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Analysis of digital modulation robustness at various types of interference
Uher, Tomáš ; Šilhavý, Pavel (referee) ; Kubánková, Anna (advisor)
This bachelor thesis concisely describes essential type of modulation technique for transmission of binary signal. In first part there are summarized advantages and disadvantages for each described modulation technique. There are described proceeding of modulation and demodulation too. Selected digital modulations are tested for Gaussian, Rice and Rayleigh transmission channels. In final part there are compared theoretical and measured values and summarized analysis.
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Commercial cellular networks for Critical Infrastructure
Uher, Tomáš ; Šilhavý, Pavel (referee) ; Krkoš, Radko (advisor)
This bachelor thesis discusses the possibilities of using commercial celluar networks to support the critical infrastructure of state, manufacturing and services. It also focus on special require ments for these systems. The last part of bachelor thesis deals with possibilites of support comummunication crtical end devices in the experimental celluar network of UTKO
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EEG Neurofeedback as an instrument to explore introspective correlates of cortical activity
Kaplan, Cyril ; Kulišťák, Petr (advisor) ; Nekovářová, Tereza (referee) ; Uher, Tomáš (referee)
Background: EEG neurofeedback is mostly used as a tool in clinical research and practice. Though many studies exploring the efficiency of neurofeedback training in treating distinct symptoms were performed, mostly adopting a design similar to clinical trials, many aspects of the whole process remain unclear as they are frequently neglected by and/or underreported in the published studies. Surprisingly, one of the first uses that the EEG neurofeedback was put to, had no clinical ambitions. The act of playing a simple sonic game with a goal to generate simple tones (by upregulating own alpha activity) served as a bridge for subsequent interviews targeting the subjective experience that accompanied the shifts in alpha oscillations. Objectives: The series of studies as a whole (a pilot and three studies) was designed around the instrument of EEG neurofeedback loop. The main objective was to capture the essence of subjective experience that accompanies rises and drops in the power of specific EEG features. Similarities and incongruencies in the character of subjective experience across subjects while interacting with the same EEG neurofeedback game were of interest, as well as the similarities and incongruencies in the subjective experience of one subject engaged in distinct EEG neurofeedback tasks....
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Immunological parameters in cerebrospinal fluid in children with autoimmune disorders of the central nervous system
Halmová, Hana ; Libá, Zuzana (advisor) ; Krejsek, Jan (referee) ; Uher, Tomáš (referee)
The central nervous system with its controlling and life-essential functions has a privileged position in our body. It has its own immune surveillance and is one of the immunoprivileged organs, in which immune reactions take place in specific ways. However, it is known that it is not entirely spared from immunopathological processes. Autoimmune diseases of the central nervous system are rare. Despite the growing diagnostic methods, the determination of an autoimmune aetiology of neurological disorders remains difficult. Thus, new diagnostic possibilities are constantly searched. The aim of this study was to investigate the levels of cytokines and chemokines in cerebrospinal fluid and serum in pediatric patients with various autoimmune diseases of the central nervous system as possible markers of inflammation. The contribution of our work is the potential in the use of cytokines and chemokines for the diagnosis of autoimmune diseases of the central nervous system when conventional diagnostic methods fail, as well as for the possible monitoring of the disease courses and the therapy effects. Our data may also contribute to the elucidation of the pathophysiology of individual diagnoses and to more effective and targeted therapy of these diseases in the future. Keywords: autoimmune diseases of the...
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Multiple Sclerosis - Neuropsychological markers for monitoring disease activity
Friedová, Lucie ; Uher, Tomáš (advisor) ; Holštajn Zemánková, Petra (referee) ; Libertínová, Jana (referee)
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that generates a wide range of clinical symptoms. These include cognitive impairment, a set of symptoms closely associated with the quality of life, which also serves as one of the most important predictors of limited ability to work. This doctoral thesis presents the output from four studies divided into three areas focusing on neuropsychological markers in connection to other manifestations and effects of MS. The first researched area is the link between speech characteristics and the information processing speed by patients with MS. Our study has proven a profound association between lower speed of articulation and below-average performance in terms of information processing speed. We have proven that acoustic quantitative speech analysis has the potential to identify patients with below-average cognitive performance. Another goal of this doctoral thesis was to ascertain the predictive value of serum neurofilament light chain levels in recently diagnosed patients with MS for the development of cognitive disorder within nine years of observation. During the period of observation, we uncovered only a loose link between high levels at the onset of the disease and the deterioration of cognitive functions in...
