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Mechanism of cancerogenic effect of nitroaromates pollutants in present environment
Čechová, Tereza ; Stiborová, Marie (advisor) ; Svobodová, Martina (referee)
Nitroaromatic compounds are mutagenic and carcinogenic substances present in all environmental compartments. Polycyclic aromatic hydrocarbons react with nitrogen oxides to form nitroaromatics under the conditions that might be expected in polluted air and in combustion processes (fossil fuel combustion, waste heat recovery, metal processing, etc.). Most of nitroaromatic compounds are potent mutagens in bacterial and mammalian systems. They are also carcinogens causing cancer, primarily in the liver, lungs and mammary glands. Nitrobenzanthrones (NBA) are nitroaromatic compounds which were recently found in environmental compartments, especially in the air. 3-Nitrobenzanthrone (3-NBA, 3-nitro-7H-benz [de] anthracene-7-one) is one of the polycyclic aromatic nitro compounds with high toxic effects. 3-NBA is present in environmental pollution, in diesel exhaust and was also detected in soil and in rain water. Bachelor's thesis describes the metabolism of this substance and it also studies its mutagenic and carcinogenic effects. This work also compares the mutagenic and carcinogenic effects of 3-NBA and its derivative, isomer 2-nitrobenzanthrone (2-NBA, 2-nitro-7H-benz [de] anthracene-7-one), which also occurs as a pollutant in air. (In Czech)
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Class climate
Svobodová, Martina ; Hejlová, Helena (advisor) ; Voda, Jan (referee)
The aim of this diploma thesis is to analyze the criteria of the school class climate quality, to deal with the role of the primary school teacher as a co-creator of the climate, with the requirements that are laid on the teacher and the required proffesional competences. The thesis also deals with analysis of the conditions that create the school climate from the pupils' point of view - especially the development compliance that originates from the dependence on the class composition. Another aim of the thesis is to describe issue of newly-made casses on the grounds of created relationships between the pupils both during and outside the lessons. The methods of educational survey and educational-psychological diagnosis were used.
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Flexible forms of work in the labour market of the Czech Republic. The case study of the function of offer and demand in the company
Svobodová, Martina ; Kuchař, Pavel (advisor) ; Tuček, Milan (referee)
The diploma thesis deals with flexible forms of work in the Czech Republic. After the short introduction of the history and theoretical frameworks, particular types of alternative work forms used in the Czech labour market are presented. Readers are faced with part-time jobs, flexible work hours, home office and other. Special part is dedicated to occupying of part-time workers who are employed in the mode of Contract of Services, which is specific for Czech labour market and is involved in flexible work forms in this text. The great part of this thesis occupies case study, which was held at headquarters of one Czech company and which provides view of function of flexible forms of work on the side of the employer and employees as well. Data analysis offers mainly information coming from perception of alternative working forms by their users, which means employees, but by provider as well. Emphasis is placed primarily on evaluation of motives which lead into implementing and demanding of flexible work forms and also their advantages and disadvantages. Readers can find in analytic part also profiling of group of employees working in alternative working modes. These profiles are built-up from the view of the character of employees positions and from their individual characteristics as well. It is also...
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Metabolism of carcinogenic o-nitroanisol and its metabolite o-nitrophenol and two environmental pollutants 2-nitrobenzanthrone and 3-nitrobenzanthrone
Svobodová, Martina ; Stiborová, Marie (advisor) ; Entlicher, Gustav (referee) ; Souček, Pavel (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF SCIENCE DEPARTMENT OF BIOCHEMISTRY Metabolism of carcinogenic o-nitroanisole, its metabolite o-nitrophenol and environmental pollutants 2-nitrobenzanthrone and 3-nitrobenzanthrone Summary of PhD Thesis RNDr. Martina Svobodová Supervisor: Prof. RNDr. Marie Stiborová, DrSc. Prague 2010 RNDr. Martina Svobodová Introduction -1- INTRODUCTION 2-Nitroanisole 2-Nitroanisole (2-methoxynitrobenzene, 2-NA, figure 1) is an important industrial pollutant and a strong carcinogen for rodents causing neoplastic transformation in the urinary bladder and, to a lesser extent, in the spleen, liver and kidney [19, 30, 31] . 2-NA is also a toxic compound, causing anemia. 2-NA is used primarily as a precursor in the synthesis of o-anisidine (2-methoxyaniline), which is an intermediate in the production of many azo dyes. This compound is used in pharmaceutical industry as an intermediate in the synthesis of some medicaments [30, 31] . In spite of potent rodent carcinogenicity of 2-NA, this chemical is weakly mutagenic in the Ames test with the Salmonella typhimurium. This carcinogen also exhibits a low activity in cytogenetic tests. It induces a slight increase in chromosomal aberration and in sister chromatid exchanges, but only at high concentrations [31] . 2-nitroanisole may be...
