|
Cutting ceramics and its effective use
Kavalír, Vít ; Sedlák, Josef (referee) ; Humár, Anton (advisor)
Master’s thesis are concerned with the cutting ceramic materials and its ef-fective usage. The first part of the thesis is focused on the general properties of the cutting ceramics, its history, development, production and description of the various types. This part includes as well a description of the mechanic-physical properties and the potential of the usage for machining. The second part of the work solves the general evaluation of the cutting power. The main issue in the next part is the identification of cutting ceramics range and the selection accor-ding to main world producers. The fourth part deals with the assessments and the comparison of the working conditions for different types of the machined ma-terials. The technical economic assessment shows the potentials in the total pro-duction costs reduction.
|
|
Antimicrobial effect of agents predestined for prevention of contamination V.
Lepíková, Pavla ; Jílek, Petr (advisor) ; Křivčíková, Lucie (referee)
This thesis deals largely with the influence of UV radiation on the antimicrobial effects of several paint coats, which differed only varying concentrations of zinc oxide. Therefore, the relationship of concentration of oxide to the antimicrobial effects was studied, too. In this work, paints were tested by three different methods. As the test microorganisms were used S. aureus, E. coli and C. albicans. Using the first method, tested paints were not irradiated with UV light at all. Using the second method, paints were irradiated 30 minutes before applying the bacterial suspension. Using the third method, tested paints were irradiated simultaneously with bacterial suspensions. After cultivation of removed samples, CFU numbers were determined. By processing the values was found that the paints tested using the third method had the best effect. Thus the influence of UV radiation on the antimicrobial properties of the examined paints was proved. Results also showed that the most effective paint contained 7.9% ZnO. Testing demonstrated the greatest sensitivity of Gram-negative bacteria E. coli. The paints had the smallest antimicrobial effect on C. albicans.
|
|
Study of chemiluminescence properties of metformin using sequential injection analysis
Horáková, Markéta ; Sklenářová, Hana (advisor) ; Chocholouš, Petr (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of analytical chemistry Candidate: Mgr. Markéta Horáková Consultant: PharmDr. Hana Sklenářová Ph.D. Title of Thesis: Study of chemiluminescence properties of metformin using sequential injection analysis Chemiluminescent properties of metformin were studied using a sequential injection analysis in the three systems with different composition of the reagents. The first system used potassium permanganate and sulfuric acid, the second cerium sulfate tetrahydrate and (tris (2,2 '-bipyridyl) dichloro-ruthenium hexahydrate. The third system used the N- bromsukcinimid and fluorescein. The flow rate, concentration and volumes of reagents, scheme of the measuring cycle and used solvents have been optimized into the first two systems. The concentration of N-bromosuccinimide (NBS) and fluorescein in the third system were based on data found in literature [Zhouping Wang, Anal. Lett. 2003]. The volume and speed were detected automatically using the program FaFSIAOptim, created the Department of Analytical Chemistry. Scheme of the measuring cycle was optimized in the same way as in the previous two systems. During the optimization, and subsequent measurements revealed that the only suitable system is the third system with NBS and...
|
|
Nová HPLC metoda pro stanovení nafazolinu v očních přípravcích
Dulavová, Martina ; Chocholoušová Havlíková, Lucie (advisor) ; Matysová, Ludmila (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Martina Dulavová Supervisor: PharmDr. Lucie Havlíková, Ph.D., Ass.Prof. Hannelore Kopelent Title of Diploma Thesis: A New Selective and Stability Indicating HPLC Assay for the Determination of Naphazoline in Preparations for Ocular Use Naphazoline is a 2-imidazolidine derivated drug and alpha-adrenergic agonist with vasoconstrictive and decongestive properties. Naphazoline is indicated for the therapy of rhinitis, sinusitis or allergic conjunctivitis. Naphazoline is used in liquid formulations for ophthalmic and nasal application. Naphazoline is marketed in a number of commercially available products; for example, it is contained in Coldan® Augentropfen. Due to economic and therapeutic reasons, hospital pharmacies produce miscellaneous in-house preparations. For our study, two different preparations manufactured in the sterile production of a hospital pharmacy containing naphazoline are investigated. The first formulation is based on two commercially available products and it is a mixture of Coldan® Augentropfen and Okuzell® Augentropfen at a ratio of 1:9. The second formulation is Bor-Naphazolin Augentropfen and it is completely prepared in a hospital pharmacy. In addition to...
