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Assessment Center - Group Exercises
Mikesková, Martina ; Wagnerová, Irena (advisor) ; Michalík, David (referee)
The subject of my final thesis is the assessment centre as a method being used in practice of personnel psychology. The theoretical part is aimed at basic methods of assessment centre, it contains the definitions and instructions which limit and edit the assessment centre as regards its content and implementation aspects. It describes the processes of assessment centre creation and choice of its partial methods (dialogue, test methods, model situation etc). In more detail it deals with character of assessment centre partial methods and possibilities of their diagnostic outputs application. In particular chapter special attention is given to model situations and group exercises questions. At the same time it describes the assessment centre social-psychological aspects and its cultural and intercultural extent. The empirical part contains the description and analysis of particular existing assessment centre, from which a suggestion for its optimalization arises. Key words assessment center group exercises simulations
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Development of extraction and HPLC determination of vitamins A and D in pharmaceutical formulation Infadolan
Košvancová, Tereza ; Sklenářová, Hana (advisor) ; Matysová, Ludmila (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Title of graduation theses: Development of extraction and HPLC determination of vitamins A and D in pharmaceutical formulation Infadolan Tereza Košvancová Supervisor : PharmDr. Hana Sklenářová, Ph.D. The High Performance Liquid Chromatography conditions for the determination of vitamins A and D in ointment Infadolan® were found. The analytical column Onyx Monolithic C18 (50 x 4,6 mm) with guard column (5 x 4,6 mm) was used for achievement of optimal results. A mobile phase composed of acetonitrile : methanol : water in ratio 49 : 49 : 2 (v/v/v), the flow-rate 2 ml/min, the sample volume 20 µl, the isocratic mode and laboratory temperature were chosen. The UV detection was set at 265 and 290 nm. Vitamin E acetate was used as an internal standard. Substance were eluted in the following order: vitamin A acetate, vitamin D and vitamin E acetate. During the search for suitable extraction agents for the development of an extraction method the ability of many basic analytical solvents was tested. Agents with the most suitable properties were used in five multi-stage extractions. Achieved results were compared and next procedure was proposed.
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Non-parametric estimation of parameters of extreme value distribution
Blachut, Vít ; Popela, Pavel (referee) ; Michálek, Jaroslav (advisor)
The concern of this diploma thesis is extreme value distributions. The first part formulates and proves the limit theorem for distribution of maximum. Further there are described basic properties of class of extreme value distributions. The key role of this thesis is on non-parametric estimations of extreme value index. Primarily, Hill and moment estimator are derived, for which is, based on the results of mathematical analysis, suggested an alternative choice of optimal sample fraction using a bootstrap based method. The estimators of extreme value index are compared based on simulations from proper chosen distributions, being close to distribution of given rain-fall data series. This time series is recommended a suitable estimator and suggested choice of optimal sample fraction, which belongs to the most difficult task in the area of extreme value theory.
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Development of GC Metod for the Determination of Vitamine E Acetate in Nutritive Supplements
Kymlová, Helena ; Šatínský, Dalibor (advisor) ; Chocholoušová Havlíková, Lucie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Mgr. Helena Kymlová Consultant: Doc. RNDr. Dalibor Šatínský, PhD. Title of Thesis: Development of GC metod for the determination of vitamine E acetate in nutritive supplements A GC method was developed for the determination of content of vitamine E acetate in nutritive supplements. The method was optimised and validated. The column Capillary GC, Equity Columns, Equity TM - 5 poly (5 % bifenyl / 95 % dimethylpolysiloxan); 0,32 mm ID x 30 m; 1,0 mm dr was used for the analysis. Helium was used as a carrier. Split was 1 : 100. Flame-ionization detector was used for detection. Optimal conditions for analysis: temperature of column 340 řC, temperature of injection 340 řC, temperature of detector 320 řC, flow-rate 2 ml/min. Fenoxycarb was chosen as an internal standard. The method was used for an analysis of vitamine E acetate in nutritive supplements Geladrink Forte pulverized drink - pineapple and Chondrotin MSM 2600. Determined concentration of vitamine E acetate was re-counted to the content of vitamine E declared by producer.
