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Effectiveness and safety of selected dietary supplements
Smolíková, Kateřina ; Pokladníková, Jitka (advisor) ; Marešová, Helena (referee)
Effectiveness and safety of selected dietary supplements Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague Student: Kateřina Smolíková Tutor: PharmDr. Jitka Pokladníková, Ph.D. Introduction: The market for dietary supplements in recent years has seen a noticeable upswing and supplements become for some people part of their daily lives, which could mean potential risks. Objectives: To assess the effectiveness and risks of selected dietary supplements containing Vaccinium macrocarpon, Serenoa repens, Cimicifuga racemosa, Glycine max and Silybum marianum. At the same time, the aim of this work was to evaluate the safety of selected supplements from the point of view of content of additives, check undesirable effects of harmful additives and compare them with the identified undesirable effects of medicinal plants. Methods: Efficacy and safety were assessed on the basis of scientific studies. It has been rated 5 best-selling groups of food supplements in 2011. The list of 100 best-selling nutritional supplements in the Czech Republic were given to us by one pharmacy chain. From the most selling supplements was made a list of the most frequently occurring substances content which was sent to the Ministry of Health with a request to add...
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Advertising on complementary, alternative medicines and over the counter medicines (OTC) published in the printed journals for lay people from the view of Evidence Based Medicine
Schirlová, Zuzana ; Matoulková, Petra (advisor) ; Malý, Josef (referee)
Advertising on complementary, alternative medicines and over the counter medicines (OTC) published in the printed journals for lay people from the view of Evidence Based Medicine Student: Schirlová. Z Tutor: Matoulková, P. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic INTRODUCTION: Advertisements are important means of communicating information to public. The quality of the pharmaceutical advertising has been continuously discused. METHODS: The objective of the study was to assess availability of supporting scientific information for health claims stated in the food supplements and OTC (Over-the- Counter) medicines ads that were published during period September 2012 and June 2013 in the mostly read life style journals for women. For each advertisement, the emphasized claim/-s was compared to available scientific unbiased evidence. The literature search was conducted by using Pubmed database (mainly meta-analysis and randomized clinical trials). Further information was searched in the Scholar Google, Natural Medicines Comprehensive Database (Consumer version) and Micromedex. Different keywords and their appropriate combinations were used to identify relevant information. Frequency analysis was used to assess frequency...
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Safety of selected dietary supplements with regard to the content of food additives IV.
Tížková, Jana ; Pokladníková, Jitka (advisor) ; Marešová, Helena (referee)
DIPLOMA THESIS: Safety of selected dietary supplements with regard to the content of food additives SOCIAL AND CLINICAL PHARMACY DEPARTMENT, FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ, CHARLES UNIVERSITY IN PRAGUE AUTHOR: Jana Tížková SUPERVISOR: PharmDr. Jitka Pokladníková, Ph.D. INTRODUCTION: Usage of dietary supplements is increasing each year. But with this trend there are also concerns about their possible damaging influence, mostly due to present food additives. I have decided to map safety of dietary supplements from food additives point of view, because of spare information about their potential harmfulness. OBJECTIVE: Goal of this work is to evaluate safety of bestselling immune system support according to food additives that they contain and analysis of most commonly occurring harmful additives influence on human health. METHODOLOGY: List of bestselling dietary supplements was gathered from one of pharmaceutical chain brand. Data came from diverse list of dietary supplements, from which I have chosen those with supporting effect on immune system. They contain mostly substances gathered from Echinacea plants, specifically Echinacea angustifolia, pallida, purpurea, mushroom Pleurotus ostreatus, also those containing Probiotics, Royal jelly and mixture of oligosaccharides, nucleotides and...
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Opinions, knowledge, perception of risks and compliance of patients using non-prescription drugs and dietary supplements I.
Obrová, Hana ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Opinions, knowledge, perception of risks and compliance of patients using non-prescription drugs and dietary supplements I. Author: Hana Obrová1 Tutor: Josef Malý1 1 Department of Social and Clinical Pharmacy, Charles University in Pague, Faculty of Pharmacy in Hradec Králové Introduction: A part of the health knowledge everyone of us should be the self-medication. The assortment of OTC drugs and dietary supplements is still being spread in the Czech Republic. It carries benefits and risks. Objectives: The aim of the study was to investigate current opinions, attitudes and knowledge of patients from the Czech Republic about OTC drugs. Methods: The data were collected at the hospital in Svitavy and at the Department of occupational medicine in Svitavy. The interviews were performed in April and July 2013. The data were analysed and described by means of the frequency analysis in Microsoft Excel 2007. Results: The answers were obtained from 169 respondents (44,0 % women and 56,0 % men). The average age of the patients was 50 years. 54,0 % of the patients preferred self-medication before the visit of the doctor. 85,0 % of the patients used at least one OTC drug in the last year. 77,0 % of the patients agreed with the statement that the self-medication could have some risks. The...
