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National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Multiple Sclerosis - Neuropsychological markers for monitoring disease activity
 Friedová, Lucie ; Uher, Tomáš (advisor) ; Holštajn Zemánková, Petra (referee) ; Libertínová, Jana (referee)
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that generates a wide range of clinical symptoms. These include cognitive impairment, a set of symptoms closely associated with the quality of life, which also serves as one of the most important predictors of limited ability to work. This doctoral thesis presents the output from four studies divided into three areas focusing on neuropsychological markers in connection to other manifestations and effects of MS. The first researched area is the link between speech characteristics and the information processing speed by patients with MS. Our study has proven a profound association between lower speed of articulation and below-average performance in terms of information processing speed. We have proven that acoustic quantitative speech analysis has the potential to identify patients with below-average cognitive performance. Another goal of this doctoral thesis was to ascertain the predictive value of serum neurofilament light chain levels in recently diagnosed patients with MS for the development of cognitive disorder within nine years of observation. During the period of observation, we uncovered only a loose link between high levels at the onset of the disease and the deterioration of cognitive functions in...
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Boston Naming Test in preoperative examination in patients with pharmacoresistant temporal lobe epilepsy
 Libertínová, Jana ; Preiss, Marek (advisor) ; Šivicová, Gabriela (referee)
Theoretical part of this thesis concems Pharmacoresistant Temporal Lobe Epilepsy and Epilepsy surgery as an important option of the treatment of these patients. lt introduces respective methods used in complex preoperative diagnostics stressing the neuropsychological preoperative examination. Majority of basic cognitive functions - memory, speech and IQ - are lateralised. Functionality of temporallobe is reflected by ability of naming. We introduce the Boston Naming Test (BNT) used in preoperative diagnostics of pharmacoresistant epilepsy patients to locate the epileptogenic region. Empirical part concems Czech adaptation and standardisation of BNT and describes pivotal study with 38 healthy persons and 38 patients with temporal lobe epilepsy. Main objective was to check criterial validity ofBNT" Statistical analysis shows highly significant differencies between scores of healthy controls and epilepsy patients. (p < 0,000). Test shows 80% sensitivity and 92% specificity.
Detailed record
Boston Naming Test in preoperative examination in patients with pharmacoresistant temporal lobe epilepsy
 Libertínová, Jana ; Šivicová, Gabriela (referee) ; Preiss, Marek (advisor)
Theoretical part of this thesis concems Pharmacoresistant Temporal Lobe Epilepsy and Epilepsy surgery as an important option of the treatment of these patients. lt introduces respective methods used in complex preoperative diagnostics stressing the neuropsychological preoperative examination. Majority of basic cognitive functions - memory, speech and IQ - are lateralised. Functionality of temporallobe is reflected by ability of naming. We introduce the Boston Naming Test (BNT) used in preoperative diagnostics of pharmacoresistant epilepsy patients to locate the epileptogenic region. Empirical part concems Czech adaptation and standardisation of BNT and describes pivotal study with 38 healthy persons and 38 patients with temporal lobe epilepsy. Main objective was to check criterial validity ofBNT" Statistical analysis shows highly significant differencies between scores of healthy controls and epilepsy patients. (p < 0,000). Test shows 80% sensitivity and 92% specificity.
Detailed record

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