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Study of influence of hydroxyethylcellulose on eye drops weight
Sváčková, Radka ; Šklubalová, Zdeňka (advisor) ; Zatloukal, Zdeněk (referee)
Study of influence of hydroxyethylcellulose on eye drops weight Radka Sváčková Abstract: The purpose of the work was a study of influence of hydroxyethylcellulose ingredient on weight of eye drops various dripping adapters, made of gum and plastic, in two different angles of dripping of concentration line 0,16 - 0,75 % HEC solution with 6 - 98 Pa.s range of viskosity there was found out the weight of the drops and compared to the weight of water drops gained under the same experimental circumstances. In the three - factor screening experiment there was found out that between non-water adapter is no evident diference, both of them during vertical dripping water drops of aproximately same weight (43,5 mg). The weight of drops significantly rised up with HEC ingtedient due to watering of surface of dripping part of both adapters. Watered gum adapter produced significantly larger drops than watered plastic adapter with both kind of dripping angles. The weight of drops significantly went down for both studied adapter with reducing the dripping angle from 90ř to 45ř. There was found out in this detail study quite large rising of the eye - drop weight with present of HEC ingredient of concentration range 0,16 - 0,75 % in comparison to the weight of water drops for both dripping adapter. The largest drops with...
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Education of Non-medical Staff - System of Education of Nurses in the Health-service Organization
Molčanová, Andrea ; Vrzáček, Petr (advisor) ; Vylitová, Lucie (referee)
The Master's Thesis deals with the description of the system of education and development of the non-medical staff workers, especially, the sub-group of General Nurses. In the theoretical part the work gives a general view of the position and significance of education in the health-service organization. Systematic education of health-service workers brings a number of benefits for the Patients, the organization and the worker himself. It supports the provision of quality health care that is directed at an improvement of the health condition of the Patient. Further, it brings satisfaction of well performed work for the staff, success of the whole health-service organization and an improvement of the quality of the health for the society. The research part of the Master's Thesis answers to the previous lines by an assessment of the system of education of General Nurses in The Institute Hematology and Blood Transfusion in Prague. The objective of the investigation was to analyze how the current system of education works and what is the interconnection of the individual procedures of the whole system. The methodological basis for obtaining data was an analysis of documents, questionnaire investigation and structured interviews. The found data showed that, despite the fact that the basic procedures of the system...
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The kinds of identity in the Czech interwar romance
Svobodová, Marta ; Heczková, Libuše (referee) ; Bílek, Petr (advisor)
The graduation thesis focuses on the types of social identity created between the lines of the story about the romantic love. The selected books (the thesis choose the texts, which were published as books, although there is also a huge range of texts published as part-issues) fall into the works of the most popular writers in the interwar era in the new established Czechoslovakia (Javořická, Zahradník-Brodský, Utěšitelová, Kyzlinková etc.). The analysis of the texts shows, that the period, when they were published, influences the social meaning of the concepts used as motives, which sketch in the dramatic or on the other hand the lyric atmosphere. The new established state as the new social-political organization uses the metaphors of the Czech national revival as social stereotypes to remake and reinforce the Czech national identity. Though there are other types of identity as local identity, religious (Christian) or gender identity, they all at least partly embody in the changed national identity.
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Gene silencing of ICAM-1 by lysine modified oligonucleotides
Kocourková, Aneta ; Štaud, František (advisor) ; Nachtigal, Petr (referee)
Conjugation of ligands to antisense oligonucleotides is a promising approach for enhancing their effects on gene expression. In this study 2'-O-lysylaminohexyl group was linked to the uridine base, which replaces one, two or three thymine bases thus modifies the oligonucleotides. This exchange of bases was tested for improvement of silencing target protein expression. Effectivity of modifications in silencing target protein expression was examined with the alicaforsen sequence (DNA) and siRNA. Alicaforsen, currently in clinical trial 3, is a phosphorothioate targeting ICAM-1, which was the model used to evaluate the influence of modifications. The same target was chosen for siRNA to compare the efficiency of DNA and siRNA substances. For the first time, down-regulation of ICAM-1 was shown on the blood brain barrier cell line ECV304. Unmodified/modified antisense oligonucleotides and siRNA sequences were transfected into ECV304 cells with the help of a transfection agent lipofectamine 2000. After 24 hours of transfection cells were disrupted by a chemical lysis. Protein concentrations were determined by Bradford protein assay. ICAM-1 inhibition was assessed with western blot. The inhibitory effect of ICAM-1 was normalized to the corresponding actin and untreated cells. ICAM-1 protein levels were...