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Implementaion of the controllers of a mobile walking robot
Krajíček, Lukáš ; Věchet, Stanislav (referee) ; Ondroušek, Vít (advisor)
This diploma thesis deals with design and implementation of the controllers of a mobile walking robot. The advantage of these controllers are their kinematics and geometrics independent representation, which allow to use them for different robot types and tasks. In this thesis the contact controller is designed, which minimizes residual forces and torques at the robot's center of gravity, and thereby stabilize robot's body. Next the thesis deals with a posture controller, which maximizes a heuristic posture measure to optimize posture of robot body. Because of this optimization, legs are moved away from their limits and therefore they have more working space for next move. Implementation of the chosen solution is made on the robot's MATLAB mathematical model. Controllers are composed into a control basis, that allows to solve general control tasks by simultaneous combination of contained controllers. The algorithm was created for that simultaneous activation and its operation was explained on flow charts.
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Optimalizace parametrů úlohy s rázovým zatížením v programu LS-DYNA
ŠTANGL, Jiří
Master's thesis focuses on numerical modeling of automotive tasks. The text is divided into two main parts. A fuel supply module is the main topic of all numeric analyses of this thesis and it is introduced in the first part. Basics of theoretical continuum mechanics and finite elements method are also explained in the first part. The second part is split into two main topics of the fuel supply module - material damping and contact numerical modeling. Practical reasons for parameter optimization are explained along with particular optimization results and underlying theoretical background.
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Mass Spectrometry Imaging of Metformin in Tissue Sections
Strnad, Štěpán ; Sýkora, D. ; Vrkoslav, Vladimír ; Cvačka, Josef ; Maletínská, Lenka ; Pirník, Zdenko
Mass spectrometry imaging is a powerful technique suitable for visualization of the distribution of a wide variety of compounds within tissue sections. The main aim of the study was the development and optimization of a sample preparation procedure allowing determination of the distribution of orally dosed metformin in mice kidney sections. Metformin is the first-line medication for the treatment of type 2 diabetes. The optimization of the sample preparation step before imaging experiments included the selection of a suitable matrix and the optimization of various parameters of MALDI analysis. 2,5-dihydroxybenzoic acid was identified as the best matrix providing highest sensitivity. A sublimation method was successfully used for the matrix deposition. The highest relative concentration of metformin was found in the inner zone of kidney 30 minutes after the drug administration.
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The real use of operations research methods in conjunction with logistics technologies
Fesenko, Anastasiya ; Kuncová, Martina (advisor) ; Pelikán, Jan (referee)
This diploma focuses on the real use of operations research methods in conjunction with logistics technologies. The aim is to show the way of optimization and simulation methods application and to evaluate if these methods are suitable tools for logistics technology application. Following logistic technologies were analysed: Just in Time, Kanban, Cross-Docking and Hub and Spoke. Used mathematical tools include: mixed linear programming models, distribution models, methods of multi-criteria evaluation and simulation models. On the basis of mathematical models 4 examples of new technologies introduction or analysis of already functioning systems have been solved.
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The Effectivity Analysis of BI using Oracle database
Řeháček, Tomáš ; Pour, Jan (advisor) ; Kovář, Štěpán (referee)
The main goal of this diploma thesis is to provide advice and recommendations to increase the effectiveness of Business Intelligence using Oracle database. More specifically, the focus of the thesis is the optimization of ETL processes and objects in a data warehouse. Tests to compare different optimization techniques are performed to meet the defined goal. These tests are based on common tasks solved in data warehouses on daily basis. Tests are also supported by publications of leading authors in Oracle environment. The second goal of this work is the implementation of appropriate optimization techniques to real ETL pro-cess in order to increase its effectiveness. Performance changes are compared and measured using metrics defined for the ETL process and requirements from client. Optimization techniques presented for main objectives are used to achieve the second objective. Contri-bution of the thesis is to show the most important optimization techniques and tips that every developer should know and be able to use effectively. Another added value is au-thor's practical experiences in real data warehouse environment.
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