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Retargeting of viral particles for directed cargo delivery into cells
Váňová, Jana ; Španielová, Hana (advisor) ; Kuthan, Martin (referee)
Due to their structure and ability to enter cells where they release their content, viral particles represent an attractive tool to deliver cargo to a cell. For therapeutic usage of viruses it is necessary to ensure the specific and highly efficient entry to target cells. This thesis offers an overview of methods used for virus retargeting with the intention to evaluate the success of retargeting in terms of specificity and efficiency of designed viral particles when entering a cell. On the basis of published data and considering the mechanisms of viral infection, the thesis demonstrates the difficulty to prevent the nonspecific viral particles from entering the cell and concludes that reaching total specificity is apparently impossible. Despite these small limitations, viral nanoparticles are a revolutionary therapeutic tool for delivering cargo to the cell and it is necessary to exploit their potential.
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The organization of primary and lower secondary education in Europe: Comparative analysis of the Czech Republic and Finland in terms of equity.
Paulová, Kristýna ; Kalous, Jaroslav (advisor) ; Mouralová, Magdalena (referee)
This thesis is a comparative study, which compare two selected countries, Finland and the Czech Republic in the organization of basic education. The benchmark of equity has been chosen as a comparative criterion. This criterion was further divided into single indicators. The key indicator in this respect was the selectivity of educational systems. For this reason, the thesis presents especially the form and the extent of differentiation of students by each level of basic education in both chosen counties and try to find the number of children who are educated in them. The results of comparative analysis showed that five educational programs with different degree of quality exist in the Czech Republic, while there are only two types of schools in Finland. Finland has used the differentiation of pupils in schools, even in clases in much smaller scale in comparison with the Czech Republic. In Finland, there are no classes with extended teaching of some subjects. The next difference between selected countries is about the age when the students start to be selectived. The students are not differentionated before 16-years in Finland. On the other hand, students of the Czech Republic are divaded in various educational programs after completion of primary school, that means in 11-years. Only 4 % of...
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Application of analytical methods in study of heterogeneous catalytical processes
Pavlatová, Jana ; Vohlídal, Jiří (advisor) ; Svoboda, Jan (referee)
Acylation of cyclohexene can provide number of reaction products. Cyclohexene, 1-methylcyclohexene and 3-methylcyclohexene were acylated with propionic anhydride over diferent zeolite structures and molecular sieves. Cyclohexene acylation led to propionylcyclohexene. The major acylation products of 1-methylcyclohexene is 2-methyl-3-propionylcyclohexene. Reaction product of 3-methylcyclohexene acylation is 4-methyl-3-propionylcyklohexene and 3-methyl-2-propionylcyclohexene. The aim of acylation biphenyl with carboxylic acid anhydrides and chlorides was to prove reaction with the highest conversion of substrate. The highest biphenyl conversion was obtained with octanoyl chloride and hexanoic anhydride over zeolite USY (15). The highest selectivity to 4-acylbiphenyl was observed.
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Laboratory device involving the high selectivity filters
Tuhý, Luboš ; Kovář, Jan (referee) ; Petržela, Jiří (advisor)
This project deals with the frequency filters of high selectivity. The area frequency filtering is fairly comprehensive and theoretically demanding discipline. The aim of this work isn’t to describe in detail and to include knowledge of the frequency filters, but only to clarify the aforementioned issues. In particular, we focus practically on filters working on other physical principles, especially on the crystal structure of partition filters and ceramic filters. The circuit simulation programs through classes Spice will be one of the parts of the theoretical analysis. There will be presented various options for implementing these filters, and the test products used in the design. The laboratory exercises dealing with frequency filtering and measuring engineered product will be made and based on the theoretical findings of this work. The laboratory exercises will include the developing of the model protocol.
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A Low Voltage Wiring System for an Office Block
Nestrojil, Martin ; Slavata, Petr (referee) ; Kadlec, Radim (advisor)
This paper describes the design of a low voltage network in an office building. In the beginning work is given for the theoretical part of the topics that we need to create a network design in a given building. In this part of the guiding principles are conductor sizing, fuse wires and a selection of protective devices. Everything was sought in scientific publications and Articles. The theoretical part will be followed by a practical part with the first adjusted underlying schema, and then will address a practical design using programs supplied by the company Eaton. The goal of this work is to get acquainted theoretically with the main principles of network design, and then practically with your programs and create a complete network design of the building.
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Line protection against overload and short circuit
Konšel, Ladislav ; Vaněk, Jaromír (referee) ; Valenta, Jiří (advisor)
This work includes a theoretical treatise on the operation of electrical wiring for the overload and short circuit. This is mainly on thermal effects of over current and their influence on the properties of conductors and insulation. Work Includes links to determine the load current, depending on the properties of leadership and its surroundings. It also deals with the protection of conductors against overload and short circuit. The work includes measurements process of warming wires. Practical project of proposal circuit is created using SICHR. The project includes proposals of conductor’s sizes and safety components for both residential building and individual flats.
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MW Converter for SW Receiver
Lejsková, Alena ; Lukeš, Zbyněk (referee) ; Šebesta, Jiří (advisor)
This thesis concerns about the network synthesis of receivers with the demand for conversion of the input signal and a following implementation of assigned converter. At first it introduces the readers with the basic division of radio waves and with parts, which are important for a high-quality receiver, then it deals with general properties of input networks of receivers, division of parts and kinds of connection, that are used in the communications. The concept of connection is intended to nonspecialists too, that is why it describes step by step each of parts of the network, including the calculation or possible solution and the choice of convenient parts. The aim is also to present the frequency conversion as an important part of signal receiving that we want to use in communication systems.
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MV Overhead Line Protections and their Coordination with Autoreclosers
Šoustal, Petr ; Skala, Petr (referee) ; Orságová, Jaroslava (advisor)
The aim of this Master’s Thesis is to describe protections for overhead lines in distribution networks. Here are described requirements for the protection and the basic protections. Protections are divided according to their protective function. For each protection is given its use and its power plans. It is stated in the work setting of protection in the real network. On this network is simulated place with short-circuit and described the action of protection. The work also deals with the coordination of protection with automatic circuit breakers. This chapter shows that, given the selectivity is not possible to deploy two or more reclosers (remotely-operated switches) to the core network management. The next chapter describes two representatives reclosers available on the Czech market OSM 27 and GVR 27. Chapter describes and compares their performance characteristics. Conclusion the work includes a proposal protected the lead in incorporating automatic circuit breakers (remotely operated circuit breakers and reclosers). The proposal is based on two different levels of annual number of interruptions and duration of annual general interruption of electricity supply. For these levels the company EGÚ Brno, a.s. proposed several variants of the use of remote-controlled in terms of reducing the cost of the penalty. Our task was to choose a variant that would be applicable in the real network. Reducing costs is feasible only in the limits Ln = 6 failures / year and Lt = 720 min / year, where the selected option No. 4. The limits Ln = 8 failures / year and Lt = 1,080 min / year, not in the real network may no option in terms of selectivity.
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