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Validity of predictive equations for determining resting energy expenditure
Fabián, Patrik ; Korvas, Pavel (referee) ; Chlíbková, Daniela (advisor)
This bachelor thesis deals with the validation of predictive equations to determine resting metabolic rate. The objective of this bachelor thesis was to compare individual predictive equations for determining resting metabolic rate with self-measurement using indirect caloriemetry and to establish a own procedure for predicting resting metabolic rate. The evaluation of each predictive equation was based on statistical analyses. Based on statistical analyses, it was found that the available predictive equations underestimate resting metabolism by an average of 20 % of kilocalories per day compared to the value measured by indirect calorimetry. Machine learning was used to determine the actual procedure for predicting resting metabolic rate, which was then presented using the user interface. The following testing showed that the neural network for predicting resting metabolic rate provides more accurate results compared to the available predictive equations.
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Resting energy expenditure and nutritional intake in patients with pancreatic cancer before elective pancreatectomy
Heniková, Marina ; Gojda, Jan (advisor) ; Urbánek, Miroslav (referee)
Aims: The aim of this work was to determine whether a increased resting energy expenditure contributes to the nutritional risk for patients with pancreatic cancer. What the variability of resting energy expenditure is and whether it predicts weight loss. Another aim was to verify that lower protein-energy intake also has an impact on weight loss. Methods: Data for the diploma thesis were obtained from the project "Pancreatic Cancer: Metabolic Derangements Associated With Insulin Resistance", which takes place at the Department of Clinical Physiology of Metabolism at 2nd Department of internal medicine in the University Hospital Královské Vinohrady. The project includes 40 - 50 patients with pancreatic tumor resection per year. Data were collected from the beginning of December 2019 until the end of April 2020. The project is funded by the grant AZV NV19-01-00101. 10 consecutive patients (4 women and 6 men) with pancreatic cancer who had a complete dataset for analysis were selected for the research set for the diploma thesis. The patients underwent anthropometric examination, blood tests were taken, and indirect calorimetry was performed. Results: The first part of the research was focused on anthropometric parameters, parameters of nutritional status and the presence of cancer cachexia. The second...
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Nutritional Status in Patients with Huntington's Disease and Nutritional Support
Kosheleva, Svetlana ; Klempíř, Jiří (advisor) ; Růžičková, Lucie (referee)
Huntington's disease is a dominantly-inherited autosomal neurodegenerative disease manifested by disorders of motility, cognitive function, behaviour, and weight loss, which is conditioned multifactorially. The aim of the study was to determine whether there are eating disorders in Huntington's disease, as well as its etiology and severity. Neurological scaling, anthropometric examinations, evaluation of three-day diet records, measurements with a manual dynamometer, bioimpedance analyses, indirect colorimetry and predictions of energy expenditure were performed on 10 patients. Algorithms were applied for the diagnosis of sarcopenia and malnutrition. Unwanted weight loss was observed in all patients and 4 out of 10 showed malnutrition. No difference was found between the values of measured resting metabolism and calculated according to the predictive equation. However, it has been shown that strict nutritional recommendations based on this data can be misleading for some patients with HN, as real energy consumption can be significantly higher. All our patients had a positive energy balance. A new diagnostic algorithm for the early diagnosis of sarcopenia has proven its worth. Using bioimpedance analysis and examination of the force of the handshake, we identified possible sarcopenia and already-present...
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Movement economy and physiological response during differing climbing speeds in sport climbers
Podoba, Peter ; Baláš, Jiří (advisor) ; Heller, Jan (referee)
Title: Movement economy and physiological response during differing climbing speeds in sport climbers. Aims: The work aims to evaluace climbing economy and physiological responses of intermediate and advanced climbers in different climbing speeds. Methodology: 32 climbers (11 advanced men, 11 intermediate men, 10 intermediate women) performed 3 submaximal tests in treadwall at slope of 90ř at speeds 4, 6 and 9 m.min-1 . Each of the tests lasted exactly 4 minutes. Oxygen consumption (VO2), heart rate (HR), ventilation (VE), respiratory ratio (RER) and energy expenditure were monitored. Results: Advanced men reported lower energy expenditure than intermediate men in all climbing speeds (4 m.min-1 : -0,06 kcal.kg-1 , P = 0,007; 6 m.min-1 : -0,06 kcal.kg-1 P = 0,048; 9 m.min-1 : -0,07 kcal.kg-1 P = 0,022). Intermediate women reported only slightly lower energy expenditure than intermediate men (4 m.min-1 : -0,01 kcal.kg-1 P = 0,051; 6 m.min-1 : 0,06 kcal.kg-1 P = 0,091; 9 m.min-1 : -0,03 kcal.kg-1 P = 0,115). Energy expenditure was significantly lower at 4 m.min-1 than at 6 m.min-1 (-9,82 kcal, p = 0,001) and also signicantly lower at 6 m.min-1 than at 9 m.min-1 (-8,3 kcal, p = 0,001). Advanced men reported significantly lower VO2 at speeds 4 a 6 m.min-1 (- 2,2 ml.kg- 1 .min-1, P = 0,022; -3,9 ml.kg-1...
