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New regulatory metabolic factors in patients with obesity and type 2 diabetes mellitus
Matějková, Mirka ; Haluzík, Martin (advisor) ; Flachs, Pavel (referee)
Fibroblast growth factors are proteins with diverse biological function in development, tissue repair, and metabolism. The human FGF gene family consists of 22 members. FGF 19 subfamily includes FGF 19, FGF 21, and FGF 23. They act as systemic factors in an endocrine manner. FGF 19 subfamily requires klotho protein as a cofactor for its action. FGF 19 produced by intestine acts mainly in the liver through FGFR4, where it inhibits bile acid and fatty acid synthesis. FGF 21 is produced by the liver and contributes to the regulation of carbohydrate and lipid metabolism through modulation of glucose uptake in adipocytes. Serum FGF 21 levels are increased in patients with obesity and type 2 diabetes mellitus. Serum FGF 19 levels are on the contrary decreased in patients with obesity and type 2 diabetes mellitus and more probably depend on the nutritional status of the organism than on the glucose metabolism and insulin sensitivity. Key words: type 2 diabetes mellitus, FGF 19, FGF 21, obesity, adipose tissue
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Low carbohydrate diet in type 2 diabetes mellitus therapy
Kábelová, Adéla ; Krejčí, Hana (advisor) ; Šeda, Ondřej (referee)
Type 2 diabetes mellitus (T2D) is a highly prevalent metabolic disorder, which substantially affects quality of patients' lives and simultaneously increases the risk of early death due to development of its specific complications. Current T2D therapy comprises mainly pharmacotherapy, however, lifestyle changes, particularly modification of dietary habits, also assume an important role in the process. While conventional dietotherapy of T2D primarily concerns reduction of dietary fat intake aiming to achieve caloric restriction, the low carbohydrate diet (LCD), recently often discussed in relation to T2D therapy, is based on the reduction of dietary carbohydrates, whereas fats and/or proteins are increased. The positive effects of LCD in T2D therapy and its comorbidities are summarized in the theoretical part of this thesis. The aim of the practical part of the bachelor thesis was to asses the effect of LCD on health parameters associated with T2D as well as the subjective sense of respondents' satisfaction with this diet together with their adherence and compliance. The results of the survey showed that LCD led to weight loss, decreased waist circumference, glycaemia and levels of glycated haemoglobin and led, in a number of cases, to medication reduction. The level of satisfaction with LCD in the...
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Recent trends in therapy of diabetes mellitus type II
Boučková, Karolína ; Herink, Josef (advisor) ; Vopršalová, Marie (referee)
The bachelor's thesis is adressed to diabetes mellitus type 2, the lifestyle disease. It characterizes all its kinds, the laboratory diagnostics and complications. The thesis also contains causes of its appereance, risk factors and clinical manifestations. Nowadays the disease is growing enormously, it strikes people of different ages and genders. That is why the selection of therapy is very important. Particular attention is paid to a standart therapy but also to the latest trends within pharmacological and non-pharmacological treatments. Thanks to suitable therapy and upholding the treatment plan patients can live their life to the full. Key words: diabetes mellitus type 2, clinical symptoms, therapy
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Prevention of complications of 2nd type insulin-dependent diabetes mellitus
Fabianová, Monika ; Eislerová, Iva (advisor) ; Kvasnička, Tomáš (referee)
Bachelor thesis is focused at preventing complications in patients with 2nd type insulin-dependent diabetes mellitus. The aim of the final work was to determine complications associated with the basic disease, prevention of complications, patient education and awareness about diabetes and regime measures. Research was conducted in outpatient clinics for diabetics and subjects of research were 100 adult patients with 2nd type insulin-dependent diabetes mellitus. Research conducted on the basis of a questionnaire survey. The theoretical part focused on basic information about diabetes mellitus in particular classification, diagnosis, treatment, complications, prevention and treatment of disease complications. The practical part was focused on patients with diabetes and activity based on the questionnaire the data were analyzed and graphically processed using tables and graphs. The work showed the results of many research deficiencies in patient awareness and proper education. Many patients do not realize the severity of the disease and the consequences of underestimating the preventive measures. Key words: 2nd type diabetes mellitus, diabetic complications, hypoglycaemia, diabetic foot, prevention of complications, treatment of diabetes, risk factors, insulin treatment.
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LCD a VLCD diet during hospitalization
Zajíčková, Jana ; Matoulek, Martin (advisor) ; Kytnarová, Jitka (referee)
Objective: LCD and VLCD diets are short-term indicated (days to weeks) low caloric and very low caloric diets, which should be supervised by a doctor - e. g. by means a weight loss hospitalization (WLH). LCD and VLCD diets are used in preoperative preparation of obese patients and to break insulin resistance in patients with type 2 diabetes mellitus (DM II). The theoretical part of the bachelor"s thesis is focused on LCD and VLCD in obesity and diabetes mellitus treatment - the two most common diseases that can be found in the medical history of patients indicated for WLH. The aim of the theoretical part is to compare obesity treatment in medical care and commercial weight loss programs (for commercial weight loss programs the term "obesity management" is used). The study evaluate the most common indications for WLH, determine weight changes during the hospitalization and compare the weight of patients with DM II and without DM II (nDM II) one year after the WLH. Methods: The input data were obtained from the Medea database. These are the anamnestic data of patients hospitalized for the purpose of losing weight on the Third Medical Department of First Faculty of Medicine Charles University and General University Hospital in Prague in the period of January 2014 - January 2015. There were 93 WLHs...
