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Internet as an Important Factor of Globalization and its Impact on Tourism Development
Vaško, Martin ; Kubálek, Tomáš (advisor) ; Abrhám, Josef (referee) ; Čajka, Peter (referee)
The extent of the Tourism is increasingly linked to the development of information and communication technologies, especially the Internet and for a long time the online market is becoming a key aspect of its further development. Current technological development brings with it significant digitization of all processes and significantly affects how today's companies are entering and communicating on the online tourism market. Similarly, as a result of these changes, the significant change occurs in consumer behaviour, and across all age groups. With the development of these technologies, today's consumer is not only knowledgeable and more experienced, but is increasingly being constant online part of this market. The development of online tourism market is thus increasingly strongly linked with the growth of the total Internet population and currently also the one, that is using to the internet access the cellular infrastructure and equipment. The aim of disertation is to analyze the impact of the development of the internet as a global phenomenon of the last decade, and information and communication technologies on the tourism market, and to create a comprehensive look at this issue from tourism market perspective.
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Vzdělání a vzdělávání obyvatel krajů ČR s důrazem na Kraj Vysočina
Kuthanová, Veronika ; Kouřilová, Jana (advisor) ; Říhová, Gabriela (referee)
The goal of this thesis, with topic, "Education and Education of inhabitants of districts in Czech Rebublic with emphasis on district Vysočina", is to find out relation between education system and labour market in Vysočina district and whether the offer meets demand of Labour. In the first part of the thesis, basic concepts relating to education (upbringing, education, lifelong learning) are explained. Subsequently the educational system in the Czech Republic and related regulations and ducuments are described. In the second part of the thesis, the development of the educational system in the Czech Republic is analyzed and the changes in the educational structure of population of the Czech Republic are characterized. The third part of the thesis describes in more detail the development of education in the Vysočina district, and then this part follows the development of demand for labour, the development of jobs in the district and link the labour market in areas of education in Vysočina district. The thesis uses the statistical data from the (Czech Statistical Office) CSO, data from the Ministry of Education, Institute for informatik on education, regional yearbooks and information from key companies in the district Vysočina. Data is processed into tables or graphs.
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Autoimmune and lymphoproliferative diseases: associations and common mechanisms
Dobiášová, Alena ; Daňková, Pavlína (advisor) ; Hušáková, Markéta (referee)
Autoimmune and lymphoproliferative diseases share some etiologic mechanisms. The origin of the diseases is complicated process that involves an accumulation of hereditary and somatic mutations in a hematopoetic cell, which thanks to changed activity overcomes different growth and survival control checkpoints. Such mutations are for example those located in genes coding for transcription factors, apoptotic signaling molecules, costimulatory molecules and secreted exctracellular molecules. All these molecules influence the balance between survival and programmed cell death. Their dysregulated expression enables the cell to overcome defensive mechanisms of the immune system. Therefore, autoimmune and malignant cells are able to survive though, under usual circumstances, they would be selected. The main aim of this work is to shed the light on the influence of the dysregulated expression of the particular molecules on the origin of autoimmune and lymphoproliferative diseases. Key words: autoimmune ilnesess, lymphoproliferative diseases, etiology, AIRE, c-MYC, TP53, FOXP3, Fas, PTEN, Bim, CTLA-4, CD5, CD30, CD40/CD40L, BAFF, α-taxilin, IL- 10.
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B2 insertions in mouse population genetics
Kubešová, Lenka ; Macholán, Miloš (referee) ; Munclinger, Pavel (advisor)
1. Prolog Nejvíce zkoumaným savcem (s výjimkou člověka) je drobný živočich, všemi velice dobře známý a provázející člověka odnepaměti. Je to domácí myš. Narozdíl od obrovského množství poznatků o inbredních kmenech myší kupodivu doposud stále víme poměrně málo o jejich blízkých příbuzných - volně žijících domácích myších. Zvláště chybí data o genetické struktuře populací na vyšší škále (na úrovni celých kontinentů). Na této škále se v současné době pro studium populační genetiky využívá převážně mitochondriální DNA (mtDNA) díky svým unikátním vlastnostem (jednoduše izolovatelná, nerekombinující, až na vzácné vyjímky uniparetálně děděná a u obratlovců rychle se vyvíjející). Pro zjevné limitace mtDNA jako markeru (jedná se jen o maličký kus genomu navíc vypovídající jen o mateřském původu) a nejednoznačným výsledkům vyvstává potřeba nalézt pro studium populační genetiky myší vhodné markery z jiných částí genomu. Nejvhodnější možností se jeví být markery založené na SINE elementech. SINE (short interspersed elements) jsou úseky DNA, které se nacházejí v genomech obratlovců (běžně se vyskytující u savců, zejména primátů, hlodavců a kopytníků) ve vysokém počtu navzájem si podobných kopií rozmístěných na různých místech genomu. SINE elementy mají jako markery pro populační genetiku několik výhod. Jejich hlavními...