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Effect of lower limb length-bike rime size relationship on psychophysilogocal response of the organism
Sukovič, Richard ; Brtník, Tomáš (advisor) ; Šafránek, Jiří (referee)
VLIV VZTAHU DÉLKY DOLNÍ KONČETINY A VELIKOSTI RÁFKU NA PSYCHOFZIOLOGICKOU ODEZVU ORGANISMU Cíle: Cílem této práce je posoudit vliv délky dolní končetiny (DK) na psychofyziologickou odezvu organismu při jízdě na horském kole s odlišnými velikostmi ráfků. Metody: Soubor probandů tvořilo 20 mužů ve věku 26,4 ± 4,2 let. Jednalo se o experiment. Psychofyziologická odezva byla stanovena na základě výkonu (zajetého času), tepové frekvence a subjektivním hodnocení jízdních vlastností horského kola a vlastního vynaloženého úsilí hodnoceného na Borgově škále. Ke kontrolní analýze při testování byl použit přístroj MetaMax 3B. Testovány byly tři velikosti ráfků o stejné šíři plášťů. Jízdy byly realizovány na 800 m dlouhém okruhu. Testované osoby absolvovali každou jízdu s individuálně zvoleným fixním převodem v poloze v sedle s maximálním možným úsilím. Výsledky: Při jízdě na různě velkých ráfcích jsme u skupiny č. 2 (85 -90 cm DK) shledali velký rozdíl (P = 0,016) v dosažených časech při jízdě na různě velkých ráfcích. U skupiny č. 1 jsme shledali významné rozdíly v průměrné tepové frekvenci (P = 0,010), který činil 3 tepy a u subjektivního hodnocení vlastního vynaloženého úsilí pomocí Borgovy škály jsme se pohybovali na hranici významnosti (P = 0,060). Skupina č. 3 (97 - 101 cm DK) se pohybovala na hranici...
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Indirect calorimetry in patients with home parenteral nutrition
Neradová, Andrea ; Meisnerová, Eva (advisor) ; Ševela, Stanislav (referee)
Introduction: Establishing the energy expenditure of patients with home parenteral nutrition (HPN) is a key component of nutritional care, just as important as being aware of how HPN affects energy expenditure. This helps prevent complications associated with excessive or insufficient nutrition. Certain studies have aimed at these issues have been carried out around the world, but little attention has been devoted to this subject in the Czech Republic as of yet. Several methods of ascertaining energy expenditure exist, with indirect calorimetry being considered the gold standard, however, in practice, various predictive equations are predominantly used instead. Aims: To compare the difference between the base metabolic rate (BMR) and the resting energy expenditure (REE) in patients with home parenteral nutrition. When measuring REE, to also establish the extent of the thermic effect of parenteral nutrition. Furthermore, to compare the results for energy expenditure (BMR, REE) obtained via indirect calorimetry with the results obtained via the frequently used predictive equations for calculating BMR and REE, and to ascertain which predictive equation most closely matched the measurements obtained via indirect calorimetry. Methodology: Outpatients with HPN seen at the 4th internal clinic of the...
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Comparison of methods of basal metabolism determination
Kosková, Martina ; Coufalová, Klára (advisor) ; Hráský, Pavel (referee)
Title: Comparison of individual methods of basal metabolism determination Objectives: The aim of the work is to compare the individual methods of basal metabolism. These values were measured by indirect calorimetry, plethysmography, bioelectric impedance and predictive equations. Methods: The research was attended by 31 people, including eight men and twenty-three women. All participants of my research were aged 21-30 years. None of the participants was a professional athlete, they were all healthy and none of the women were pregnant or had menstruation. The indirect calorimetry, bioelectronics impedance device Tanita MC - 980 and BOD POD were used to collect the data. Basal metabolic rates were calculated from the prediction equations by Harris & Benedict, Fleisch's equation and Schofield's equation using measured anthropometric values. Results: The results of the methods that have been used for this group of people vary, but the difference is not significant. If we choose as a reference method indirect calorimetry, we can't replace it by any other method. The results for other methods are not significantly different, so we can replace one method with another, except indirect calorimetry. From calculations, we also found out that fat free mass greatly influences the results of basal metabolic rate...
