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Ionic fields of various kinds and method of measurement.
Gubani, Ondřej ; Vaněk, Jiří (referee) ; Vognar, Jiří (advisor)
In the air there are positively and negatively charged ions with different mobility and size. The therapeutic effect of negative ions with high mobility is known. High concentration of negative ions occurs in speleotherapic caves. This bachelor thesis introduces the methods of measuring the concentration and mobility of various kinds of ions and their evaluation by spectral characteristics. It verifies the current mirror effect on the ions´ concentration in space. It also examines the effect of different types of ions in living organisms and an appropriate area treatment for the occurrence of negative ions.
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The Role of Lipid Rafts in Translocation of the Adenylate Cyclase Toxin of B. pertussis across Cytoplasmatic Membrane
Chvojková, Věra ; Gahura, Ondřej (referee) ; Šebo, Peter (advisor)
The bacterium Bordetella pertussis is the causative agent of pertussis or whooping cough. The main virulent factor of this gram-negative bacterium is adenylate cyclase toxin, a member of the RTX protein family. After secretion, the toxin binds to CD11b/CD18 integrin receptor of myeloid phagocytic cells and consequently translocates its adenylate cyclase enzyme (AC) into the cytosol of the host cells. In the cytosol, the AC is activated by calmodulin, followed by rapid conversion of ATP into the signaling molecule cAMP, resulting in paralysis of bactericidal functions of phagocytic cells. Recently it was shown that translocation of the catalytic AC domain into the cytosol proceeds in two steps. After binding of CyaA to the receptor, the influx of calcium ions into the cell occurs. High local concentration of calcium induces the translocation of the CyaA- CD11b/CD18 complex into the lipid raft, where the translocation of adenylate cyclase enzyme into cytosol occurs. This work is aiming on the description of the new established paradigm dealing with membrane translocation of RTX toxins.
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Determinants of Industrialization in sub-Saharan Africa and Possibilities for their Development
Sejkora, Jiří ; Jiránková, Martina (advisor) ; Šaroch, Stanislav (referee) ; Fárek, Jiří (referee) ; Adamcová, Lenka (referee)
Sub-Saharan economies need structural changes that would enhance their productivity, increase economic growth and development. In this regard, industrialization plays a key role. Using regression analysis, the aim of this dissertation thesis is to identify main factors (determinants) of industrialization in sub-Saharan Africa. The results indicate that infrastructure and economy size (measured by population size) represent main determinants of industrialization in the region. The thesis also deals with possibilities for development of those determinants. Case study of infrastructure development in Mauritius emphasizes privatization, cooperation with external subjects etc. Negative consequences of small economy size can be overcome by preferential trade agreements (under certain circumstances), as shown by analysis of the three smallest economies in the region.
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financial analysis of hotel
Kondrashov, Alexey ; Petrů, Zdenka (advisor) ; Indrová, Jarmila (referee)
This Master's thesis is focused on financial analysis of joint-stock company Recoop Tour for the period 2004-2007, which owns one of the luxury hotels in Prague Diplomat. This hotel has a rich tradition of providing accommodation and catering services, the organization of international symposia, fairs and conferences. The company Recoop Tour is attractive for the purposes of financial analysis because it is a relatively new corporation, which was actually created for the construction and operation of one of the most luxurious hotels in Prague. The company uses a bank loans from its very beginning and therefore has negative equity. However, the results of economic activity show a continuous reduction of negative values of foreign capital. Development of indices of financial analysis suggests that the situation in corporate finances needs to adopt a number of measures such as a raise of common stock and certain other management decisions, which will increase the overall performance and achievement of economic profit.
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Congenital disorders by cattle
KOSOBUDOVÁ, Hana
In the framework of this thesis was performed genotyping of 46 specimens of the breed Czech red cattle from the University farm in Czech Budejovice, which monitored the incidence of autosomal recessive genetic disorders, specifically bovine citrullinemia (BC) in exon 5 and deficiency of blood coagulation factor XI (FXI) in exon 9 and 12. Genotyping for BC was done using PCR/RFLP methods and for the disorder FXI in both exons genotypes were determined on the basis of different length of fragments using PCR technology and horizontal agarose electrophoresis. The presence of mutant allele was detected only in the locus for BC and that is in 7 heterozygous carriers, who produced three bands with a length of 185 bp fragments, 103 bp and 82 bp. The frequency of mutant allele and the frequency of heterozygous carriers to 7.6% and 15.2%. Results of the study show that the presence of mutant allele for BC in our tested panel of animals is relatively high. In the future it will be necessary to adopt measures that will lead to the elimination of this allele. Otherwise, its further dissemination would have a negative impact on the health of the population and there might occur complications in the regeneration of Czech red cattle, which is one of our farm animal genetic resources. The literature review deals with the problems of congenital disorders and discusses the importance of health heredity and understanding of the genomic information of cattle.
