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Chalcones and their analogues as potential drugs X.
Richterová, Lenka ; Opletalová, Veronika (advisor) ; Kučerová, Marta (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate Mgr. Lenka Richterová Consultant Assoc. Prof. RNDr. Veronika Opletalová, Ph.D. Title of Thesis Chalcones and their analogues as potential drugs X. Theoretical part of the thesis is devoted to current possibilities in the treatment of mycoses. Some examples of natural chalcones with antifungal properties are given, and various modifications of their structures and the influence of these modifications on antifungal activity are described. Experimental part deals with the synthesis of fluorinated (2E)-3-phenyl-1-pyrazin-2-ylprop-2-en-1-ones (Obr. 1). N N O R 1 R 2 R1 = H, tert-butyl, isobutyl, butyl, propyl R2 = 2-F, 4-F Obr. 1 Structure of the studied compounds The compounds were obtained by the Claisen-Schmidt condensation in pyridine using diethylamine as condensing agent. The syntheses yielded one compound already reported in literature and four novel analogs. The structures of the products were corroborated by means of IR a NMR spectra and their purity checked by melting point and elemental analysis. Antifungal activity of the prepared compounds was evaluated by microrodilution broth method against eight strains of pathogenic fungi. The highest potency in both...
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Folk crafts movement in Japan and its leading representatives
Richterová, Lenka ; Sýkora, Jan (advisor) ; Labus, David (referee)
Jako téma své bakalářské práce jsem si vybrala hnutí za záchranu lidových řemesel- mint;eiv Japonsku s dúrazem na keramickou tvorbu jak historickou, tak tvorbu hlavních představitelú hnutí. Nejprve chci chronologicky představit keramickou historii na japonských ostrovech, vznikání dílen, proudú, které chci v rámci kategorií rozlišit na keramiku lidovou- mingei a uměleckou (čajovou), a načrtnout mezi nimi rozdíly, které chci v praktické části demonstrovat ukázkami. Poté chci představit společenské události restaurace Mcid7,i a jejich vliv na řemeslnou tvorbu a utváření názorových skupin na počátku 20.století, jejich vývoj, tendence a názory. Následně se zaměřím na vznikající vztahy mezi hlavními představiteli budoucího hnutí, utváření jejich názorú a tvúrčích začátkú až do vzniku hnutí v roce 1926. Po vzniku hnutí chci dále chronologicky představit jeho činnost ve 30. letech, zásluhy, objevitelskou činnost, popřípadě neshody v poválečných letech až do rozpuštění hnutí a také tvorbu hlavních umělecky činných představitelů. V další části mám v úmyslu podrobně popsat koncept mingei, jak ho v knize "The unknown crajisman'" popsal .lanagi Sóecu, s ohledem na všechny aspekty, které lidový výrobek utváří, a také jej chci umístit do kontextu japonské estetiky. V předposlední části se zaměřím na povahu hnutí...
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Current options of treatment for parasitic kinetoplastids
Čadková, Aneta ; Mach, Jan (advisor) ; Richterová, Lenka (referee)
Chagas disease, sleeping sickness and leishmaniasis are diseases occurring mainly in developing areas of Africa, America and Asia. They are caused by parasitic kinetoplastids from the genus Trypanosoma and Leishmania. These protozoans undergo morphologic transformations during their development leading to changes of their properties. They are characterized by complex mechanisms that allow them to evade the host's immunity. At the same time, because of these mechanisms and selection pressures, they are able to subsequently develop resistance to used drugs. The diseases caused by protozoa are classified as "neglected tropical diseases". The research and development of drugs against them is heavily underfunded. Currently used drugs are expensive, have a number of side effects, and due to lack of usage regulation develop resistance. The work first generally presents human parasites of the class Kinetoplastida. It further describes the treatment of diseases caused by the characterized species and focuses on a summary of currently used drugs, their mechanism, resistance and potential new drugs in clinical phases. Key words: kinetoplastids, Trypanosoma, Leishmania, treatment, disease, mechanism of action, resistance, nitroreductase
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Addictive behavior on the Internet in relation to family environment in students of 7th-9th grades of primary schools in Pribram
Majerová, Žaneta ; Vacek, Jaroslav (advisor) ; Richterová, Lenka (referee)
Background: The Internet has become a regular part of our everyday life. Its use carries not only many indisputable advantages, but also certain risks - addictive behavior being one of them. Therefore, it is not surprising that many studies deal with this issue. Although several foreign studies have examined the connection between this phenomenon and selected factors of the family environment, I have not observed any such specific study in the Czech Republic. Aims: The aim of the theoretical part of this thesis is to provide information about an addictive behavior on the Internet, the family and its role in the life of an individual, in order to introduce the studies that have already been carried out. These were concerned with selected factors of the family environment in connection with addictive behavior on the Internet. The practical part of this thesis consists of my own research aimed at finding the prevalence of addictive behavior on the Internet and examining the connection between this phenomenon and the respondents' gender, divorce of parents, parents' education and types of family. Methods: The aims of the theoretical part of this bachelor thesis were achieved with the study of selected literature. Furthermore, the questions of the practical part were answered on the basis of evaluation...