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Effect fo different sizes of wheels of in-line skates on energy expenditure
Sukovič, Richard ; Jindra, Matouš (advisor) ; Brtník, Tomáš (referee)
EFFECT OF DIFFERENT SIZES OF WHEELS OF IN-LINE SKATES ON ENERGY EXPENDITURE Objectives: The aim of this bachelor thesis is to determine the difference in energy expenditure when using different sizes of wheels of in-line skates. Methods: The research group consisted of 5 people in age 26,4 ± 2,2 years. This was an experiment. The calculation of energy expediture was based on the amount of oxygen consumption (VO2) and exhaled carbon dioxide (VCO2), i.e. indirect calorimetry. For the analysis of respiratory gases MetaMax 3B measuring device was used. Three sizes of wheels of the same hardness were tested. The rides were carried out on a 1,5 km section of a cycle path with the effect of the height difference of 2 mm/m. Probands completed one test ride (with a cadence of 70 rpm) on each size set of wheels. Test ride lasted for 5 minutes. For results were processed values of 3 minutes steady state VO2. Results: We found out a noticeable difference in energy output between 72 mm and 90 mm large wheels. The difference between driving on 72 mm and 80 mm large wheels and driving on 80 mm and 90 mm large wheels was, due to the standard error of measurement, insignificatnt. Conclusion: The energy expenditure reached a noticeable increase in driving with a larger diameter of wheels compared to driving on...
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Assessment of the Resting Energy Expenditure in Obese Individuals
Sadílková, Aneta ; Matoulek, Martin (advisor) ; Vilikus, Zdeněk (referee)
Introduction: Weight loss programs are based on inducing a negative energy balance by decreasing energy intake while increasing energy expenditure. Energy needs of obese patients are difficult to determine. The value of resting energy expenditure, as the largest component of the energy needs, is usually calculated to asses an adequate energy intake for obese patient. In clinical practice, predictive equations are most commonly used for this purpose, because of their simplicity, although many clinical studies have shown that in obese individuals they may generate errors large enough to impact the outcome of treatment. It leads to the prescription of an inadequate diet that does not meet the criterion of long-term sustainability. Objective: The aim of the thesis is to compare the values of resting energy expenditure (REE) measured by indirect calorimetry with values calculated with Harris-Benedict predictive equation in a selected group of obese individuals. Methods: The sample includes 38 subjects, 28 women and 10 men, patients of the General University Hospital in Prague. The average age is 48 ± 11,71 years, the mean BMI is 42,88 ± 9,09 kg/m2 . For each subject, resting energy expenditure was measured by indirect calorimetry and calculated by the Harris-Benedict predictive equation. Indirect...
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Body composition parameters in dependence on the metabolism degree in patients with COPD
Doleželová, Magdaléna ; Kovařík, Miroslav (advisor) ; Hronek, Miloslav (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Student: Magdaléna Doleželová Supervisor of master thesis: PharmDr. Miroslav Kovařík, Ph.D. Title of master thesis: Body composition parameters in dependence on the metabolism degrese in patiens with COPD Chronic Obstructive Pulmonary Disease (COPD) is a very serious illness characterized by incompletely reversible airflow obstruction and lung emphysema. Contributes to its overall severity are extrapulmonary manifestations, especially cachexia and loss of lean tissue mass. Chronic inflammation of the respiratory airways and increased respiratory effort cause the hypermetabolic state to some patients with COPD. This thesis investigates the impact of increased metabolism on body composition in patients with COPD. Our study included 50 COPD patients (38 men, 12 women) who were examined by bioelectrical impedance. In this study, we compared the parameters of body composition of men with resting energy expenditure REE > 130% (hereinafter Men over 130%) (n = 9) and the group of men with REE < 130 % (hereinafter Men below 130 %) (n = 29). In the group of Men over 130 % we found a lower average value of body weight by 18 % compared to Men below 130 %. Total body and intracellular water were 12 %...
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