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Testing of potential capability of chiral ionic liquids with long alkyl chain in capillary electrophoresis chiral separations II
Müllerová, Kateřina ; Jáč, Pavel (advisor) ; Lochman, Lukáš (referee)
Department: Department of Analytical Chemistry Candidate: Kateřina Műllerová Supervisor: PharmDr. Pavel Jáč, Ph.D. Title of the diploma thesis: Testing of potential capability of chiral ionic liquids with long alkyl chain in capillary electrophoresis chiral separations II Chiral ionic liquid (−)-N-dodecyl-N-methylephedrinium bromide (DMEB) was tested as a selector for chiral separations of selected drugs such as chiral quinolones, ketoprofen, and flurbiprofen by capillary electrophoresis (CE). The effect of several parameters on enantioseparation was examined: (i) type and pH of the separation buffer, (ii) type and amount of organic modifier, and (iii) the concentration of DMEB. When using this chiral selector, only the separation of ofloxacin enantiomers was observed, while the enantiorecognition of other chiral model analytes was not successful under the conditions tested. As a next step, a CE method for the assay of levofloxacin was developed to demonstrate the potential of DMEB as a chiral selector in quality control of single-isomer drugs. The best separation was achieved with 20 mM tris buffer of pH 8.5 containing 100 mM DMEB and 20 % (v/v) of acetonitrile as the background electrolyte. The separation took place in 50 µm id fused silica capillary (80.5 cm / 72 cm) at −30 kV with UV detection...
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Self Management of Pupils of The Business Academy and The College of Turism and Language School in Karlovy Vary
Müllerová, Kateřina ; Bendl, Stanislav (advisor) ; Syřiště, Ivo (referee)
The thesis deals with student participation in the life of the school and more specifically with the work of student self-administration. The goal of the theoretical part is to define the concept of student participation and all its accessible forms. To outline the life of students self-administrations and present a current picture of the issue of student participation in the Czech Republic. To compare international experience with the work of student self-administration, as mainly in the course of the last couple of years there have been changes in thinking about student participation. The theoretical context serves as a basis for the empirical part of the paper. The main goal of the investigation is to analyze and describe the work of student self-administration at a chosen high school. The research also describes what possibilities and limits students as well as the management and teachers feel there are in relation to successful operation of student self-administration. The research was realized using a mixed qualitative/quantitative model (QUAN - QVAL scheme). The sample comprises of students, members of the student self-administration, teachers and management of a chosen high school.
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Testing of potential capability of chiral ionic liquids with long alkyl chain in capillary electrophoresis chiral separations II
Müllerová, Kateřina ; Jáč, Pavel (advisor) ; Lochman, Lukáš (referee)
Department: Department of Analytical Chemistry Candidate: Kateřina Műllerová Supervisor: PharmDr. Pavel Jáč, Ph.D. Title of the diploma thesis: Testing of potential capability of chiral ionic liquids with long alkyl chain in capillary electrophoresis chiral separations II Chiral ionic liquid (−)-N-dodecyl-N-methylephedrinium bromide (DMEB) was tested as a selector for chiral separations of selected drugs such as chiral quinolones, ketoprofen, and flurbiprofen by capillary electrophoresis (CE). The effect of several parameters on enantioseparation was examined: (i) type and pH of the separation buffer, (ii) type and amount of organic modifier, and (iii) the concentration of DMEB. When using this chiral selector, only the separation of ofloxacin enantiomers was observed, while the enantiorecognition of other chiral model analytes was not successful under the conditions tested. As a next step, a CE method for the assay of levofloxacin was developed to demonstrate the potential of DMEB as a chiral selector in quality control of single-isomer drugs. The best separation was achieved with 20 mM tris buffer of pH 8.5 containing 100 mM DMEB and 20 % (v/v) of acetonitrile as the background electrolyte. The separation took place in 50 µm id fused silica capillary (80.5 cm / 72 cm) at −30 kV with UV detection...
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Impact of a guide dog on the quality of life of its owner
Müllerová, Kateřina ; Vařeková, Jitka (advisor) ; Nováková, Pavlína (referee)
Title: The impact of a guide dogs on the quaity of its owner Goal: The purpose of this bachelor work is to find out how the guide dog ownership can affect its owner. The work is firmly focused on social participation and the activity options according to the ICF legislation, 2001. Methodology: The data collected in this research are classified as qualitative. Furthermore, the information collection was carried out by a self-created questionnaire, provided to fifteen participants. The survey was completed by 25 questions, varied by three categories (open, closed and open-ended). In the second research period of data selection, a half-structured interview was attended by two interviewees. The attendants were guide dogs owners with a visual impairment. Results: In both cases, the interviewees selected yes as an answer. They agree that a guide dog affects social participation alongside the activity options for people with a visual impairment. Guide dog positively responds on making new contacts with others, a better communication. Owners feel safe, relaxed and satisfied. Also, according to the results we received, the dog means a specific stimulation in the activity completion. Whether it is a moving activity (dog-walking) or regular daily tasks such as going to various offices, post offices and so on....
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Self Management of Pupils of The Business Academy and The College of Turism and Language School in Karlovy Vary
Müllerová, Kateřina ; Bendl, Stanislav (advisor) ; Syřiště, Ivo (referee)
The thesis deals with student participation in the life of the school and more specifically with the work of student self-administration. The goal of the theoretical part is to define the concept of student participation and all its accessible forms. To outline the life of students self-administrations and present a current picture of the issue of student participation in the Czech Republic. To compare international experience with the work of student self-administration, as mainly in the course of the last couple of years there have been changes in thinking about student participation. The theoretical context serves as a basis for the empirical part of the paper. The main goal of the investigation is to analyze and describe the work of student self-administration at a chosen high school. The research also describes what possibilities and limits students as well as the management and teachers feel there are in relation to successful operation of student self-administration. The research was realized using a mixed qualitative/quantitative model (QUAN - QVAL scheme). The sample comprises of students, members of the student self-administration, teachers and management of a chosen high school.
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Návrh strategií pro společnost působící na českém bankovním trhu
Müllerová, Kateřina
This bachelor thesis deal with Strategies suggestion for company operate in the Czech banking market. The theoretical part include banking structure, the compa-ny itself and management tools whitch is use in practical part. In the practical part is with using suitable procedures analyzed the external business surroundings. Is used SWOT analysis, PESTE analysis and alalysis of Porter's diamond. At the end of the practical part is suggestion strategy for the company that is subsequently financially evaluates. This strategy is result and purpose of my bachelor thesis.
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