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Benchmark of the Computational Tools for the Prediction of the Effect of Mutations on Protein Stability
Berezný, Matej ; Martínek, Tomáš (referee) ; Musil, Miloš (advisor)
Návrh proteínov vyžaduje informáciu o tom ako mutácie ovplyvňujú celkovú stabilitu proteinu. Pre tento prípad existuje mnoho verejne dostupných nástrojov avšak ich kolektívne používanie či porovnávanie je veľmi pracné. Presne pre tento prípad som vyvinul BenchStab; konzolovú aplikáciu/Python knižnicu navrhnutú pre rýchlu a priamočiaru manipuláciu s 18 prediktormi, umožňujúc hromadné získavanie mutačných výsledkov. Zároveň som vytvoril novú unikátnu dátovú sadu, získanú z FireProtDB. Tento dataset som použil na porovnanie 24 rôznych predikčných metód pomocou rôznych metrík.
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Design of the timber trailer
Jílek, Jan ; Pokorný, Přemysl (referee) ; Mergl, Václav (advisor)
The bachelor thesis deals with the design of the structure of a forwarding trailer and analytical stress calculations at specific joints. The first part of the thesis focuses on describing the components, researching similar trailer structures, and summarizing legislative requirements. Furthermore, the structure of the designed trailer is described, and analytical calculations are performed. The thesis also includes drawing documentation of the assembly and subassembly of the welded frame.
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Analysis and design of the use of the existing building in the village of Stařeč
Janovská, Dagmar ; Hlavinková, Vítězslava (referee) ; Čech, Josef (advisor)
This diploma thesis introduces an analysis and a suggestion for a new usage of a structure, which is located in Stařeč, through the method of highest and best usage, otherwise known as HABU. The first part focuses on explaining terms used in the thesis. Afterwards, methods and their reasonings are explained. The next part introduces suggestions for a new usage of the structure, which are examined by HABU methods, inappropriate suggestions are eliminated. The chosen suggestion reaches the best and highest usage for Stařeč.
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Zlín FCK Technology
Kučera, Petr ; Pecka, Lukáš (referee) ; Štěpán, Marek (advisor)
The diploma work deals with the design of a residential building in the town of Malenovice u Zlína, where a new residential complex is to be built on the site of the former Malenovice sawmill. The land is located in close proximity to the main road to Zlín. The work proposes a modular house system made of prefabricated CLT elements with social and community overlap. A system that allows rapid construction and creation of buildings with different configurations according to the given requirements not only in the territory of Malenovice. The design system includes small-scale flats with elements of variable furniture, which allows to reduce the cost of housing, which is responding to the current unaffordable housing, but maintaining human comfort. The design also addresses the efficient use of technology on site and its sometimes excessive use.
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The influence of the Classical antiquity on the Romanesque period in Bohemia and Moravia
Jubánek, Tomáš ; Royt, Jan (advisor) ; Kuthan, Jiří (referee)
My bachelor's thesis tries to describe and document the mediated influence of the Classical antiquity on constructions in the Romanesque period in Bohemia and Moravia. It takes into account the historical development from the beginning and extinction of the antiquity era until the end of the Romanesque period, contextually elaborates on the development of architecture in Western and Central Europe and on significant buildings - the model examples it illustrates the ways of influence of antiquity leading to the territory of Bohemia and Moravia with special regard to Christianity and its role in the formation of architecture, as well as the witness of ancient architecture, Marcus Vitruvius Pollio. It documents, on few suitable examples, the influence of the antiquity on the architecture of specific buildings in Bohemia and Moravia, namely the Convent of the Premonstratensian Sisters in Doksany, palace in the Olomouc castle, the Church of St. Procopius in Záboří nad Labem, the Church of St. James the Older in Jakub near Kutná hora and finally the Church of Sts. Peter and Paul in Řeznovice in Moravia. The results of the examination are then evaluated at the end of the bachelor's thesis.
