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Study of mechanical properties and dynamics of biomembranes and single molecules with the use of laser beam - an overview
Jonáš, Alexandr ; Zemánek, Pavel
A micron-sized dielectric particle confined in a laser trap can be employed as a probe for the measurement of forces in the range from piconewtons to hundreds of piconewtons. Thus, if a biological system of interest (e.g. DNA molecule, single myosin or kinesin molecule, cell membrane) is attached to such a probe, its mechanical and dynamical properties (elasticity, viscosty, forces associated with movement) can be studied during its interaction with the environment with unprecedented resolution. This article introduces the basic principles of the laser trapping and force measurement and illustrates on several examples the great potential of the light-based force transducer for exploiting non-invasively the dynamics of basic biological systems.
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Effective dashboard design in the analytical tasks of IS
Janeczková, Agata ; Šedivá, Zuzana (advisor) ; Pour, Jan (referee)
The thesis deals with analysing and designing an effective dashboard. By way of introduction the topics of Business Intelligence, data storages and data quality are described. Then, an overview of analytical outputs is given and the process of their formation is outlined. The basic principles of an effective design of management reports are described, with emphasis laid on the end user. The thesis focuses on important factors of efficiency, such as applicability of transferred information and the form of their transfer. The practical part concentrates on the improvement of the efficiency of a particular dashboard. Besides the rules of a correct design, knowledge of cognitive psychology is also used for this purpose. Upon an analysis of deficiencies of an existing dashboard, proposed changes are incorporated. Changes resulting in more effective transfer of information via a dashboard are based on a theoretical basis of the previous section.
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Clustering and regression analysis of micro panel data
Sobíšek, Lukáš ; Pecáková, Iva (advisor) ; Komárek, Arnošt (referee) ; Brabec, Marek (referee)
The main purpose of panel studies is to analyze changes in values of studied variables over time. In micro panel research, a large number of elements are periodically observed within the relatively short time period of just a few years. Moreover, the number of repeated measurements is small. This dissertation deals with contemporary approaches to the regression and the clustering analysis of micro panel data. One of the approaches to the micro panel analysis is to use multivariate statistical models originally designed for crosssectional data and modify them in order to take into account the within-subject correlation. The thesis summarizes available tools for the regression analysis of micro panel data. The known and currently used linear mixed effects models for a normally distributed dependent variable are recapitulated. Besides that, new approaches for analysis of a response variable with other than normal distribution are presented. These approaches include the generalized marginal linear model, the generalized linear mixed effects model and the Bayesian modelling approach. In addition to describing the aforementioned models, the paper also includes a brief overview of their implementation in the R software. The difficulty with the regression models adjusted for micro panel data is the ambiguity of their parameters estimation. This thesis proposes a way to improve the estimations through the cluster analysis. For this reason, the thesis also contains a description of methods of the cluster analysis of micro panel data. Because supply of the methods is limited, the main goal of this paper is to devise its own two-step approach for clustering micro panel data. In the first step, the panel data are transformed into a static form using a set of proposed characteristics of dynamics. These characteristics represent different features of time course of the observed variables. In the second step, the elements are clustered by conventional spatial clustering techniques (agglomerative clustering and the C-means partitioning). The clustering is based on a dissimilarity matrix of the values of clustering variables calculated in the first step. Another goal of this paper is to find out whether the suggested procedure leads to an improvement in quality of the regression models for this type of data. By means of a simulation study, the procedure drafted herein is compared to the procedure applied in the kml package of the R software, as well as to the clustering characteristics proposed by Urso (2004). The simulation study demonstrated better results of the proposed combination of clustering variables as compared to the other combinations currently used. A corresponding script written in the R-language represents another benefit of this paper. It is available on the attached CD and it can be used for analyses of readers own micro panel data.
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Global Economy Outlook - October 2016
Česká národní banka
The October issue of Global Economic Outlook presents the regular monthly overview of recent and expected developments in selected territories, focusing on key economic variables: inflation, GDP growth, leading indicators, interest rates, exchange rates and commodity prices. In this issue, we focus in detail on the industrial producer price index (PPI), which, alongside the consumer price index (CPI), is a key indicator of inflation on the production side of the economy. We also explain the specifics of the PPI, especially in the EU, and present a model simulation indicating the sensitivity of the PPI to a change in oil prices.
Fulltext:  PDF; PDF
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Design of Experiment for Non-Stationary Processes of Production
Jadrná, Monika ; Macák, Tomáš (advisor)
The doctoral thesis is concerned with the services sector and the area of mass production. Particularly, the optimization of the product portfolio of the travel agency and the optimization of production rounds of ammunition.
The theoretical part deals with the current overview of discussed topic. Further, the terminology and methods of the decision-making process are defined to support decision making. The theoretical basis of research focused on the choice of appropriate input variables in the area of services, and on the choice of a particular material option in the production area and appropriate equipment for the production. The theoretical part forms the basis for the practical part of the thesis.
