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Disinfection by-products originating from pesticides
Plachá, Markéta ; Načeradská, Jana (advisor) ; Kopecká, Ivana (referee)
An important step in the treatment of drinking water is disinfection, which serves to remove pathogenic substances. During this process, disinfection by-products can be formed, which are mainly produced from organic natural substances reacting with the disinfectant. However, treated water may also contain anthropogenic substances, such as pesticides, whose disinfection by-products are the subject of this work. From the accessible data of the studies carried out so far, a basic summary of their creation was created, and characteristic properties that are essential for the evaluation of adverse effects on human health and the environment. From the field of organophosphorus pesticides, it was found that pesticides containing a phosphorothioate part can be easily oxidized by chlorine to the corresponding oxone derivative, while organophosphorus pesticides with a phosphate part are very stable in the presence of chlorine. The resulting oxon forms can be more effective inhibitors of acetylcholinesterase than their parent compounds and at the same time be stable enough (more than 24 h) to reach the consumer, on whom they can, however, have a negative effect. At the same time, disinfection by- products from pesticides can be more toxic than the original compounds. These include chloroxon, diazoxon and...
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Evaluation of zolpidem tartrate using HPLC
Kopecká, Iva ; Pilařová, Pavla (advisor) ; Kastner, Petr (referee)
Charles University in Praque, Faculty of Pharmacy in Hradci Králové Department: Pharmaceutical Chemistry and Drug Control Candidate: Iva Kopecká Tutor: PharmDr. Pavla Pilařová, Ph.D. Name of Degree Paper: Evaluation of zolpidem tartrate using HPLC In the diploma thesis, there was optimazed the method of separation of zolpidem tartrate and its impurity A. There was tested the influence of the composition of the mobile phase, molarity of phosphate buffer, its pH and the temperature on the column. The optimal conditions of the separation were determined - methanol:acetonitril: 0,06 mol/l phosphate buffer pH 4 (20:15:65), the temperature on the column 30řC, the flow rate of the mobile phase was 1ml/min and the detection in the UV in the wavelength of 254 nm. Afterwards, the method was used for rating of stability tests in these load conditions - alkaline environment, increased temperature, oxidative environment and daylight. The decrease of the concentration of effective substance of zolpidem tartrate in the given environment and time was observed as well as the potential development of the destructive products of the effective substance.
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Basic population register in relation to administration information systems: Data sharing in public administration Czech republic
Kopecká, Iveta ; Vlasák, Rudolf (advisor) ; Lipková, Helena (referee)
The work analyzes the current status of the basic population register in relation to agenda information systems. The theoretical part is focused on basic registers in general with a particular attention being paid to the population register. The analytical part examines in detail the current status of all configured and implemented processes that have a direct impact on the functionality of the basic population register in relation to agenda information systems and subsequent data sharing in the public administration of the Czech Republic. Attention is focused on the use and provision of reference data through Web services and information system of basic registers. The paper also analyzes the various approaches of agenda information systems of public authorities to basic Population Register and the implementation of sub-projects that have a direct impact on its operation. Evaluation of individual areas assessed is done using a statistical survey.
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Chromatographic evaluation of amiodarone and its active metabolite
Kopecká, Iva ; Pilařová, Pavla (advisor) ; Kastner, Petr (referee)
77 Abstract Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Mgr. Iva Kopecká Tutor: PharmDr. Pavla Pilařová, Ph.D. Name of Degree Paper: Chromatographic evaluation of amiodaronu and its active metabolite The main purpose of this thesis was to optimize the existing HPLC method used in University Hospital Hradec Králové for determination of amiodarone and its active metabolite in biological material. For this HPLC method was used Waters Symetry C18 column, 150 x 4,6 mm, 5 µm, mobile phase: acetonitrile: 25 mM phosphate buffer (55:45), flow rate 1,4 ml/min, at 45 ř C, injection 5 µl, UV detection at 242 nm. This method was subsequently transferred to a UHPLC using Phenomenex Kinetex C18 column, 100 x 2,1 mm, 1,7 µm, mobile phase: acetonitrile: 25 mM phosphate buffer (55:45), flow rate 0,3 ml/min, at 45 ř C, injection 5 µl, UV detection at 242 nm. This UHPLC method was modified for eventual detection by mass detector using same UHPLC column, mobile phase: acetonitrile: 0,1% formic acid (55:45), flow rate 0,3 ml/min, at 45 ř C, injection 5 µl, UV detection at 242 nm. At the same time plasma, resp. serum sample isolation was optimized. The best result was achieved by adding 4 µl of 10% zinc sulfate to the plasma sample...
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Applied Mineralogy in Forensic Science field
Kotrlý, Marek ; Matějka, Dobroslav (advisor) ; Kopecká, Ivana (referee) ; Vojtíšek, Pavel (referee)
1 ABSTRACT Surprisingly, applied mineralogy plays an important role in the forensic science field. It is the miner- alogical phases which exist in many kinds of materials and traces but also the mineralogical analysis procedures which are often used in the field of so called trace evidence. For purposes of this study, 4 important fields of forensic microanalysis were chosen. These are those fields in which applied min- eralogy is applied and which characterize the width and heterogeneity of the concerned area. Powder X-ray microdiffraction plays quite an important and irreplaceable role not only in the direct phase analysis of substances in mixtures. The author designed, tested and introduced a set for centra- tion and direct check of the analysed surface during micro-diffraction analysis and also experimentally optimised sensing parameters for the different system configuration. A possibility to calculate the size of the nanoparticles (more precisely the size of a mono crystal domain) was tested. XRD methods ap- plication allows refining organic analysis for example in the case of new synthetic drugs. Micro diffrac- tion was also used for the first complex phase analysis of colour layers of the altar in the chapel in the castle of Křivoklát (dated 1480 - 1490). Forensic analysis of soil phases used to be,...
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Strategic Brand Development
Kopecká, Irina ; Mráček, Pavel (referee) ; Zich, Robert (advisor)
The diploma thesis focuses on the strategic development of the brand of the selected winery Znovín Znojmo. The work is divided into three parts. The theoretical part defines the market, customers, competitors, brand, brand identity and communication mix. The second part of the work is the analytical part, which aims to evaluate the current situation of the company and determine possible steps to develop the brand. The last part of the diploma thesis is a recommendation based on knowledge gained from the first parts for the strategic development of the brand.
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Adsorption of organic compounds onto activated carbon in water treatment process
Kopecká, Ivana
The dissertation thesis focuses on the application of activated carbon for the removal of low molecular weight algal organic matter (AOM) produced by phytoplankton during drinking water treatment, as well as on the effect of AOM on adsorption of anthropogenic micropollutants contained in raw water. The results of this study have been published in international peer-reviewed journals in 4 papers and in 2 conference contributions. The efficiency of AOM removal was studied in laboratory equilibrium and kinetic experiments using different types of granular activated carbon and cellular peptides with molecular weight < 10 kDa produced by cyanobacterium Microcystis aeruginosa. It has been previously confirmed that these peptides are removed with difficulty during the conventional water treatment based on coagulation/flocculation processes and therefore, other methods need to be applied for their restriction. The effect of solution properties on peptide adsorption was assessed by the tests at different pH values and at variable ionic strengths. The negative impact of peptides on the adsorption of organic micropollutants present in raw water was simulated using competitive adsorption experiments with herbicides alachlor and...
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