because of the influence of their treatment, the people with these diseases frequently lose their appetite and suffer from nausea, often strong enough to induce vomiting, as well as diarrhea or complete change of taste. Immediately after the treatment they can feel a so called "metallic" taste in the mouth. This thesis focuses on analyzing whether the intake is sufficient in such cases. For qualitative research, we used directive interview and collected anthropometric data and sample menus from respondents with oncological blood diseases, which are subsequently calculated Nutriservis. The interview focused primarily on nutrition, but there were also some questions about treatment, as well as family and personal medical history. Comparing the documented menus from the respondents with the calculated values of the recommended intake for each person had a predictable result. All respondents had a lower intake of energy than was calculated for them Protein was taken by 77.7% people (i.e., 7 out of 9 people), which is also a small amount, while fat was taken by 44.4% (4 of 9 people), which is larger amount than recommended. None of the respondents achieved the recommended amount of carbohydrates. We can therefore say that, despite the efforts of doctors and nutritional therapists, people with oncological blood diseases still suffer from poor nutrition. This situation can only be prevented by giving the people with these diseases enough information about the frequent complications that occur and the risks associated with them. In addition, it is necessary to monitor these people and, in cases of major weight loss, inform their doctor, who will consider the administration of artificial nutrition.
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Modeling and Signal Processing in Dynamic Contrast Enhanced Magnetic Resonance Imaging
Kratochvíla, Jiří ; Šroubek,, Filip (referee) ; Tintěra,, Jaroslav (referee) ; Jiřík, Radovan (advisor)
The theoretical part of this work describes perfusion analysis of dynamic contrast enhanced magnetic resonance imaging from data acquisition to estimation of perfusion parameters. The main application fields are oncology, cardiology and neurology. The thesis is focused on quantitative perfusion analysis, specifically it contributes to solving of the the main challenge of this method – correct estimation of the contrast-agent concentration sequence in the arterial input of the region of interest (arterial input function). The goals of the thesis are stated based on literature review and on the expertise of our group. Blind deconvolution is selected as the method of choice. In the practical part of this thesis, a new method for arterial input function identification based on blind deconvolution is proposed. The method is designed for both preclinical and clinical applications. It was validated on synthetic, preclinical and clinical data. Furthermore, possibilities of the longer temporal sampling provided by blind deconvolution were analyzed. This can be used for improved spatial resolution and possibly for higher SNR. For easier deployment of the proposed methods into clinical and preclinical use, a software tool for perfusion data processing was designed.
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Nursing Problems of Patients with Skin Cancer
CHLÁDKOVÁ, Anežka
The character of oncological diseases can be benign or malignant. Both variants have fundamental consequences for the patient. If the changes in the skin are malignant, treatment is necessary. In case the medical finding is benign, it depends on the patient whether the tumour would have it removed or not. In any case, the patient must be informed about all risks and especially the dispensarisation which is the most significant factor for early diagnosis and effective treatment. Oncological disease of skin entails many significant changes in the patient's life. The patient's order of values, lifestyle, as well as perception of life changes. In this difficult situation, the support of the patients from the side of family and loved ones, as well as of the medical personnel, is crucial. The patient's need of security and safety must be satisfied, as it is a significant factor in coping with the disease development from diagnostics to treatment and eventual dying. The concept of the bachelor thesis is theoretical and based on the study and analysis of information sources related to the issues of oncological disease of skin. To introduce the largest and very important organ the skin its anatomy and physiology is briefly described at the beginning. Subsequently, oncological diseases of skin, divided into benign tumours, their variants and characteristics, are outlined. The subchapter of malign tumours lists the most frequent malignant skin tumours, i.e. basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. Again, their characteristic and seriousness is described. Diagnostics and therapy of oncological diseases of skin is worth mentioning. The prognosis of the entire disease depends on early diagnostics. If it is timely, the treatment is less demanding and the patient handles it much better. In the area of therapy, the most frequent methods of treating this disease are illustrated. In connection with this disease, it is important to mention dispensarisation and prevention, oncological and palliative care as well as the impact of the disease on the patient's psychic condition. The bachelor thesis is complemented with supplements in the form of tables. One of them refers to incidence, mortality and prevalence of malignant melanoma from 1994 to 2014. Other tables serve for easier understanding of classification of skin tumours. The objective of the thesis was to map the nursing care of oncological diseases of skin. A nurse is an important element of prevention. She can be helpful and educate the population about self-monitoring of skin. During the treatment, the nurse applies medicaments and treats skin after surgical procedures or radiotherapy. The nurse plays an essential role within oncological and palliative care. That is why her relevance is described in several chapters. For many patients, the support of the nursing staff is a very important factor also in the area of psychic condition, on which the approach to the disease, as well as the development of the treatment, are based. It was necessary to acquire many findings about oncological diseases of skin to write this thesis. Many experts are engaged in this area nowadays, especially in the area of treatment. Information was obtained from both Czech and foreign expert bibliographic publications and articles. The studied information is incorporated into individual chapters that can be beneficial for anyone who is engaged in this specific area of oncology.
