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Innovation in the provision of on-board service and related products of a selected railway operator
BLAŽKOVÁ, Natálie
The bachelor thesis focuses on the definition of transport services and on-board service of RegioJet, a. s., which focuses mainly on the provision of transport and shipping services in the passenger rail and road transport sector. The aim of the bachelor thesis is to analyse the current status, trends and customer preferences in the provision of on-board service and related products at a selected railway carrier. The thesis starts with the theoretical part, first the key concepts of the passenger rail transport are specified. The next chapter is devoted to methodology. Here the main objectives of the thesis are presented and the research questions are formulated. Furthermore, the methods used in data collection are mentioned, which include a questionnaire survey, a semi-structured interview and the actual observation. The last chapter introduces RegioJet, a. s. itself, its corporate activities and services provided. Then, the results of the research methods are summarized and suggestions for innovations and development opportunities for the company under study are prepared.
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Design and production of experimental axle part
Volfík, Jiří ; Slaný, Martin (referee) ; Zemčík, Oskar (advisor)
The content of this diploma thesis is a design of construction and selection of suitable material for upper-carrier part used for racing vehicle, produced by FDM 3D printing with the alternative option to replace an existing part, which was produced by conventional technique of CNC machining. Various versions of the experimental part are analyzed by FEM and compared in terms of safety coefficient with target to select the most appropriate construction design. The chosen version of the model is at the end compared with already existing part, which was also analyzed by FEM.
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The Proposal for Optimization of Logistic and Warehousing
Valenta, Martin ; Poláček, Tomáš (referee) ; Luňáček, Jiří (advisor)
The Bachelor thesis „The proposal for optimalization of logistics and warehousing“ aims to optimize supply and transportation process, while using ABC analysis and procurement of a new vehicle. The main objective of this thesis is to improve the process from a financial and time efficiency perspective. First chapter contains theoretical knowledge of logistics, transport and warehouse management, that will be used to analyze the current situation and subsequently propose improvements to the waknesses of these processes.
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Biofilm formation in probiotic cultures and its application in pharmacy
Ryšávka, Petr ; Obruča, Stanislav (referee) ; Vorlová, Lenka (referee) ; Márová, Ivana (advisor)
The work was comprehensively focused on the development of adhesive forms of probiotics in the form of a biofilm on combined carriers with a prebiotic component. The second part dealed with the influence of food on the multiplication and survival of selected types of probiotic bacteria. Subsequently, the effect of individualized probiotic supplements on changes in the human intestinal microbiome was monitored. Suitable adherent probiotic strains for biofilm formation were selected and tested. Methods have been introduced and different variants of carriers for culturing and binding bacteria have been tested. In vitro experiments verified the stability of biofilm stucture and its resistance to low pH, bile and antibiotics in comparison with the planktonic cell form. The antimicrobial effect of probiotic strains in the form of a biofilm was studied. The cultivation of the multispecies biofilm on the combined carrier was optimized and the stability of the biofilm and the final viability of probiotic bacteria were confirmed. Furthermore, the influence of various foods and beverages on the viability of probiotic bacteria was evaluated with emphasis on the simulation of passage through the gastrointestinal tract. Both models, solutions with standardised concentrations of alcohol, sugar, salts, proteins or different pH and different types of real foods and beverages were tested. The effect of food and beverages was tested on monocultures of Lactobacillus acidophilus, Bifidobacterium breve and on probiotic capsules containing a mixed culture of probiotic microorganisms. The survival of probiotics in various food matrices in the simulated gastrointestinal tract was quantitatively different. We managed to define foods suitable for supporting the multiplication of probiotic bacteria. A separate part of the work was focused on the targeted modulation of the intestinal microbiome by individualized probiotics that were prepared on the basis of molecular biological analyzes of the intestinal microbiome aimed at detecting the percentage of lactobacilli, bifidobacteria and phylum Firmicutes and Bacteroidetes. Personalized probiotic supplementation confirmed the positive effect of this approach on microbiome changes, especially on the increase of the content of lactobacilli, bifidobacteria and the overall diversity of the microbiome.