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Role of the International Labour Organization in labour law
Svobodová, Martina ; Vysokajová, Margerita (advisor) ; Štangová, Věra (referee)
60 Summary The International Labour Organisation, established 90 years ago, belongs to the main United Nations' organisations. It plays a unique role in the field of international organisations. It fights for better social and work conditions around the world. The ILO has currently 182 members, who participate in the organisation's functioning. One of its main aims is to regulate working standards. During the last nine decades, the organisation has managed to assert the principles of humanity and solidarity. It helped social and work relations in many world areas. However, when trying to answer the question: Where is this organisation heading to? Only future can answer this question. Chapter 1 deals with the general characteristics of the International Labour Organisation. Chapter 2 focuses on the relation between international and national law. It especially concentrates on how this issue is dealt with in the Constitution of the Czech Republic, i.e. introduction to ILO from the point of public law. Chapter 3 includes questions of international organisations dealing with social issues. It focuses on relations with the United Nations Organisation and the Council of Europe. Chapter 4 concentrates on the International Labour Organisation, its history, structure, organisation and function. I will focus mainly...
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Subjective pereption of Quality of life of people after spinal injury
Svobodová, Martina ; Boukalová, Hedvika (advisor) ; Štětovská, Iva (referee)
The thesis deals with the subjective perception of quality of life of persons that have suffered a spinal cord injury. The Theoretical part is devoted to the quality of life, its definitions, concepts, factors and measuring. Further, it focuses on spinal cord injuries and their consequences with regard to functionality of extremities and organs. It describes types of handicap, process and components of physical therapy. It also deals with psychological stress of a person dealing with the injury and its consequences. Focus is in particular applied to coping strategies and adaptation mechanisms. The third chapter of the Practical part is devoted to the quality of life of a specific target group, i.e. of persons that have suffered spinal cord injury. It introduces the factors and specific aspects contributing to the perception of quality of life. It also addresses some of the frequent mistakes and stereotypes in approaches to people with handicap. In the Empirical part, we have found out that people who suffered spinal cord injury perceive the lower level of quality of life in the area of health and relationships. We did not find statistically significant differences in subjective perception of quality of life depending on the level of handicap, or time that has passed since the injury. As part of...
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Measurement and Evaluation of Business Performance
Svobodová, Martina ; Heralecký, Tomáš (referee) ; Kocmanová, Alena (advisor)
This bachelor’s thesis focuses on the measurement and evaluation of the performance of Tierra Verde, Ltd. in 2015-2019. The paper is divided into 3 parts. The first part covers theoretical foundations and includes a description of financial analysis and its methods. The second part is analytical and entails a financial analysis of the company as well as an overall evaluation of the financial situation at the end. The last part introduces suggestions aiming at improvement of the current situation.
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Digital marketing strategy for Angis Plus Ltd
Svobodová, Martina
This bachelor thesis focuses on the digital marketing strategy for Angis Plus Ltd. The aim of the thesis is to evaluate the tools and strategies used by the company in the digital world, its weak point, identification of improvement and how to improve the current strategy of the company. The first part of the thesis focuses on marketing definition. Further the thesis deals with digital marketing, describes its tools, features and trends. Then defines social media. Characterizes social media, their individual communication tools, which are subsequently worked on in the empirical part. In the empirical part, the thesis deals with the description and analysis of the company and their digital tools, which the company currently uses. In the final part of the thesis there are presented advantages and disadvantages of individual tools and strategies used by the company and suggestions for improvement.
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