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Tumours in historical and social context in the modern period
Hrudka, Jan ; Komárek, Stanislav (advisor) ; Tinková, Daniela (referee) ; Stingl, Josef (referee)
Univerzita Karlova v Praze Přírodovědecká fakulta Studijní program: Filosofie a dějiny přírodních věd MUDr. Jan Hrudka Nádory v dějinném a kulturním kontextu v novověku Tumours in historical and social context in the modern period Disertační práce Školitel / Supervisor: Prof. RNDr. Stanislav Komárek, Dr. Praha, 2017 SUMMARY: The PhD thesis called Tumours in historical and social context in the modern period is an attempt to describe a change of medical thinking in modern period; science and medicine turns from antique humoral pathology, explaining all diseases as an imbalance of the four body humours, to pathological anatomy and experimental physiology. In the point of view of pathological anatomy, the viscera of diseased person are no more "screen" or "mirror" of the disease, but it becomes directly the "stage" or "theatre" of the acting disease. This shift in the thought may be labelled as movement from humoralism to localism or ontologism; the disease isn't just abnormal amount of some natural juice any more, but becomes new original entity. This change undergoes the understanding of tumours and cancerous disease as well. Instead of antique understanding tumours as precipitates of black bile, the cell theory occurs in the 19th century. This theory explains tumours as a mass of cells undergoing excessive...
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Patient education on oncology orthopedics
Grymová, Renata ; Vachková, Eva (advisor) ; Švecová, Dagmar (referee)
Author: Renata Grymová Institution: Institute of social medicine Faculty of medicine in Hradec Kralove Nursing care department Name of theses: Patient education on oncology orthopedics Head of theses: Mgr. Eva Vachková, Ph.D Number of pages: 124 Number of attachments: 8 Year of deffence: 2014 Summary: Bachalor thesis is focusing on education of patient in oncological orthopedic ward. This thesis consists of two parts: theoretical and empirical. Theoretical part deals with the issue of education, oncological orthopedic, chemotherapy administrating, competences of nurses working in oncological orthopedic ward and educational topics in oncological orthopedics. Empirical part consists of questionnaire that is supposed to find out patients perception of illness, interpretation of all dialogues with respondents and also interpretaion of fulfilled aims of this bachalor theses. Key words: oncology, ortophedics, patients, education, chemotherapy
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Determination of selenium and manganese in cerebrospinal fluid by atomic absorption spectrometry
Jiráková, Lucie ; Kotaška, Karel (advisor) ; Klapková, Eva (referee)
The aim of this study was to confirm the use of electrothermal atomic absorption spectrometry for the determination of selenium and manganese in the cerebrospinal fluid and to investigate concentrations of selenium and manganese in selected group of patients. For selenium was determined the detection limit 2,9 μg/l, for manganese 0,26 μg/l. 73 patients were examined (31 women, 42 men) whose average age was 14,1 years. The patients were divided into two groups according to age (56 children, 17 adults) and into two subgroups according to diagnoses (oncological, neurological). The control group consists of 18 subjects (5 women, 13 men, average age 21,7 years) with non-oncological and non-neurological diagnoses. We found significantly increased selenium concentrations in cerebrospinal fluid in the control group, compared with the group with neurological diagnoses (median = 14,4 μg/l vs. 12,4 μg/l, p < 0.05). Elevated levels of manganese in cerebrospinal fluid was observed in a group of children with oncological diseases compared with control group (1,2 μg/l vs. 0,5 μg/l, p < 0.05). Determination of selenium and manganese in the cerebrospinal fluid may have diagnostic importance in selected groups of patients. Powered by TCPDF (www.tcpdf.org)
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Enteral nutrition in oncology patients
Šulcová, Jana ; Křížová, Jarmila (advisor) ; Mráz, Miloš (referee)
This bachelor thesis considers possibilities of enteral nutrition and its influence on life quality of oncological patients. The thesis consists of a theoretical and an experimental part. The theoretical part compiles the issue of malnutrition and nutritional support with emphasis on enteral nutrition. It deals with malnutrition in oncology and its solution. In the experimental part, a study of influence of enteral nutrition on life quality of oncological patients was conducted. A question was, how health condition, life quality and energy intake of patients are changed after one month of enteral nutrition use. The survey includes a physical examination, measuring patients with a machine Bodystat Quadscan 4000, filling up a questionnaire, evaluation of laboratory tests, and analysis of the patient's diet. The results of the study prove positive influence of enteral nutrition on health condition of patients with respect to laboratory tests. According to the questionnaire, the life quality of patients increased and the diet report shows increased energy intake. The physical examination results and Bodystat measurements did not prove positive influence of enteral nutrition.
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