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Static analysis of detail of metal connection
Efenberk, Tomáš ; Nevařil, Aleš (referee) ; Vlk, Zbyněk (advisor)
The subject of this bachelor’s thesis is structural analysis of detail of metal connection. This is a connection of the celiling and the beam. The program by Dlubal Software s. r. o. was used to create the model. The model was developed on the basis of a semester project “Multi-storey building of mass garages” from the source of the subject BO008 – Metal Structures 2. The model was developed in accordance with valid EN ISO standards. The main purpose of the bachelor thesis is to analyse the classical steel connection and to simulate as closely as possible the conditions of the load, which are connected to the metal connection.
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Analysis of the Order Processing in the Company TNT EXPRESS CZ
Šťastný, Jan ; Kopfová,, Alena (referee) ; Juřica, Pavel (advisor)
This thesis analyzes the order processing in the company TNT Express CZ. The theoretical part contains the basic concepts associated with the doctrine of logistics. In the analytical part, a second part, familiar with the company and its market activities. Last practical part deals with current order processing in the company and the benefits and shortcomings of the deployment sites for the new, larger premises in Brno export and import distribution center.
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Construction of comparison measuregauge for measurement of tools.
Brabenec, Petr ; Dočkal, Aleš (referee) ; Ždímal, Pavel (advisor)
This work is about construction of a comparison gauge to meausure revolving tools. The gauge measures cutting and clamping parts of standard and special reamers. The gauge is unique and is designed for a company manufacturing concerete. It was designed in accordance with requirements and a prototype was tested for functionality. There is made analysis, development, design, theoretic estimation and practical verification of accurancy.
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Chain Conveyor
Štěpán, Marek ; Dlesk, Daniel (referee) ; Škopán, Miroslav (advisor)
The aim of this diploma thesis is to design the control picking unit for the storage system Multitower. This work deals with the storage of rods, safety requirements and design of structures. The design part solves the actuator design, choice of chain tensioning system and torque transmission. The strength analysis of important components is solved in last part.
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Formation of biofilm by probiotic bacteria and its processing to solid drug form.
Grossová, Marie ; Rittich, Bohuslav (referee) ; Buňka, František (referee) ; Márová, Ivana (advisor)
The aim of present work is cultivation of probiotic bacteria L. acidophilus, B. breve and B. longum in such a way that the culture forms cells clusters or comprehensive biofilm on the variety of free carriers. Biofilm formation of L. acidophilus on the silica from point of view bile and acid tolerance in gastrointestinal tract was studied. While the number of living cells in planktonic form (planktonic form) at pH 1 fell by 30 %, the viability of the biofilm cells was maintained to 90 % under the same environmental conditions. The biofilm culture showed also the protection against environment contained bile. Furthermore, the possibilities of drying procedures of biofilm cultures used as commercial technologies in pharmaceutical industry were studied. The comparison of freeze-drying and fluidization bed drying showed, that freeze-drying is more suitable method, which is able to achieve higher amount of viable cells after drying than fluidization bed drying. The effectivity of freeze-drying method is dependent on the selection of suitable cryprotective medium. In this case, about 90 % higher viability after freeze drying was achieved in comparison with fluidization bed drying. Finally, the industrial processing of probiotic strains into the solid dosage form was studied. Tablets should be produced at hardness between 70 and 90 N and water activity of tablet mixture can be maintained below 0.3. Consequently, the drying step of the tablets in a hermetically closed space with at least 10 % of silica gel must be ensured. Thereafter, the tablets contain (5.4 ± 0.7)109 viable cells after 6 months of drying process. Capsule production technology has no significant effect on the cell‘s viability during production. The triplex blistering foil for primary blistering of probiotic capsules was chosen. The triplex foil, which has low values of water vapour transition rate (0.07 g H2O / (m2 × day) and oxygen transition rate (0.01 cm3/m2 × day), was chosen. Other studied blistering foils commonly used in the pharmaceutical industry are not suitable for long storage of solid dosage forms contained probiotics.
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