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The role of mitochondria in the pathogenesis
Marková, Lenka ; Doležal, Pavel (advisor) ; Verner, Zdeněk (referee)
This thesis is focused on the existing data referring to role of mitochondria in the pathogenesis of several important diseases. It introduces mitochondrial proteins, their role and metabolism, dysfunction of which is behind pathogenetic processes. The thesis also summarizes possible mitochondrial damage, its progress and consequences, which can lead to diseases or aggravate their process. It also pays attention to the role of mitochondria during oncogenesis as well as important neurodegenerative disorders such as Alzheimer's or Parkinson's disease, Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis or autosomal dominant optic atrophy. The thesis mentions the role of disrupted mitochondrial dynamics in type 2 Diabetes. In conclusion the thesis mentions the role of mitochondria and their damage in relation to infection by the parasites Toxoplasma gondii and Trypanosoma cruzi.
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The Influence of a Lifestyle of Women with Anamnesis of Gestational Diabetes Mellitus on Manifestation of Diabetes Mellitus Type 2
Dittrichová, Jana ; Anderlová, Kateřina (advisor) ; Krejčí, Hana (referee)
1 Abstract: The present thesis is focused on a lifestyle of women with anamnesis of Gestational Diabetes and on the way in which this lifestyle influences manifestation of Type 2 Diabetes. The goal of the thesis is to describe the ways in which women with anamnesis of Gestational Diabetes in the period 1-11 years after delivery behave preventively in order that Type 2 Diabetes would not occur - to describe their diet and movement activities as well as to discover, if they have their blood sugar level checked regularly. By means of questionnaire survey, it has been discovered that women with anamnesis of Gestational Diabetes consume not-sweetened beverages, coffee, vegetable and fruits, on the other hand it would be convenient, if they would eliminate secondary processed food, red meat, sweets and fried meal and increase intake of nuts, fish and cereals. 83 % of women engage in a movement activity at least 3 times a week. 52 % had come for blood sugar level examination (oGTT) after delivery and another 12 % had their blood sugar level checked during regular medical examination. Nevertheless, many respondents are not regularly monitored anymore. Women with anamnesis of Gestational Diabetes, in the case of which blood sugar level examination (oGTT) detected Prediabetes or Type 2 Diabetes, consume too much...
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The role of nutritional therapist in education of patients with type 2 diabetes
Erban, David ; Škrha, Jan (advisor) ; Krátký, Jan (referee)
Aim of thesis: The research aimed to evaluate the importance of individual education by a clinical dietitian and compare it to information brochures only. Methods: 52 patients with type 2 diabetes from the Third Department of Internal Medicine of the General Hospital in Prague were selected for the research. Totally, 48 of them finished the research. These patients were divided into two groups. Group A was educated individually by a clinical dietitian. This group consisted of 27 patients, of which 13 were men and 14 were women. Group B was educated using a brochure only. This group consisted of 21 patients, of which 11 were men and 10 were women. Both groups were given the questionnaire before the education and then 4 months after the education. Additionally, glycated haemoglobin was measured in patients before the education and then 4 months after the education, during the next visit to their diabetologist. Results: In both groups, some improvement was observed after the education. Either in knowledge or their levels of glycated haemoglobin. In group A, the education had better cognitive results in all questions of the questionnaire except for one. Levels of glycated haemoglobin decreased by 9,4 in men and by 4,8 mmol/mol in women in group A. In group B, education did not affect the knowledge of...
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Effects of n-3 polyunsaturated fatty acids on development of non-alcoholic fatty liver disease in experiment, prevalence in patients with type 2 diabetes mellitus and metabolic syndrome, non-invasive diagnostics
Dvořák, Karel ; Brůha, Radan (advisor) ; Ehrmann, Jiří (referee) ; Lotková, Halka (referee)
This thesis focuses on the effects of n-3 polyunsaturated fatty acids (n-3 PUFA) on development of non-alcoholic fatty liver disease (NAFLD) in experiment, on prevalence of this condition in patients with type 2 diabetes mellitus and metabolic syndrome and also on non-invasive diagnostics. The aim was to study the effect of n-3 PUFA on NAFLD development in an experimental model and based on analysis of a group of patients with type 2 diabetes and metabolic syndrome to assess the prevalence of this condition. Lastly we aimed to evaluate non-invasive diagnostic methods of liver fibrosis and NASH. We demonstrated beneficial effects of n-3 PUFA administration on NAFLD development in a C57/Bl6 mice high fat methionin-cholin defficient dietary model of NAFLD. n-3 PUFA administration led to biochemical improvement, decrease of lipid accumulation in the liver as well as improvement of histology. These effects are determined by complex modulation of lipid metabolism, mainly due to decrease in availability of fatty acids for triglyceride synthesis in the liver, changes of adipokine levels and amelioration of proinflammatory status in the liver. In a group of type 2 diabetics we found NAFLD prevalence of almost 80%, 14% of these patients had also signs of liver fibrosis or cirrhosis. Non-invasive methods...
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