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The role of myelin plasticity in specific CNS functions - learning and memory, reward system
Pfeiferová, Diana ; Pivoňková, Helena (advisor) ; Kriška, Ján (referee)
Neuroplasticity is a fundamental characteristic of the brain that allows it to adapt to changes in the environment, learn new skills or recover from injuries. Although the majority of scientific literature on neuroplasticity has focused on neurons and synaptic changes, recent research suggests another important mechanism that is based on myelin plasticity. The goal of this bachelor thesis is to present a literature review on current research trends in the topic of myelin plasticity. The focus revolves around the function of myelin, the lipid membrane that provides insulation and support to axons, and the concept of myelination as an adaptive process. The relationship between activity-dependent myelination, its triggers, and the effect on specific brain circuits function and dysfunction are thoroughly discussed. Research in myelin plasticity has led to a change in the paradigm of brain plasticity, as there is now clear evidence that the latter cannot be fully understood without taking the former into account.
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Characterization of different differentiation protocols of H9c2 cardiomyoblasts
Gardianová, Anna ; Jirkovský, Eduard (advisor) ; Macháček, Miloslav (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Anna Gardianová Supervisor: PharmDr. Eduard Jirkovský, Ph.D. Title of diploma thesis: Characterization of different differentiation protocols of H9c2 cardiomyoblasts Cell differentiation is a common process in the development of multicellular organisms leading to an alteration of cell's appearance and function. The process of differentiation plays a significant role in the reparation of damaged tissues too. Some chemicals may have negative effects on these processes and therefore affect human health. This thesis focuses on characterization of differentiation processes of H9c2 cell line using various published differentiation protocols, and to describe changes over time in the morphology (occurrence of multinucleated and elongated cells) and mRNA expression of selected markers typical for the cardiac (cTnT, Hand2, GATA4) or skeletal (myogenin) muscle phenotype. We monitored the process of the differentiation for 15 days and the individual protocols differed by the addition of fetal bovine serum (FBS, 1 % or 10 %) and all-trans- retinoic acid (ATRA, 10 nmol/L) to the growth medium Dulbecco's Modified Eagle's Medium. From what we have observed, the results show that all of the utilized protocols...
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Differentiation Strategy of Small Company
Šteflová, Jitka ; Bečvářová, Soňa (referee) ; Koráb, Vojtěch (advisor)
The aim of the thesis is to propose effective and feasible strategy of differentiation. The thesis may be used as a valuable basis for developing a business plan founding or development of the company. According to the information processed in the theoretical part will be an analysis, whose outputs reveal the direction of future strategies and are the basis for the development of a differentiation strategy of small company, including the evaluation of potential risks and opportunities for future development.
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Supply proposal of a company
Chudoba, Filip ; Pavelka,, Vladimír (referee) ; Juřica, Pavel (advisor)
The master's thesis deals with possible adjustments in the company's inventory replenishment strategy, which are in accordance with the analyzed factors of the external and internal environment of the company and which respond to the problems arising in the input logistics processes in which this strategy is implemented. The proposed strategy adjustments bring a new perspective on inventory management through inventory optimization and categorization according to differentiated inventory management approach, even in relation to inventories that are subject to deterioration.
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Comparing flat prices in the Czech Republik and Slovakia
Šimášková, Ľubomíra ; Lorencová, Marie (referee) ; Superatová, Alena (advisor)
The objective of this Diploma Thesis is to benchmark prices of preselected types of flats in the Czech Republic and Slovakia. Main aim of this exercise is to examine the pricing rules in the Czech Republic and Slovakia. Other area of focus is to set prices for selected prices of flats in the suburb and in the city center of Brno and Bratislava and compare them with each other. Analyze which factors affect prices and how they differ from each other.
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Analysis of Competitors Fight in Business Technology Sector
Kreps, Jakub ; Špíšek, Jiří (referee) ; Bartes, František (advisor)
The thesis analyses competitive environment of suppliers of concurrent quality control technology in industrial enterprises and research laboratories. The thesis provides concepts for a creation of competitive advantages and related higher evaluation of costs and diferentiation than competition. Further it compares technologies from various manufacturers, comparing economical and technical parametres. The evaluation of results follows a presentation of approachs to achieve the most efficient competitors fight management. The thesis also include prognosis of future conditions in the business technology sector on Czech and Slovak market and concept of an appropriate format of effective competitive intelligence. In conclusion there is a presentation of a quality and quantity concept evaluation with emphasis on economic gain of presented solution.
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Proposal of the Family-owned Company Differentiation Strategy
Bělová, Zuzana ; Ing. Alena Hanzelková, Ph.D., MBA (referee) ; Koráb, Vojtěch (advisor)
This diploma thesis concerns in the first part on conditions for entrepreneurship in Spain and in Czech Republic. It also analyses current position of family companies in the hospitality industry, both spanish and czech. In the conclusion I suggest steps which should lead into growth of attendance of the czech brasserie, it´s bigger popularity and increase in effectivness. Finally, the implementation of such proposals in practice should mean higher customers‘ satisfaction.
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Proposal of Strateggy of Company
Sabaková, Nikola ; Mráček, Pavel (referee) ; Zich, Robert (advisor)
The content of this diploma thesis is to propose a business strategy for the newly established company, which will operate on the Czech market. The subject of the business is the operation of a special gastronomic facility created by combining two concepts of café and tea room with a focus on differentiation. The business strategy focuses on establishing a new company that defines its competitive behavior within the three-year horizon. Suggestions are focused on building a successful business and doing business to bring it a competitive advantage. On the basis of the analyzes conducted, they have computed competing enterprises, customers or internal business factors and will propose an appropriate company development strategy that will ensure its profitable prosperity. My goal is to create a unique, competitive and profitable business that meets all the requirements of its customers.
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Strategy of Company Development
Maršalová, Pavlína ; Kučera, Pavel (referee) ; Koráb, Vojtěch (advisor)
The purpose of this diploma thesis is a proposal strategy of company development for a business company XY s.r.o. Analysis conducted was aimed at research of internal company resources and external environment. The results of the analysis show market position and identifies source of competitive advantage. Strategy implementation should support improvement of market position.
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