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Cytogeography of Cardamine amara in the Czech Republic and the origin of tetraploid populations
Krásná, Iva ; Koutecký, Petr (referee) ; Marhold, Karol (advisor)
Diskuse ____________________________________________________________________________________________________________________________________________________ 100 Neiova genetická diverzita byla u tetraploidních populací na okraji areálu (6245, 6249) nižší, ale jinak nebyla v míře diverzity v geografickém rozmístění populací žádná zákonitost. U triploidní populace nebyla zaznamenána žádná genetická diverzita, což opět poukazuje, že se jedná o klon. Výsledný graf PCoA analýzy od sebe oddělil skupiny diploidních a tetraploidních jedinců. Diploidní populace z kontaktních a izolovaných oblastí jsou rovnoměrně promíšené. Tetraploidi z kontaktní oblasti se objevují v prostoru blíž k diploidům, což by mohlo indikovat omezený ale existující genový tok od diploidů k tetrapoidům. Triploidní populace se nachází v prostoru kontaktních a izolovaných tetraploidních populací. Pravděpodobně díky jejich existenci dochází k sekundárnímu kontaktu a genovému toku mezi ploidními úrovněmi. Bayesova analýza odlišila jedince do čtyř shluků. Diploidní jedinci měli ve svém shluku zařazeného jednoho tetraploida. Další shluk byl tvořen oddělenou triploidní populací. Tetraploidi tvořily shluk v němž byla odděleně vyčleněná populace 6245 Kozolupy. Dendrogram (neighbour-joining tree, NJ) od sebe oddělil větev diploidů a větev, která...
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The Problem of the Quality of Life and Ageing in People with Mental Disabilities
Řehák, Radek ; Černá, Marie (referee) ; Šiška, Jan (advisor)
This diploma thesis deals with the effective prevention of problems that may arise in people with learning difficulties as they grow older. The theoretieal seetion of the thesis explores the concept of "learning difficulty", the development of care for sufferers both in the Czech Republic and throughout the world, the process of ageing as it affects the whole population, and looks at effective and appropriate strategies to address the challenges of ageing. The second seetion deseribes the range of support services available to people with learning difficulties especially the provision of "assisted" employment as a means of delivering a fulfílling life to sufferers. Such "assisted" employment is then compared with the "sheltered workshop" concept. This seetion goes on to explain the terms "institutional care" and "sheltered living" and then to explore the challenges faced by those experiencing learning difficulties when attempting to integrate into society. Brief reference is also made to the new law on sociál services and its potential to revolutionise the care of those experiencing challenges to their health. The practical seetion of the thesis deseribes the research carried out into the provision of services for adults with learning difficulties; these researches were conducted in and around Pardubice,...
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Multilinguism - learning a second foreign language
Hanušová, Alena ; Vachková, Marie (referee) ; Berglová, Eva (advisor)
The subject of this graduation thesis is "Multilinguism and Learning a Second Foreign Language". The concept of multilinguism maintains the importance of all languages, not only English, in today's multicultural world. The knowledge of mother tongue and the first foreign language can have a significant influence on learning a second foreign language. The thesis deals with the impact of these substances for teaching foreign languages. The theoretical approach to the topic of multilinguism is supported with results of a survey held at selected Czech schools.
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The use of teaching methods in nursing practice with a focus on prevention of lifestyle-related diseases.