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Municipal transportation system of Nitra
Podoláková, Petra ; Zelený, Lubomír (advisor) ; Škarbala, Daniel (referee)
The thesis is divided into two parts of which the first is the theoretical one. The beginning of the work concerns with the transportation and its history in Slovakia. Next, the basic notions of public transportion and its subsystems are characterized. After dividing the public transportation, this thesis is dealing with Nitra municipal public transportation. Next, there are defined its basic notions and also the municipal transportation public system. The second part of this thesis is practical. It begins with the the description of Nitra and its history and presence concerning the transportation system. After that, the municipal transportation system of Nitra -- its network of lines, stops, its travelling guide, information systems, tariffs, vehicular park and aims of the transportation its analyzed. This capitulum finishes with the survey part, which deals with the satisfaction of the passengers. The aim of this thesis tries to analyze the municipal transportation system of Nitra. On the other, hand it is the survey of the satisfaction of passangers through the surveys.
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Ecological marketing
Neznaj, Radek ; Procházka, Jan (advisor) ; Pešek, Ondřej (referee)
The work addresses issues of ecological marketing, specifically focuses on the marketing mix of organic products. The intention is to point out guidelines and outline options that may be the potential of products development in line with environmental objectives and the enterprise. The work is divided into three parts. The first part briefly shows the evolution of marketing and its current form, including current trends and events that led to the emergence of ecological marketing. This section defines the ecological marketing objectives. Second, the main part of this work shows the ecological marketing mix in the ordinary formulation: product, price, place and promotion. Attention is paid to all individual elements of the mix, their advantages, disadvantages and the key aspects in the use of ecological products and where possible, illustrated on practical examples. The last part consists of two case studies. The first one is focused on design and packaging at Hewlett-Packard, namely multimedia notebook HP Pavilion for Walmart. The second is focused on the Toyota and its Prius hybrid model in order to analyze key aspects of the success of this model on the market of hybrid cars. The conclusion summarizes the key aspects of ecological marketing and suggests possible development for the future.
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Age related macular degeneration - modern diagnostic and therapeutic preventive approach
Gogelová, Blanka ; Souček, Petr (advisor)
Age-related macular degeneration (AMD) is a disease associated with aging that gradually destroys sharp, central vision. Central vision is needed for seeing objects clearly and for common daily tasks such as reading and driving. AMD affects the macula, the part of the eye that alows seeing of fine details. AMD occurs in two form: dry and wet. In dry AMD, the light sensitive cells in the macula slowly break down. As fewer cells in the macula are able to function, people will see details less clearly in front of them, such as faces or words in book. Dry AMD often occurs in just one eye at first. Later the other eye can be affected. The most common early sign is blurred vision. The dry form is much more common. More than 85 % of all people have thy dry form. Once dry AMD reaches the advanced stage, no form of treatment can prevent vision loss. The National Eye Institute's Age-Related Eye Disease Study (AREDS) found that taking a specific high-dose formulation of antioxidants and zinc significantly reduces the risk of advanced AMD and it's associated vision loss. Wet AMD occurs when abnormal blood vessels behind the retina start to grow under the macula. Damage to the macula occurs rapidly. With wet AMD, loss of central vision can occur quickly. The classic early symptom is that straight lines appear crooked...
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Design and innovations: Conditions and qualities of cooperation between companies and designers
Matějková, Kamila ; Kubaš, Mario (advisor) ; Hucková, Barbara (referee)
The diploma thesis deals with design as part of creative economy and design in the context of corporate innovations. The aim is to analyze the conditions and qualities of cooperations between companies and designers in the Czech Republic, to identify barriers to effective collaboration and to propose steps leading to development of cooperation between businesses and designers. Tool for the analysis is research in the form of a questionnaire survey among Design Competitiveness programme participants, which the agency CzechTrade implemented in 2013 and 2014 to support projects of cooperation between companies and designers. Conditions and qualities of cooperation is explored in the following aspects: establishment of cooperation, objectives and results of the collaboration, progress of the cooperation and obstacles to effective cooperation. The research is complemented by a case study of a specific project of such cooperation, the development of a new product line by the Mikov company.
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BTL marketing communication and its importance for brand building
Bindzarová, Lucie ; Machek, Martin (advisor) ; Kolouchová, Daniela (referee)
The topic of the thesis deals with BTL marketing communication and its importance for brand building. The aim is to analyze tools of BTL marketing communication on the Czech market and identify the most effective tools that can be used to build brand in the FMCG environment. The thesis should provide more details about below the line communication and its increase use market positioning. Also identify appropriate tool for building brand image, quality and raising customer awareness. Research, expert interviews and case studies were used to prove the objective of this thesis.
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