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Irish political parties euroscepticism analysis
Chrudimská, Barbora ; Šlosarčík, Ivo (advisor) ; Kasáková, Zuzana (referee)
Ireland is generally seen as one of the biggest supporters of the European Union. Irish public opinion researches have been showing long-term and extremely positive attitudes to the European integration. The pro-European consensus is also known among the local political parties. Moreover, at the end of the 20th century, a strong economic growth had started and the Ireland quickly became a model example of how positive impact the European integration may have on its Member states. European issues therefore did not attract too much attention in the local political discourse. This changed in the early 21st century, when the increasing public euroscepticism began observable. The thesis examines whether selected Irish political parties adapted their rhetoric and actions to ever more critical mood of voters. These are Fianna Fáil, Fine Gael and the Green Party. The thesis covers three critical moments of the Irish European integration, namely the Nice Treaty, the Lisbon Treaty and the Irish debt crisis. It searches for negative comments about the EU and European integration of examined political parties in the campaigns before the referendum on European issues, as well as in their election statements to the Irish parliamentary elections, also taking place in the selected period. The aim of the thesis is...
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Cannabis - history and present
Skokanová, Tereza ; Hubertová, Lucie (advisor) ; Klimešová, Anna (referee)
My work is about history of cannabis, about positive size of this plant, about negative size of this plant and about the antidrug politic size against this plant. My work is consists of five main parts. I am starting to talk about history of those plants and I am trying to introduce you with this plants. The second part is about positive size of cannabis plant. The basic positive of cannabis is healing effects and use in the agriculture as well in an industry. The third part is opositte of second part so I will be talking about negative size of cannabis. We know that cannabis has healing power but in my work I will show you danger and harmfulness of cannabis on the users. The fourth part is about antidrug policy against cannabis. Mostly I will talk about OSN because they are one of the biggest antidrug policy on the world. Still we going to talk about antidrug policy in an Europe Unie and of course in the Czech Republic. Last part of my work is a research which is focus on students in Czech Republic and their sentiment about cannabis.
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The Development of Mimetic Desire towards Latent Conflict in the Work of Katherine Mansfield
Nováčková, Zuzana ; Wallace, Clare (advisor) ; Nováková, Soňa (referee)
Thesis abstract Using Aristotelian notion of imitative behaviour and René Girard's theory of mimetic desire, several stories by Katherine Mansfield are analysed in order to demonstrate the development of mimetic desire together with its implications. The analysis follows the negative aspects of mimesis: the problems it causes in relationships, as well as the positive aspects including the self-knowledge. Since Mansfield's stories do not correspond fully to Girard's theory, the analysis explores a specific way of dealing with mimetic desire: keeping the conflict latent. At first, the stories about childhood offer an insight into Aristotelian concept of mimesis - imitative behaviour being a natural and pleasing human activity that is best observed in children's plays. The stories show how children choose their models, how they comprehend the world that surrounds them, especially the interpersonal and social codes, and how important is imagination in their mimetic activities. The analysis proceeds from natural imitation to the origins of mimetic desire, focusing on two modes of mediation and on the process of realization of one's own self-authenticity. The search for self-authenticity is possible due to external or internal mediation of desire. The transition from one type to the other is explained by the...
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The performance of the Czech Private Pension scheme: Current design and its position within CEE countries
Hlaváč, Jan ; Schneider, Ondřej (advisor) ; Benáček, Vladimír (referee)
This thesis focuses on the comparison of financial performance of the Czech voluntary private pension scheme with five other reformed private pension schemes in the region of Central Eastern Europe (Bulgaria, Croatia, Hungary, Poland and Slovak Republic). The current state and the recent development of the Czech private pension scheme are analyzed in the first part of the thesis. In the main part of this work we construct the dataset of periodic scheme returns covering the last decade, and estimate the schemes Sharpe ratios (SR) for four reference benchmarks. To complement the analysis we also employ the Sharpe style analysis to evaluate the impact of managerial decisions of market selection/timing on the scheme returns. The findings suggest that except for Poland none of the schemes managed to beat its long- term domestic benchmark (10- year government bonds) as the SRs estimates turn out to be negative. The highest underperformance was found in the case of Czech Republic. The results of style analysis suggest a modest positive influence of the active managerial decisions on the scheme returns with respect to the passive investment strategies. JEL Classification G23, G28, O57, H55 Keywords: Private pension schemes, Czech voluntary pension scheme, financial performance, Sharpe ratio, Sharpe Style...
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Margins of Trade: Czech Firms Before, During and After the Crisis
Galuščák,Kamil ; Sutóris, Ivan
We investigate the extensive and intensive margins of trade of Czech firms in periods before, during and after the crisis of 2008–2009. The intensive margin explains most of the aggregate export growth in 2006–2014, which corroborates previous findings for other countries. The contribution of the extensive margin is smaller, explaining on average 39% of the aggregate export growth in 2006–2007 and around 25% to 30% of that in the post-crisis period. The lower contribution of the extensive margin may signal a lower rate of convergence of the Czech economy. The results indicate that the crisis had a more severe impact on small exporting firms and that exports to countries outside the EU gained more prominence in the post-crisis years. Our results are similar to findings from previous studies on the impact of participation in global value chains on firms’ trade. Specifically, a more negative impact of the crisis was observed for exports with higher import intensity. Overall, our results point to the importance of using disaggregated data in the analysis of countries’ export performance.
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