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Proposal of the Motivation System in the Company
Vejnarová, Michaela ; Moravcová, Jana (referee) ; Novák, Petr (advisor)
This diploma thesis focuses on the analysis and improvement of company Zebra Technologies CZ s.r.o. First part of thesis is devoted to theoretical concepts related to this topic. In second analytical part, the company is introduced, analysis of motivation program and evaluation program of the company is carried out. Last part is focused on proposed measures to improve the company’s motivation system based on the results from analysis part of thesis.
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Immunomodulatory properties of helminth-produced molecules and their effect during autoimmune and chronic inflammatory diseases
Moravcová, Johana ; Šmídová, Barbora (advisor) ; Kolářová, Iva (referee)
Parasitic helminths produce excretion/secretion products (ESP) that affect the host's immune system to prevent damage or exclusion of the parasite. In recent decades, individual ESP molecules have been the focus of research for the treatment of autoimmune and chronic inflammatory diseases due to their immunomodulatory potential. Diseases that have been investigated in this context include ulcerative colitis, multiple sclerosis, type 1 diabetes, rheumatoid arthritis and allergic asthma. Among the pleiad of helminths and their immunomodulatory molecules, it is worth mentioning Acanthocheilonema viteae (Av17), Ancylostoma caninum (NIF), Ascaris lumbricoides (Al-CPI), Brugia malayi (BMCys), Clonorchis sinensis (CsStefin-1), Fasciola hepatica (FhHDM-1), Heligmosomoides polygyrus (HpTGM), Schistosoma japonicum (SjCystatin) and Schistosoma mansoni (Omega-1). The main effects of these molecules on the host immune system include affecting the function of dendritic cells and macrophages, influencing cytokine production and reducing the Th1 immune response, which usually leads to alleviation of disease symptoms. Based on the current state of knowledge, it is not yet certain how the molecules will work in treating patients and whether they will have the same effect when administered in the long term. Despite...
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Czech literature of the diary genre in the 1940s and 1950s
Moravcová, Jana ; Bílek, Petr (advisor) ; Wiendl, Jan (referee)
Proč tedy ještě, nestačí-li odkázat na pozoruhodnost textů samých, považuji pro sebe za nutné zabývat se deníkovou literaturou, která vznikala v době, kdy publikační možnosti byly určovány spíše politickou loajalitou a třídním původem autorů než jejich talentem a kdy se psané slovo často stávalo důvodem persekuce? Čím tyto texty, vydané mnoho let po svém vzniku, mohou oslovit současného čtenáře? Co z jejich tehdejší naléhavosti přetrvává dodnes? Vždyť společenskopolitické změny po listopadu 1989 vrátily literaturu její samoúčelnosti a kontinuitě, takže největším problémem dnešních nakladatelů jsou prodělky z dobrého vkusu, nekončící hledání způsobů, jak vydat hodnotnou knihu navzdory požadavkům trhu.
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Transition metal complexes catalyzed synthesis of biologically active estrone derivatives
Prchalová, Eva ; Kotora, Martin (advisor) ; Moravcová, Jitka (referee) ; Hlaváč, Jan (referee)
This thesis relates to the preparation and use of new non-estrogenic ligands selective for certain types of the 17β-hydroxysteroid dehydrogenase superfamily (17βHSD). Such nonestrogenic compounds, which selectively regulate the activity of 17βHSD are believed to offer new solutions in endocrine therapy, diagnosis and treatment of estrogen-dependent types of diseases. In recent years in the laboratories of my supervisor prof. Kotora differently substituted steroid derivatives with interesting biological properties were prepared. Based on the gained experiences, it was decided to prepare C-15 estrone derivatives. Such compounds are mostly unexplored, and therefore they might be a new class of interesting biologically active compounds. A method was developed for the preparation of C-15 estrone derivatives. Estrone, the starting material for the synthesis, was first converted to the appropriate intermediate, protected estra-1,3,5(10),15-tetraene-17-one. Conjugate addition of vinylmagnesium bromide to this enone yielded the starting material for further reactions, 15β-vinylestrone. Cross metathesis of 15β-vinylestrone with suitable terminal olefins provided large series of C-15 estrone derivatives with perfluoroalkylated, aliphatic and aromatic side chains. Selected unsaturated derivatives were tested...
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Synthesis of Prolinol-Based Phosphonate Nucleotide Analogues
Vaněk, Václav ; Rosenberg, Ivan (advisor) ; Černý, Miloslav (referee) ; Moravcová, Jitka (referee) ; Pour, Milan (referee)
4. Conclusion A series ofnovel isosteric 3'-nucleotide analogues (9a-e and l0a-e) was synthesized, cr-t-- and B-t--prolinol nucleoside N-methylphosphonic acids distinguished for the loss of unambiguously defined configuration at the nitrogen atom in 3'-position of prolinol nng. Remarkable conformational differences between cr-L- and B-l-prolinol nucleotides determined by NMR study suggest some similarity with the natural 5'-o-nucleotide. The same conformational changes in o-series of prolinol nucleotides fit even better the 3'- and 5'-o- nucleotides. In addition, a series of four diastereoisomeric synthons 5-8 was prepared from the commercially available lrans-4-hydroxy-l-proline, giving access to a complete set of prolinol-derived nucleotide analogues bearing cr.L-, B-t--, o.o- and p-o-conÍiguration. In order to constrain the conformational flexibility of the N-phosphonomethyl moiety, seveÍal protected compounds were subjected to N-oxidation or N-methylation which gave chiral N-oxides or quatemary ammonium salts. However, the synthesis of the respective unprotected phosphonic acids was unsuccessful, probably due to their fast decomposition. Acylation ofthe pyrrolidine ring nitrogen atom by several acylphosphonic acid derivatives led to the novel N.phosphonoformyl, /y'.phosphonoacetyl and...
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Synthesis, reactivity and biological activity of C5 substituted uracil analogues
Brulíková, Lucie ; Holý, Antonín (advisor) ; Rosenberg, Ivan (referee) ; Moravcová, Jitka (referee)
Bibliographical identification: Author's first name and surname: RNDr. Lucie Brulíková (nee Spáčilová) Title: Synthesis, reactivity and biological activity of C-5 substituted uracil analogues Type of thesis: Ph.D. thesis Department: Department of Organic Chemistry, Faculty of Science, Palacký University Olomouc Advisor: prof. RNDr. Antonín Holý, Dr.Sc., Dr.hc. mult. Advisor-consultant: doc. RNDr. Jan Hlaváč, Ph.D. The year of presentation: 2011 Abstract: The presented thesis is focused on the synthesis of various C-5 modified uracil analogues, the study of their reactivity and biological activity, especially cytotoxic activity. In the first part, the brief survey of described results for selected 5-alkoxymethyluracil analogues is performed. The second part of the presented thesis deals with the synthesis of novel uracil analogues modified at the C-5 position, the development and optimizing of procedure leading to the desired compounds, the study of biological activity and the evaluation of structure- activity relationship (SAR). This part presents the synthesis of a series of 5-[alkoxy(4- nitrophenyl)methyl)]uracil and 5-alkoxymethyluracil analogues and extended SAR studies depending on a substitution of metylene bridge directly attached at the C-5 position as well as alkoxy chain length. The last part of...
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