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Competitiveness and Innovativeness of Economy
Olexa, Ján ; Vítek, Leoš (advisor) ; Bayer, Ondřej (referee)
The very first aim of this bachelor thesis is to analyse the competitiveness and innovativeness of the Czech Republic and Austria. Theoretical part is dedicated to description of different methods used for measuring the competitiveness focusing on its indicators with emphasis on the innovativeness. Practical section deals with the Czech and Austrian competitiveness using approach drawn by World Economic Forum - this paper compares them underlining their current differences trying to reason the present state of them both. At the end, the reader can find future GDP PPP predictions showing the diminishing gap between the Czech Republic and Austria.
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Activities of CzechTrade agency in selected markets
Dudová, Zdena ; Plchová, Božena (advisor) ; Šuchman, Jaroslav (referee)
The goal of this paper is to analyse the activities of CzechTrade agency on the Brazilian and Mexican markets. The first chapter deals with the position of the Czech Republic in international trade and explains the importance of international trade for the Czech Republic. The following section provides information concerning Czech export policy and the institutions founded in order to support Czech export. The next part gives detailed description of CzechTrade agency, its development and provided services. The subsequent two chapters are focused on the description of Brazilian and Mexican markets, involving characteristics of both countries and their economies, as well as their economic relations with the Czech Republic. These two chapters also cover the activities and development of CzechTrade foreign offices in Mexico and Brazil. The final part of the thesis highlights particular projects realized in cooperation with CzechTrade foreign offices and offers a prediction of future development of Brazilian and Mexican markets.
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Evaluation of PRO.MED.CS Praha, a.s. and Pliva Lachema, a.s. by solvency and bankruptcy models
Kazdová, Kateřina ; Schönfeld, Jaroslav (advisor) ; Smrčka, Luboš (referee)
This thesis deals with the explanatory power of solvency and bankruptcy models designed to determine the financial health of selected companies with their predictions for future development for several years ahead. Pliva Lachema, a.s., which went into liquidation in 2010, was chosen as a representative of a bankrupting business. A prosperous company is represented by PRO.MED.CS Praha a.s. Both are pharmaceutical companies focusing on manufacturing drugs and developing new medicines. The theoretical part deals with different ratios and predictive models, including their structure and methods of their evaluation. The practical part describes results of the indicators of financial ratio analysis and prediction models for the above-mentioned companies for the years 2004-2008. The aim of this study is to determine if chosen solvency and bankruptcy models have a good explanatory power on the current status of both companies and if bankruptcy models are able to predict the impending bankruptcy of the company Pliva Lachema, a.s.
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Social Situation of Households in the Czech Republic
Valterová, Veronika ; Bartošová, Jitka (advisor) ; Bína, Vladislav (referee)
This bachelor thesis deals with the social situation in the Czech Republic and compares it with the social situation in Slovakia. It gives factors that affect household incomes and expenses in both states. It follows the development of average wages before taxation and handle poverty in the Czech and Slovak Republics. It compares individual monetary incomes according to the type of household and monetary expenditures for individual items of the consumer basket in households divided according to the person at the head. It describes the prediction of development of the boundary of income poverty and the develpoment of the average gross monthly wage in the Czech and Slovak Republics.
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Freshwater wetlands as a biogeochemical archive: Temporal changes in climate and environmental records
Zemanová, Leona ; Novák, Martin (advisor) ; Mihaljevič, Martin (referee) ; Hojdová, Marie (referee)
Worldwide, peatlands cover an area of 4.106 km2 . Plant primary production dominated over organic matter decomposition and enabled organic matter to accumulate during the last 11 000 years. Peatlands represent a reservoir of atmospheric carbon and they are a useful scientific tool for reconstructions of historical atmospheric pollution. The first part of the thesis focuses on peatlands as a dynamic carbon reservoir under predicted climate change that would influence carbon cycling and emissions of greenhouse gases into the atmosphere. Three methodological approaches were used - a mesocosm laboratory incubation, a transplant experiment and in situ gas flux measurements. The laboratory incubation studied the response of peat samples from temperate (Velké Dářko, Czech Republic) and boreal (Stor Åmyran, Sweden) zone to a temperature increase, water table decrease and their combination. Today, the warmer site exhibits ~14 times higher CH4 production potential than the colder site (28 mg m-2 hr-1 at VD, and 2 mg m-2 hr-1 at SA). Both sites respond differently to temperature increases. Changes in methane production were up to 9 fold due to different temperatures. A gradual decrease of water table level from 2 to 14 cm below the peat surface had a much stronger effect, VD exhibited a decrease in methane...