For the doctoral thesis was chosen an enterprise operating in the defined sector. Product portfolio for the services sector is optimised using Fuzzy logic and Fuzzy sets so that the enterprise can maintain its competitiveness in todays highly ambitious market. Product portfolio for manufacture is optimised for achieving desired properties of the product.
The main aim of the thesis is to propose a new methodological approach for the management of selected business processes in their nonstationary time course. The aim of the practical implementation is to verify the functionality of the proposed methodological approach, both in the area of services and in the field of mass production.
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One-Sided Random Context Grammars
Zemek, Petr ; Černá, Ivana (referee) ; Doc. In.g Petr Sosík, Dr. (referee) ; Meduna, Alexandr (advisor)
Tato disertační práce zavádí jednostranné gramatiky s nahodilým kontextem jako řízené gramatiky založené na bezkontextových gramatikách. V těchto gramatikách je ke každému pravidlu přiřazena množina povolujících symbolů a množina zakazujících symbolů a množina pravidel je rozdělena na množinu levých pravidel s nahodilým kontextem a množinu pravých pravidel s nahodilým kontextem . Levým pravidlem s nahodilým kontextem lze přepsat neterminál pokud se všechny povolující symboly vyskytují vlevo od přepisovaného neterminálu a žádný zakazující symbol tam přítomen není. Pravé pravidlo s nahodilým kontextem lze aplikovat analogicky, ale ona kontrola na přítomnost a nepřítomnost symbolů je provedena doprava od přepisovaného neterminálu. Práce je rozdělena na tři části. První část uvádí motivaci za zavedením jednostranných gramatik s nahodilým kontextem a umisťuje materiál pokrytý v této práci do vědeckého kontextu. Poté dává přehled základů teorie formálních jazyků a některých méně známých oblastí, jejichž znalost je nutná pro pochopení studovaného tématu. Druhá část tvoří jádro práce. Formálně definuje jednostranné gramatiky s nahodilým kontextem a studuje je z mnoha pohledů. Mezi studovaná témata patří generativní síla, vztah k jiným typům gramatik, redukce, normální formy, nejlevější derivace, zobecněné a LL verze těchto gramatiky. Třetí část této práce zakončuje diskusi několika poznámkami. Mezi ně patří poznámky týkající se aplikovatelnosti zavedených gramatik v praxi, bibliografie a otevřených problémů.
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Biotechnology in the world and the Czech lands
Pěknicová, Jana
Biotechnology in the world and the Czech lands Biotechnology is any technology that uses biological systems, living organisms, or parts of a particular production or their conversion or other specific applications. The lecture should show a brief overview of the biotechnology industry in the world, in the Czech lands, in the Institute of Biotechnology CAS, v. v. i., and in the project BIOCEV: 1. Biotechnology in the world • Beginning of biotechnologies • Milestones • Application in medicine • Gene therapy • Genetic modification (science, agriculture, industry) 2. Biotechnology in the Czech lands • Czech biotechnology: milestones 3. Institute of Biotechnology CAS, v. v. i. • Research and outputs into practice 4. BIOCEV – Biotechnological and Biomedicine Centre of the Academy of Sciences and Charles University in Vestec Establishment of centre of excellence as part of the European scientific area guaranteeing the development of modern biotechnology and medicine.
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Role and competences of the nurse in compared with Czech Republic and Namibia
KLYNCYPAROVÁ, Hana
Theoretical grounds The nursing profession among the professions and mission. Job nurse is one of very important professions. Nurse is an independent worker who has an irreplaceable role in the provision of care. In practice, certain roles, such as the role of a caregiver, the educationalist, communicator, the role of the lawyer, consultant, person, who brings the change, manager and researcher. These roles are constantly interacting and are interconnected. Health care has multidisciplinary and multiprofessional character. Although each of these professions contribute to care in a unique way, all share certain skills that are necessary to ensure the quality of care. Over the years there have been increasing professional skills and increase competencies. Expanded the range of services for which they previously did not have the competence or sisters had a written authorization of a doctor. This work is made up of theoretical and empirical part. The theoretical part provides an overview and information on the field of nursing and its history, dealing with the care system and education system in the Czech Republic and Namibia. The following list of findings roles and their importance in the nursing profession. The last part deals with the competencies of nurses in both countries. The aim of the thesis: The aim of the study was to determine the roles and responsibilities of nurses in the Czech Republic and Namibia. To to obtain this information were chosen research question what role nurses advocate in the Czech Republic and Namibia, and what are nurses in the Czech Republic and Namibia competence. Methods: To ensure the necessary data and information was chosen qualitative research through deep interviews. Nurses who were interviewed were from a hospital in the Czech Republic and nurses from hospitals in Namibia Keetmanshoop. All interviews were recorded on a Dictaphone andwritten down on the paper. Results: Recorded interviews were analyzed after writing down, we were using paper and pencil methods. Dialogs were openly coded. The analysis of these data arose following categories: the role of caregivers, the role of the teacher, communicator, the lawyer's role, the role of counselor, role of person who brings the change, the role of leader, manager's role, the role of researcher and categories of competence. Individual categories were assigned to subcategories. All informationwere are illustrated by clear diagrams of the individual categories. Conclusion: The Research shows that nurses have a general maintenance of the roles and competencies, actually both of sides, Namibia and Czech Republic also. both groups were mostly able to define roles in nursing care. Surprisingly czech nurses most failed in the role of the Advocate, while African colleague have proven to be very informed. Research also showed negative effect of paperwork and administration in czech system. Nurses having feeling they do not provide active care as they would be able to. Czech nurses seems also low initiative and ambitious, Czech nurses do not desire for increasing competence on the other hand African nurses, who have more competencies, want still more, than they already have.