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Cognitive Deterioration in Otherwise Clinically Stable Patients with Multiple Sclerosis
Motýl, Jiří ; Uher, Tomáš (advisor) ; Světlák, Miroslav (referee) ; Hradílek, Pavel (referee)
Neuropsychological assessment of cognitive functions in multiple sclerosis (MS) is increasingly considered as an important paraclinical marker of disease stability or progression in MS. Recent recommendations pro-posed an annual screening of cognitive functions in all MS patients as a standard of neuropsychological monitoring in MS. There is a clear trend to diagnose possible disease progression as early as possible, to be able to respond quickly. The theoretical part of this thesis presents the current state of knowledge on cognitive impairment in MS, its correlates, predictors, and treatment possibilities. In addition, a comprehensive overview of the neuropsychological assessment and the diagnosis of cognitive deterioration in MS is presented. The highly relevant topics such as cutoff criteria of a meaningful change on individual neuropsychological examination, possibilities of treatment of cognitive deterioration, or the so-called isolated cognitive relapses, are discussed in a particular detail. The empirical part extends current knowledge in the field of MS. I present and discuss six original publications that follow these four main objectives: first, to describe the prevalence of isolated cognitive decline in MS and to put isolated cognitive decline in context with current knowledge on MS...
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Distinctive Features of Irish Accent
Uher, Tomáš ; Červinková Poesová, Kristýna (advisor) ; Ženíšek, Jakub (referee)
TITLE: Distinctive Features of Irish Accent AUTOR: Tomáš Uher DEPARTMENT: Department of English Language and Literature SUPERVISOR: Mgr. Kristýna Poesová ABSTRACT: The aim of this thesis is to examine the distinctive phonetic and phonological aspects of Irish English. The theoretical part provides a comprehensive description of the segmental and suprasegmental features of the Irish accent in contrast with the Received Pronunciation. The first section of the practical part analyses the speech of three Irish actors in Irish films and TV shows in order to examine the use of the distinctive features described in the theoretical part. The second section of the practical part presents a 45 minute long lesson plan on the Irish accent with suggested exercises for intermediate (B2) learners. KEY WORDS: accent, Irish, pronunciation, phonetics, phonology, lesson plan
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Psychoneuroimmunology of alexithymia
Uher, Tomáš ; Bob, Petr (advisor) ; Boleloucký, Zdeněk (referee) ; Smolík, Petr (referee)
Alexithymia represents a deficit in identifying and expressing emotions, paucity of fantasies, and an externally oriented cognitive style. Currently, numerous studies document that alexithymia and several mental and somatic disorders are significantly related. Several findings also indicate that this association might be caused by alexithymia related dysregulation of neuroendocrine and immune functions. Together these findings indicate that stressors related to alexithymia could underlie the process of neuroendocrine and immune dysregulation that likely may present a significant risk, sustaining and mediating pathogenesis of several disorders and particulary psychosomatic illnesses. In this context, it is also known that several proinflammatory cytokines may play a role in pain generation and that alexithymia is significantly associated with pain symptoms in several pain disorders. Following these findings this study includes several new data developing current state of the art and showing some alexithymia specific changes in patients with neurological disorders. Main finding of this study shows that alexithymia and anxiety in their specific interactions are linked to increased levels of interleukine-8 (IL-8) in cerebrospinal fluid (CSF) in the group of patients with non-inflammatory neurological...
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The effect of antitumor agents on the expression and activity of cytochrome P450 subfamily 2C
Uher, Tomáš ; Dračínská, Helena (advisor) ; Feglarová, Tereza (referee)
Targeted therapies, acting by blocking essential biochemical pathways required for tumor cell growth and survival, are being used lately in multiple cases of cancer treatment. Cabozantinib, a small molecule inhibitor of receptor tyrosine kinases, is an example of a targeted drug, regulating growth, angiogenesis and metastatic pro- gression of medullary thyroid cancer. Such drugs are also often complemented by cytotoxic agents, e.g. ellipticine; however, therapeutic usage of ellipticine itself is limited due to its poor solutibility and variety of adverse effects. In this bachelor thesis, effects of cabozantinib, ellipticine, or their combina- tion on gene and protein expression of cytochromes P450 2C6 and 2C11 have been studied in vivo. Aforementioned cytochromes have an important role in biotrans- formation of xenobiotics in rat liver. Their protein expression has been assessed by Western blot immunoassay technique, while the gene expression was evaluated by quantitative PCR method. Furthermore, the effects of studied substances and their combination on CYP2C6 and CYP2C11 specific activity have been determined by diclofenac 4'-hydroxylation and testosterone 16α-hydroxylation, respectively. Additionally, direct inhibitory effect of cabozantinib on recombinant CYP2C11 rat isoform has been studied in...
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Analysis of digital modulation robustness at various types of interference
Uher, Tomáš ; Šilhavý, Pavel (referee) ; Kubánková, Anna (advisor)
This bachelor thesis concisely describes essential type of modulation technique for transmission of binary signal. In first part there are summarized advantages and disadvantages for each described modulation technique. There are described proceeding of modulation and demodulation too. Selected digital modulations are tested for Gaussian, Rice and Rayleigh transmission channels. In final part there are compared theoretical and measured values and summarized analysis.
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