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Cloning and characterisation of selected Class II formins
Stillerová, Lenka ; Cvrčková, Fatima (advisor) ; Rösel, Daniel (referee)
Formins are proteins involved in regulation and construction of actin filaments of eucaryotic organism. They parcipitate in regulating cytokinesis, polar tip growth, and thus participate in development of whole organisms. There are 2 classes of formins in Arabidopsis thaliana. Both classes include FH1 and FH2 domains (formin homology 1 a 2). Class I formins have N-terminal transmembrane domain, unlike class II formins. Some formins of class II have a N-terminal PTEN domain (Phosphatase and Tensin Homolog). Sequence analyses predicted membrane binding via phosphatase or C2 subdomain of PTEN. This thesis was focused on the formin AtFH14, specifically its PTEN domain. Based on predicted sequence, a DNA fragment encoding the PTEN domain was amplified, sequenced and cloned to destination vectors for YFP and EOS phusions. Marked protein was visualized by transient expression in Nicotiana benthamiana. Stably transformed Arabidopsis lines were prepared for stably expression of protein. The tagged protein was localized in cortical cytoplasm, cytoplasmatical strands, probably in nuclear membrane or perinuclear cytoplasm, as well as in peculiar "folicle-like" structures that might be due to binding of PTEN at the periphery of some membrane organelles. Also were seen filament structures, maybe caused by PTEN binding...
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Fluorescence studies of bacterial membrane proteins and cell signalling.
Fišer, Radovan ; Konopásek, Ivo (advisor) ; Hof, Martin (referee) ; Forstová, Jitka (referee)
(English) This work is based on five publications studying mostly adenylate cyclase toxin (CyaA) from Bordetella pertussis and its interaction with biological membranes. CyaA permeabilizes cell membranes by forming small cationselective pores and subverts cellular signaling by delivering an adenylate cyclase (AC) enzyme that converts ATP to cAMP into host cells. First study clarifies the membrane disruption mechanisms of CyaA and another bacterial RTX toxin; αhemolysin (HlyA) from Escherichia coli. For this purpose, we employed a fluorescence requenching method using liposomes as target membranes. We showed that both toxins induced a graded leakage of liposome content with different ion selectivities (Fišer a Konopásek 2009). Both AC delivery and pore formation were previously shown to involve a predicted amphipathic αhelix(502522). In the second publication we investigated another predicted transmembrane αhelix(565591) that comprises a Glu(570) and Glu(581) pair. We examined the roles of these glutamates in the activity of CyaA, mostly on planar lipid membranes end erythrocytes. Negative charge at position 570, but not at position 581, was found to be essential for cation selectivity of the pore, suggesting a role of Glu(570) in...
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The value of neurohormonal activation assessment for treatment monitoring in congestive heart failure
Kubánek, Miloš ; Málek, Ivan (advisor) ; Špinarová, Lenka (referee) ; Pudil, Radek (referee)
Summary: Congestive heart failure (CHF) is associated with neurohormonal activation (NHA) which contributes to further progression of disease. Measurement of NHA has been used for diagnosis and prognostic stratification in CHF. Aims: The aim of this academic disertation was to analyze the value of NHA for treatment monitoring in CHF. We studied the relationship between NHA and pulmonary hypertension in compensated CHF using B-type natriuretic peptide (BNP) and big endothelin-1 (big ET-1). The rationale was to minimize repeated right heart catheterizations in candidates for orthotopic heart transplantation. A similar design had the second clinical study which used N-terminal pro-B- type natriuretic peptide (NT-proBNP) as a marker of NHA. In the third clinical study, we evaluated whether basal levels and/or change in NHA during treatment predict clinical efficacy of cardiac resynchronization therapy (CRT). We supposed that BNP and big ET-1 might be better predictors of outcome than standard methods of follow-up. Results: 1. Natriuretic peptides correlated with hemodynamic parameters better than big ET-1. An isolated measurement of BNP or NT-proBNP did not allow a reliable assessment of pulmonary hypertension or left ventricular filling pressure, respectively. On the other hand, serial evaluation of...
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Effect of colorectal cancer screening programs on lethality and incidence from this disease in the Czech Republic modeled by an APC approach
Čady, Ondřej ; Hulíková Tesárková, Klára (advisor) ; Kurtinová, Olga (referee)
This work will first introduce the problems related to the colorectal cancer - its epidemiology and screening possibilities. Next the main topic is addressed - i.e. to ascertain the influence of national screening programmes for colorectal cancer on really observed data of lethality and incidence of this disease. Group of so-called APC models was selected as a useful tool for this purpose. Applying these methods on data of The National Oncological Registry of the Czech Republic for the period between 1980 till 2009 this work aims to prove expected reducing effect of area-wide screening programme on incidence and lethality related to colorectal cancer. Using the AP model and data of previous period before the screening introduction (i.e. 1980-1999) the values of incidence and lethality were predicted for the period in question (i.e. 2000-2009). Mere comparison of this predicted values with really observed data showed that real lethality and incidence was significantly lower in both sexes as compared to the model without the screening intervention. Difference between predicted and real data corroborates positive influence of colorectal cancer screening.
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The economic comparison of China and India
Bestová, Adéla ; Kašpar, Václav (advisor) ; Vošta, Milan (referee)
China and India are the members of the group BRIC, which is a union of countries with a huge economic potential. The main aim of this thesis is the comparison of both the economies including future predictions. The first part is focused on the countries' historic development and its impact on contemporary business relations. The second part is dedicated to the comparison of these countries from the demographic point of view and their social situation. The last two parts analyse the balance of payments and foreign direct investments, particularly their trends, territorial and commodity structures.
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