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Effects of chemopreventive compounds on cytochrome P450s
Křížková, Jitka ; Hodek, Petr (advisor) ; Helia, Otto (referee) ; Václavíková, Radka (referee)
CHARLES UNIVERSITY IN PRAGUE Faculty of Science Department of Biochemistry Effects of chemopreventive compounds on cytochrome P450s Summary of Ph.D. Thesis RNDr. Jitka Křížková Supervisor: prof. RNDr. Petr Hodek, CSc. Prague 2010 Introduction 1 Introduction According to the World Health Organization statistics, cancer is one of the leading causes of death in the human population worldwide for more than 50 years. Moreover, colorectal and gastrointestinal tract cancers are one of the main types of cancer leading to overall cancer mortality. Prevention consisting in a healthy lifestyle and a natural diet is suggested to be one of the main approaches to reduce cancer risk. In recent years, the consumption and use of dietary supplements containing concentrated chemopreventive phytochemicals increased dramatically. Flavonoids, as the most popular representatives of chemopreventive compounds, present in foods (fruits, vegetables, herbs, beverages) and dietary supplements have the potential to modulate the activity of xenobiotic-metabolizing enzymes [Hodek et al., 2002]. Among proteins interacting with flavonoids, cytochrome P450s (CYPs), monooxygenases metabolizing xenobiotics (e.g. drugs, carcinogens), play the most prominent role. The two members of CYP1A subfamily, CYP1A1 and CYP1A2, are involved in the...
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Calculation of parameters of small induction motor
Vojče, Zbyněk ; Cipín, Radoslav (referee) ; Vítek, Ondřej (advisor)
This bachelor thesis deals in the first part with a construction and a principle of function of an induction motor. In the second part deals with an actual analytical calculation of three-phase low power induction motor. Is performed a simulation in a program Ansoft RMxprt, which calculated the characreristics of the motor analytically and simulation in program Maxwell 2D by finite element method. The aim of the work is to compare results of simulations with results of analytical calculation.
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Efficiency Improvement of Small Induction Motors
Vilím, Martin ; Veselka, František (referee) ; Hájek, Vítězslav (advisor)
In this bachelor´s thesis I discuss about asynchronous engines in general, describe their construction and principle of operation, using. It also includes measurements of a specific motor and design engine. The first part deals with theprinciple of the engine options including the fundamental control over speed and torque. The second part deals with the measurement of the size of the searchengine and losses. The last part provides a proposal for a new induction motor.
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Connection of elektrothermal devices to the network
Sumka, Martin ; Lázničková, Ilona (advisor)
This thesis devotes with electrothermal devices and their behavior when connected to the network. It describes the basic types of electrothermal equipment, their structure, construction, principle of converting electrical energy into heat energy and goings that occur during their operation. It also examines the basic types and ways of dealing with compensation and symmetrization applied on different types of electrothermal equipment. It explains the basic methodology used for design of compensation and symmetrization of particular electrothermal equipment and components.
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DC/DC step-up converter for notebook
Škunda, Michal ; Klíma, Bohumil (referee) ; Červinka, Dalibor (advisor)
Given bachelor’s thesis devoted to a proposal and implementation of transducer STEP-UP for supplying of notebook in car. Introduction presents dividing of switching power supplies followed by a choice and a proposal of power supply. In this work we can find the specific proposal of inductor, the proposal of electronic connexion and the proposal of PCB layout. There is a software EAGLE used for the design of PCB layout. In the last part of work there are particular courses of current and voltage that characterize power supply pictured. The work contains measured load characteristic of switching power supply loaded by notebook as well. Notebooks need to have quality power supplies that is why there was a special attention paid to the quality of supply and its electric parameters.
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Unit for wireless transmission of electrical energy
Jelínek, Aleš ; Kopečný, Lukáš (referee) ; Žalud, Luděk (advisor)
The aim of this work is to prove the practical applicability of the concept of contactless energy transfer using induction coils. The first part deals with the mathematical model and theoretical proof of the concept being able to work in practice and describes the process of detecting resonance of receiver circuit on transmitter side. Next chapter describes hardware solution of the experimental prototype. The last part contains measurement results of a coupling coefficient of coils and discusses performance and notable features of the prototype.
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Design of high-speed induction motor
Svoreň, Jan ; Ondrůšek, Čestmír (referee) ; Vítek, Ondřej (advisor)
This work deal with troubleshooting of problem parts of high-speed induction machines. Introduction is about conception of induction machines with reference to construction specialities due to high rpm and because machines are fed by inverter. Next part is focused to design problems. A classical induction machine was measured to determination change of various losses in classic and high-speed induction machines. The computation of laboratory sample high-speed motor was specified for calculation of effective resistance and leakage reactance of solid-steel rotor with copper layer. The results of numerical calculation were validated by using finite elements method and machine design was adjusted for improving operation characteristic.
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Measurement of conductivity of liquids
Mašláň, Stanislav ; Havránek, Zdeněk (referee) ; Beneš, Petr (advisor)
The first part of thesis is theoretical and it is the introduction into conductometry. It defines the essential terms of this field as well as contact and contactless methods of measurement of fluid conductivity and also the influential parasitic phenomena and possibilities of their elimination. The second part is dealing with design of the contactless transformer conductivity probe. The characteristics of designed probe are verified in the practical part of the thesis. The final part of the thesis is dealing with measurement according to the defined points in the assignment. The characteristics of several contact probes are verified and also the characteristic of the contactless transformer probe, which was implemented according to the design from the second part. Outcomes of these measurements establish the suitable power supply frequencies and currents for all these probes.
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The simulation of steel rod improvement by the induction lines heat treatment
Chmiel, David ; Turoň, Rostislav (referee) ; Kouřil, Miloslav (advisor)
Bachelor thesis deals with possibilities of simulation of induction heat treatment. Literary analysis is focused on the method of induction treatment, the physical nature and its use for the heat treatment. For completeness is in the end comparison of different methods of heat treatment. The experimental part describes the future of quenching and tempering of steel bars in company Třinecké železárny a.s. Also is contained method of simulation of the heat treatment in computer program QTSteel and the subsequent design of parameters for a continuous processing.
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