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Initial interview with addicted people in the context of psychodynamic approach
Richterová, Lenka ; Šťastná, Lenka (advisor) ; Miovský, Michal (referee)
Background: A initial interview with addicted people is described as a mapping of the patient's risk behavior in relation to the use of addictive substances. It also includes an assessment of the overall condition of the patient and subsequent determination of the therapeutic plan. It is a complex examination that which takes time for 60 minutes. The question is what should we do in this interview. How to make a plan for treatment with the patient. Objective: The aim of this thesis is to propose the structure of an aditological examination for the outpatient treatment center named Adiktologicka ambulance. The next step is to do the verification of the interview in practice. Methods: On the basis of professional literature, we formulate the possible contents of the "adictological input" exercise. We are interested not only in what to do but also how. We work in a psychodynamic context. Subsequently, we propose initial interview for addected people in the outpatient treatment center for addiction. We highlight the importance of the institutional context. The interview must match the focus and tasks of the certain institution. Finally, we briefly present the experience of the worker with addicted people. Discussions and Conclusions: We found out that an initial examination took more than one hour....
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Severe clinical manifestations of therapeutic communities clients in the context of ADHD
Richterová, Lenka ; Šťastná, Lenka (advisor) ; Miovský, Michal (referee)
This Bachelor thesis is a sub research of the wider project focused on the impact of ADHD on selected mental functions, life skills and quality of life of the clients recovering from an addiction in the therapeutic communities. ADHD is associated with inferior adaptability and as well with more serious psychopathological symptoms. The aim of the research is to determine whether ADHD occurs in clients of the therapeutic communities and what is the prevalence. Furthermore, we search for connections with other serious clinical manifestations and evolution of these symptoms during treatment. We are also interested in retention of the clients with these symptoms in treatment process. The sample was compiled on the basis of the two-step procedure. Fundamental file in the first phase were all certified therapeutic communities for the addictions treatment. Among them were by computer randomly selected eight who participated in the research. At the second level was used a total choice of new coming clients and all of them were tested. The number of participants who filled their gender is 199. 133 men and 56 women. Data were collected directly by therapists in eight therapeutic communities. Specially designed test battery was administered after two weeks of treatment, then after three, six and nine months....
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Chalcones and their analogues as potential drugs X.
Richterová, Lenka ; Opletalová, Veronika (advisor) ; Kučerová, Marta (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate Mgr. Lenka Richterová Consultant Assoc. Prof. RNDr. Veronika Opletalová, Ph.D. Title of Thesis Chalcones and their analogues as potential drugs X. Theoretical part of the thesis is devoted to current possibilities in the treatment of mycoses. Some examples of natural chalcones with antifungal properties are given, and various modifications of their structures and the influence of these modifications on antifungal activity are described. Experimental part deals with the synthesis of fluorinated (2E)-3-phenyl-1-pyrazin-2-ylprop-2-en-1-ones (Obr. 1). N N O R 1 R 2 R1 = H, tert-butyl, isobutyl, butyl, propyl R2 = 2-F, 4-F Obr. 1 Structure of the studied compounds The compounds were obtained by the Claisen-Schmidt condensation in pyridine using diethylamine as condensing agent. The syntheses yielded one compound already reported in literature and four novel analogs. The structures of the products were corroborated by means of IR a NMR spectra and their purity checked by melting point and elemental analysis. Antifungal activity of the prepared compounds was evaluated by microrodilution broth method against eight strains of pathogenic fungi. The highest potency in both...
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Transformation of the Traditional Folk Crafts in Japan in the 20th Century
Richterová, Lenka ; Sýkora, Jan (advisor) ; Labus, David (referee)
Japan, as a country with remarkably strong tradition of craftsmanship, undertook significant changes in this area in the 20th century. One of the main areas in this field is a Japanese folk pottery. The aim of this paper is to present how the ceramic craft and all its aspects transformed from the Meiji Restoration to the present. Firstly, it focuses on introducing the styles of folk pottery and the way traditional potters in the Tokugawa period worked, then it focuses on various influences which affected the field and the changes that brought. In the final part, the work focuses on the description of ceramic craft nowadays, the comparison with the past and tries to contemplate on the philosophy of tradition.
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