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Strength training and influencing factors
Farkaš, Boris ; Bunc, Václav (advisor) ; Semerád, Miroslav (referee)
STRENGHT TRAINING AND INFLUENCING FACTORS Objectives: The aim of this thesis is to form, apply and find the influence of created workout regarding body composition changes. Methods: In this work we used bioimpedance analysis, antropomotorical measurements of muscle mass and diagnostics of previous physical experience. Results: Considering the following measurement we found out significant changes in fat mass and muscle mass ratio as well as increase of muscle mass in upper extremities. Keyowords: muscle strenght, adaptation, muscle hypertrophy, fat loss, dietary supplements, training programme
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Dietary supplements in sport nutrition
BOČAN, David
Thesis deals with dietary supplements and their use by amateurs and professionals.The theoretical part is in the 1st part devoted to supplements and their legislation,forms and division.To the 2nd part was selected substances used by athletes and further discussed in terms of their function and effects on the organism.Within the general information was drafted in the 3rd part risks related to the use of dietary supplements due to wrong dosage or concentration and the issue of doping. Research was conducted through a questionnaire survey among professionals and amateurs.Questionnaire was created on the server google.cz and distributed in electronically and printed form.Respondents were south in several ways.There were used personal contacts and sending questionnaires to sport clubs.Research group contained 166 respondents-83 amateurs and 83 professionals.For evaluation were used basic statistical tests-pivot tables and chi-square test.The processing of results was made in Microsoft Excel 2013. Besides aims to map the use of supplements by athletes were expressed two hypotheses. The 1st hypothesis: There are statistically significant differences in knowledge of supplements between amateur and professional athletes.The 2nd hypothesis:There are statistically significant differences in the use of supplements between amateur and professional athletes. The 1st hypothesis was rejected.There were no statistically significant differences in knowledge of supplements between amateurs and professionals.The 2nd hypothesis was dealt separately for four seasonsfor the period of preparation before exercise/after exercise and for the period of the season, again before exercise/after exercise.In periods of preparation (before and after exercise) and after exercise in the season, there were statistically significant differences in the use of supplements between amateurs and professionals. In these cases 2nd hypothesis was confirmed.In the period of seasonbefore exercise was hypothesis rejected. In this period was no statistically significant differences in the use of supplements between amateurs and professionals. In the next question they were asked about learning about supplements.Most of the information were received from teammate/colleague. In the next part were surveyed effects of various factors for the purchase of supplements on a scale of 0 points (least)-10 points (most influence). Price is a factor that rather affects athletes but more the group of amateurs.Quality has a great influence on both groups. The country of origin is a factor which has by amateurs the largest representation at the point 0. Professionals find it like rather affecting. Brand name is a factor in both groups rather affecting. The package (label) doesn't rather affects athletes,more on amateurs. Recommendations known and previous experience are important for both groups of athletes.The influence of habit is not clear, almost all points are represented by the same ratio of votes. Discount and advertising are factors that affect athletes rather not.Influence expert forums and reviews on amateurs is not clear, professionals voted the most mean value. The most common reasons for using supplements are for both groups regeneration, energy source,adding vitamins and joint nutrition.Amateurs monthly invest in the purchase of dietary supplements less (500 CZK),professionals 500 or 1000 CZK. The most preferred forms of supplements are tablets,powders,capsules and liquids,including beverages.Sticks and gels are used more by professionals. Most of respondents use supplements by recommendation exactly or rather. The most common place of purchase supplements are for professionals specialized stores and for both groups also the Internet. Thesis could serve as an information resource for athletes to clarify that dietary supplements should take depending on what they want to achieve.Also it could be used as study material for courses dealing with nutrition and sport.
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Recombinant probiotics
Surá, Tereza ; Rittich, Bohuslav (referee) ; Španová, Alena (advisor)
Theoretical part of this thesis focuses on present state and research of recombinant probiotics and their use in food industry and health care. It also concentrates on their beneficial effects on the health of individuals. The experimental part focuses on the identification of specific bacterial strain in a probiotics food supplements. The DNA was isolated from these products by use of magnetic microparticles and obtained DNA was subsequently analysed through polymerase chain reaction.
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Development of probiotic dietary supplement
Krahulcová, Aneta ; Vítová, Eva (referee) ; Vránová, Dana (advisor)
The thesis deals with a theme of probiotic mikroorganisms which are aplicated as a dietary supplement. Health benefit on the host have been known for a long time, however, there might be some negative effects affecting a consumer. In connection with this observation defining requirements and evaluating of safety of probiotics in food was necessary. The new probiotic dietary supplement can not be expanded on the market without these processes. Every strain must be tested separately on each property. The ability of rezistance against conditions inside human gastrointestinal tract belongs to the most basic tests. The aim of the practical part is testing this ability of rezistance in vitro by simulated conditions. The model of gastrointestinal juices was designed according to the Czechoslovak codex. The form contributes to the higher rezistance of probiotics within implementing to the host. Also a dosage form of probiotics was involved to a in vitro testing.
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