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A nursing issue: peripheral venous catheter
TOMÁNKOVÁ NOVÁKOVÁ, Monika
Peripheral venous catheter is used to access the venous system. It is one of the most commonly used invasive procedures in health care facilities. This procedure falls within the competence and daily tasks of nurses. Therefore this type of nursing care is susceptible to risk of proceeding routinely which might result in conscious or unconscious errors. Peripheral venous catheter needs to be introduced into the patient's vein in the following cases: planned parenteral nutrition, infusion or transfusion therapy, application of intravascular medication or contrast media, rehydration, blood sampling (which can be performed immediately after introducing the peripheral venous catheter and before administrating medication) and also during an emergency care for critically ill (such as cardiopulmonary resuscitation). Nurses should be as knowledgeable as possible about this issue so that the peripheral venous catheter can be introduced well and fulfil its purpose. It is important to ensure that nurses obtain all the necessary information about their patients before inserting the catheter and that they are able to properly inform the patients about the procedure and to communicate with them. Next, nurses should be familiar with the correct procedure for inserting catheters, they should be informed about possible contraindications and know how to choose the correct type of catheter as well as where to place it. Furthermore, nurses should care for this vascular access correctly and provide the patient with enough information about taking care of the catheter after the procedure. Finally, nurses should be aware of their own potential errors and also of possible complications. Therefore they should employ aseptic technique so that they can eliminate nosocomial infections. The thesis is divided into a theoretical and an empirical part. The theoretical part focuses on the history of peripheral venous catheters and their types, indications and contraindications, necessary equipment, nursing care, complications, etc. The empirical part consists of a research. The aim of the thesis was to map the use of peripheral venous catheters in hospitals as well as to identify factors that may lead to problems among the patients with peripheral venous catheters. Four research questions were assigned to these aims. 1. What is the procedure prior to inserting a peripheral venous catheter? 2. What are the standards of caring for patients with an inserted peripheral venous catheter? 3. In which steps of caring for peripheral venous catheters do the nurses lack knowledge? What equipment do the nurses prepare in order to insert a peripheral venous catheter? The Bachelor's thesis was conducted using a qualitative research survey. The methods of collecting data included semi-structured interviews and participant observations. The research was carried out only in one hospital ward and it was anonymous. First, the data were collected by means of a semi-structured interview. The nurses were asked 14 questions (see Appendix 8). During this interview, several more subquestions were added. The results of the interviews were then grouped into several categories for the sake of clarity. The second method of collecting data was participant observation. The observed facts were recorded into an observation sheet (see Appendix 9). The same nurses who were interviewed were also observed. This Bachelor's thesis has been written in order to provide a basic overview of the peripheral venous catheters. It could be used as an information source for more experienced as well as novice nurses. The practical output of this Bachelor's thesis is a nursing care standard concerning peripheral venous catheters. This standard was missing in the hospital ward and could help the nurses to take care of these vascular accesses, to proceed correctly and eliminate possible errors (see Appendix10).
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Development of the structure of breeds of hunting dogs in the administrtive territory of the town the Nymburk
Suchánková, Růžena ; Hanzal, Vladimír (advisor)
Processing overview of the structure of hunting dogs and their frequency in the administrative territory of the town of Nymburk and trying to determine whether the relationship of the structure of hunted animals.
Method of comparing statistical compilations drawn from the administrative area of the town of Nymburk.
Canine statistic-the number of bred dogs entered in the stud book, the number of dogs registered for the spring downspouts, the number of dogs who have passed the trial, the number of breeding dogs.
The ratio of small and large breeds of dogs at a time.
Fads breeding hunting dogs in a given time period.
Statistics breeding and hunting on the territory in the same period. Statistics restocking in the locality.
Results after treatment compared to each other and to confirm the relationship to the structure of hunted animals.
Finally, the recommendations for practice in a given area.
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