|
|
Applications of chiral and achiral chromatography in pharmacology and toxicology
Chytil, Lukáš ; Slanař, Ondřej (advisor) ; Bultas, Jan (referee) ; Coufal, Pavel (referee)
Development and validation of methods for analysis of several drugs or their metabolites are decribed in this thesis. The document is presented as a commentary to the original papers, which were published in peer reviewed journals. Discussion on the optimization of each method is presented and covers also method development and influence of preanalytical aspects. Additionally, examples of the application of the developed methods in clinical pharmacology and toxicology are shown. This dissertation consists of three parts: enantiomeric determination of tramadol and its metabolite, determination of some antihypertensive drugs, and qualitative analysis of benzodiazepines. Development of a method for chiral analysis of tramadol and its desmethylated metabolite O- desmethyltramadol (ODT) in human urine and plasma is described in the first part of the thesis. Tramadol is a centrally acting analgetic drug, which is used as racemate in clinical practise. Each enantiomer displays different binding properties for various receptors: (+)-tramadol preferentially inhibits serotonin reuptake while (-)-tramadol mainly inhibits noradrenalin reuptake. (+)-tramadol is considered 10-times more potent than (-)-tramadol. Major active metabolite (ODT), which is considered to be the main agent responsible for the...
|
|
Weighted rearrangement-invariant spaces and their basic properties
Soudský, Filip ; Pick, Luboš (advisor)
In this thesis we shall provide the reader with results in the field of classical Lorentz spaces. These spaces have been studied since the 50's and have many applications in partial differential equations and interpolation theory. This work includes five papers. The first paper studies the properties of Generalized Gamma spaces. The second paper provides an alternative proof of normability characterization of classical Lorentz spaces. The third paper discusses conditions of linearity and quasi-norm property of rearrangement-invariant lattices. The following paper gives a characterization of normability of Gamma spaces. And finally the last paper characterizes the embeddings between GΓ spaces. 1
|
|
Wavelet Wiener filter of ECG signals
Sedláčková, Eva ; Odstrčilík, Jan (referee) ; Smital, Lukáš (advisor)
The aim of this work is introduction with method of filtering the ECG signals using wavelet transformation and use of this method for filtering of signal disturbed with myopotencials. The work deals with general properties and with genesis of ECG signals and describes ECG curve. Next part of work is focused on wavelet transformation, types of wavelet transformation and different methods calculation thresholds and thresholding. Design part of work is focused on design Wiener filter for remove myopotencials from ECG signals and finding optimal parameters of this filter using optimization algorithm. For optimization is used simplex method. Discovered optimal parameters are assessed on CSE and MIT-BIH Arrhythmia database and compared with results of other authors.
|
|
Is the Concept of the Laffer Curve Valid ?
Herbst, Karel ; Schneider, Ondřej (advisor) ; Hedbávný, Petr (referee)
i Abstract This thesis deals with the issue of Laffer curve. According to the idea of the Laffer curve when the tax rate exceeds certain treshold (revenue-maximizing tax rate) the tax revenue would in absolute terms decrease with rising tax rate. Therefore this thesis tries to discover whether those facts are valid in the corporate income taxation for 20 OECD countries for the time period from 1965 to 2006. The structure of the thesis could be divided into three parts. In first introductory chapters the issue of taxation would be discussed in general. It will briefly examine the history of taxation and explore the theory of taxation and tax systems. The second part of this thesis will focus on the Laffer curve in detail. Third chapter will introduce the theory behind Laffer curve and discuss its properties for different types of taxation. In the following chapter the literature and different possibilities of estimation of the Laffer curve and (or) Laffer effects would be reviewed. Fifth chapter focuses on the corporate income taxation per se and examines the development of corporate income tax revenue and rates in our sample countries. In the last part of this thesis the econometric estimates of the Laffer curve for corporate income taxation are presented. The Laffer curve would be estimated for three...
|
|
Mortgage Banking
Habrová, Marta ; Kovář, František (advisor) ; Votava, Libor (referee)
This bachelor work is focused on mortgages in the Czech Republic. Mortgages generally are described at the beginning of my work - their characteristics, properties and kinds. Approval procedure of mortgages is described in another part of work (from request for loan to mortgage repayment). Practical part of my work includes comparison of products of mortgage banks, which I made from the point of view of advantages for customers. This work deals with the theme of financial crisis in the mortgage market, which have started in the USA in 2008.
|
|
Mortgages in Czech republic
Shchukina, Marina ; Smrčka, Luboš (advisor) ; Schönfeld, Jaroslav (referee)
This diploma thesis discusses about possibilities of housing financing and is especially focusing on mortgage market in Czech Republic. First part of this thesis has theoretical character and describes different types of housing: property housing, cooperative housing and rental housing and their specific features. This part also contains general characteristics of the basic ways of housing financing: building saving and mortgages. Besides, building savings is here compared with mortgages and there are described advantages and disadvantages of those both possibilities of housing financing. In this part there are also put examples of "future mortgages", which are not offered by Czech banks yet. The second part of the diploma thesis is focusing its attention on actual world crisis. Defines reasons of its origin, describes its impact on European and Czech economy. Also, discusses about impact the actual crisis has on estate market and market with loans and mortgages in Czech Republic. The third part of the thesis is concerned on standard procedure while disposing the mortgage and contains short example of buying an apartment by fictive person.
|
guest ::