DUBOVÁ, Marie
Diseases of affluence are those that accompany any given society at any given time. The best "treatment" for diseases of affluence is prevention, which in nursing practice can be achieved by using appropriate teaching methods. One of the diseases of affluence is tooth decay. Recent studies have shown a significant decrease in oral hygiene amongst children. The result is an increase in tooth decay which has a negative impact on the secondary dentition. Prevention should include increasing children?s awareness of their own health and learning effective teeth cleaning with the help of their parents. The role of nurses in primary prevention of oral health of children is indispensable and includes various educational activities. This thesis is focused on the use of appropriate teaching methods of tooth decay prevention in nursing practice. The aim of this study was to evaluate the impact of a prevention programme called ?A Healthy Tooth?. This programme was aimed at children in kindergarten and pupils in the first four years of primary schools. Its aim was to increase their skills and knowledge of preventing tooth decay. It was also aimed at parents of the children who were trained in this programme. To achieve the purposes of this thesis we used a methodological triangulation technique which enabled us to examine the impact of the programme by applying several different methods. The following methods were used: a questionnaire for parents and children, interviews with children and direct observation of children while they were cleaning their teeth. The questionnaire for parents and children consisted of six closed questions about the issue of tooth decay prevention. The questionnaires were anonymous and were compiled for the purposea of this thesis. The questionnaires were distributed to the children with a written consent from their parents. The research sample for the quantitative survey of parents included parents of children from kindergartens and primary schools in Jindřichův Hradec. 130 questionnaires were distributed, 128 (98 %) of completed questionnaires were returned and none of them were discarded. The research sample for the quantitative investigation of children included children from kindergartens and the first four years of primary schools in Jindřichův Hradec. With the consent of the parents, 24 children from kindergartens and 108 children from primary schools were interviewed. 132 (100%) questionnaires were classified for further evaluation. The data were evaluated using Microsoft Excel charts. To verify the hypotheses, we used a test of independence ? chi-square ? using a PivotTable. For the semi-structured interviews with children, we created a schedule of questions. The central topic of the interview was tooth decay and its prevention. Interviews with children were conducted with the written consent of their parents and were anonymised. Direct observation of children during toothbrushing was conducted to explore the method and sequence of cleaning their teeth. It was noted in the answer sheet and photographs were taken with the consent of the parents of the respondents. The research sample for the qualitative survey consisted of ten children ? five children from kindergartens in Jindřichův Hradec and five children from primary schools in Jindřichův Hradec. The data were processed in the SmartArt diagrams and tables using Microsoft Office Word 2007. The results of the survey helped determine the depth of knowledge and skills in the tooth decay prevention of children. It showed some positive effects of the use of appropriate teaching methods in the effectiveness of the prevention programme in nursing practice. It also contributed to the improvement of dental health in the child population.
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Wisconsion card sorting test. Screening of performance in Czech population
Kawaciuková, Radka ; Šípek, Jiří (referee) ; Niederlová, Markéta (referee)
Wisconsin Card Sorting Test (WCST) has been published as a measure of flexibility of thinking. Soon, it became a popular neuropsychological tool sensitive to brain damage, especially frontallobes. Arising from the knowledge of relationship between frontal lobes and executive functions, WCST is also called an executive task. Various versions of the test have been developed. Heaton' s standardization is in the focus of this thesis because it is the most often used version. Wisconsin Card Sorting Test is supposed to be the most common executive measure in neuropsychological research. The test output gives us 16 various scores, which reflect different cognitive processes. Each score has been provided with normative data on American population. However, clinically the most valid scores are scores of perseveration: perseverative responses and perseverative errors. There is certain evidence of impaired performance in patients with frontal lobe damage, especially left-side. Additionally, assumptions arising from physiological studies on healthy people or patients with various types of neurological illnesses suggest WCST to be sensitive not only to impairment of prefrontal cortex but also to the impairment of prefrontalsubcortical circ.uit including thalamus and basal ganglia or the prefrnntalsu bt:orli ca 1 t:l...
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Morfogeneze orálního skeletu mihule ve vztahu k evoluci čelistí
Romášek, Marek ; Černý, Robert (advisor) ; Jandzík, Dávid (referee)
4 Neural crest-derived cellular cartilage is one of the defining characteristics of vertebrates. Elaboration of this tissue and its patterning allowed the evolution of jaws in the gnathostome lineage. Together these hallmarks helped jawed vertebrates become one of the dominant taxons in the animal kingdom. Lampreys, as basal jawless vertebrates, lie at a unique phylogenetic position that makes them ideal organisms for the study of evolution of vertebrate/gnathostome novelties. Larval lampreys possess a special oral skeleton composed of a tissue related to cartilage, termed mucocartilage. Despite considerable attention that has been paid to the evolutionary significance of mucocartilage, it is not yet clear, how this unique feature arises in development and to what extent it is homologous to gnathostome jaws. In this study, the development of oro-pharyngeal region was analyzed in the sea lamprey Petromyzon marinus. SEM imaging revealed shaping and topographic relationships of embryonic tissues, detailed plastic histology coupled with expression analyses of several molecular markers were used to describe origin, histogenesis and morphogenesis of mucocartilage. Furthermore, genetic regulation of the tissue was investigated in order to identify its unique or shared features. Mucocartilage is seen to...
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