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Structural studies of an abasic site DNA damage repair and DNA interstrand cross-link formation
Landová, Barbora
DNA damage refers to any alteration or modification in the DNA structure that deviates from its natural state. Abasic site (Ap site) is one of the most common DNA lesions resulting from spontaneous depurination/depyrimidination or enzymatic base excision. When left unrepaired it can lead to a cascade of genetic mutations, potentially causing diseases like cancer. Understanding DNA repair mechanisms is vital for medical research and applications. Bacterial MutM is a DNA repair glycosylase, removing DNA damage generated by oxidative stress and preventing mutations and genomic instability. MutM belongs to the Fpg/Nei family of procaryotic enzymes, sharing structural and functional similarities with their eukaryotic counterparts, such as NEIL1-NEIL3. Here, I present two crystal structures of MutM from pathogenic Neisseria meningitidis: MutM holoenzyme and MutM bound to DNA. The free enzyme exists in an open conformation, while upon binding to DNA, both the enzyme and DNA undergo substantial structural changes and domain rearrangement. One of the DNA lesion repaired by MutM is the Ap site, which, if not repaired, may spontaneously lead to the formation of an abasic site interstrand crosslink (Ap-ICL) with an adjacent adenine in the opposite strand. NEIL3 glycosylase is known to remove Ap-ICL. With a...
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In an Apartment in a small town, Mikulov
Solár, Michal ; Kozelský, Tomáš (referee) ; Hora, Jan (advisor)
The concept is based on the historical development of the plot and the city as such. Historically, the area has been defined by self-help and without clearly specified dogmatic guidelines. It is thanks to this that the city is enriched with moments that do not fulfill only the aesthetic or spiritual, but also the functional nature of the city. The moment of surprise and certain visas enriches the interior of the yard as well as the city. At first glance, such annoying spaces have a certain quality, caused by the play of light or the overall concept of space. An important feature of the object is the moment of surprise from the perceived space. The transition from a clearly defined ground floor to the rear, at first glance, irrational courtyard is enhanced by a passage, which also refers to the typical division of the small town house. ARCHITECTURAL SOLUTION The principle of layering of individual spaces clearly reflects the moments of surprise. By specific fragmentation of the building, a character that resembles rather a family house as a residential object, spaces of different quality and utilization are created. The lower dwellings have a spatially and optically separated garden from the total mass, with the top terrace being terraces which are optically linked to the courtyard, but are not accessible to the public. The apartments in the attic have mostly urban character. This creates the principle of co-existence, which is typical of the whole area of the city. The layering is evident in the distribution of flats with different connections to gardens and terraces as well as the variety of housing units. The spirit of the place is a standing cellar that reflects the historical transformation of the parcel and is a symbol of the locality.
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Reinforced concrete structure
Tesař, David ; Kraut, Jan (referee) ; Šulák, Pavel (advisor)
The aim of the master‘s thesis is static and structural design of polyfunctional house. The load will be determined according to ČSN EN 1990. The finite element method will be used for the calculation of internal forces. The design will be dimensioned according to ČSN EN 1992. Text part, static calculation and shape and reinforcement drawings will form the output of this work.
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Preparation of training materials for high voltage switchgears
Nosek, Jan ; Kozel, Tomáš (referee) ; Lázničková, Ilona (advisor)
This Bachelor thesis documents the creation of training materials for high voltage switchgear. Most of the work is devoted to introduction of products of ABB company, which the training materials are developed for. The main emphasis was on introduction of the UniGear ZS1 switchgear, which the main product of ABB's high voltage switchgear domain is. The last chapter is devoted to the analysis of the different levels of training materials.
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Residential Complex in Brno - Komín
Selnarová, Elisabeth ; Pospíšil, Zdeněk (referee) ; Boháč, Ivo (advisor)
Taking into consideration the slope of the terrain as well as the surrounding development, two types of residential buildings have been proposed: Komín a Komínek.They are placed in a regular structure into a given land. Sustainable development is at the core of the proposal. The residential buildings are proposed as sturctures created from multiple components. The framework is comprised of a reinforced concrete and the peripheral walls are stuffed with thermal insulating wooden panels. Air conditioned heating will be used (the air will be heated by a gas boiler). Due to the quality of the insolation, the houses are considered as low energy structures. As individual structures, each apartment has three sided orientation to cardinal direction. Some of the rooms have two sided lighting, which further increases their attractivness. The residential bulding is composed of Maisonette appartments, which together create asimilar structure. The fundamental space is intertwined with a ribbon that carries on its edges balconies, terraces or parking spaces. Each unit has a balcony, which allows the residence to relax and enjoy the surrounding landscape. The housing is proposed for a general audience (wider population). There are several types of appartments including no barrier appartments situated in the first floor as well as Maisonette appartments in the last floor.
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