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Ego mechanism of defense in alcohol-dependent patients
Červená, Helena ; Niederlová, Markéta (referee) ; Šípek, Jiří (advisor)
The objective of this dissertation was to examine the Ego defense mechanisms and defense styles in alcohol-dependent patients. First, we introduced the phenomenon of Ego mechanisms of defense, presented the brief history resumption, outlined the major topics of clinical research interest and described the possibilities of use of defense mechanisms analysis in a clinical practice, particularly in diagnostics and psychotherapy. The Oefense Style Questionnaire (OSQ 40) was used to examine a sample of subjects (n=60) with an alcohol-dependence diagnosis. Bivariate correlation analyses yielded these results: the alcohol-dependence in women was correlated with mechanisms Idealization, Projection, Oevaluation and Isolation of affect, whereas in men with mechanisms Suppression and Isolation of affect. There was no relation between this syndrome and certain defense style approved. These results confirmed the psychogonical etiology of the above problem in women and suggest the connections with neurotic, depressive disorder, borderline and narcissistic personality disorder. In men, the possible connection between the mechanisms Isolation of affect and antisocial personality disorder is expected.
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Instrumental gait analysis in the ACL patient
Lalaeva, Anna ; Dudová, Agnieszka (advisor) ; Lopot, František (referee)
Title: Instrumental Gait Analysis in the ACL Patient Aim: to present an up to date review on the topic of instrumental analysis of straight ahead gait on a plain surface (both over-ground and on a treadmill) in ACL patients (both deficient and reconstructed). A second aim is to introduce the clinician (especially in the field of physiotherapy/rehabilitation) to the topic of gait analysis and its specific use for the ACL patient. Methods: a systematic review on the topic Results The review answers the questions of what instrumentation, phases of gait and variables is best to use/measure for clinical purposes. It also identifies and discusses three main gait strategies used by ACL patients: quadriceps avoidance, knee stiffening, pivot shift avoidance. Keywords: gait, analysis, walking, clinical, instrumental, anterior cruciate ligament, ACL, deficient, reconstruction, injury
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Implementation of leasing solution into ERP Microsoft Dynamics Navision
Juřík, Vlastimil ; Smutný, Zdeněk (advisor) ; Říhová, Zora (referee)
This master's thesis delivers a comprehensive view at leasing business processes running in small and medium-sized leasing companies including the feasibility of their support through an imple-mentation of leasing application software. The first objective of this thesis is the design of an application software system, which will cover general leasing process in small and medium-sized leasing companies for the purpose of development packaged application software system suitable for implementation into small and medium-sized leasing companies. The second objective is a design of a specific implementation of a software system defined in previous objective of thesis. The design of an implementation is based on Microsoft Dynamics Sure Step project management methodology, which was adapted for the purpose of implementation of designed leasing application software into medium-sized leasing company. The first part of the thesis introduces basic concepts occurring throughout whole thesis for a clear understanding of the purpose of the practical work and its processing. The second part describes the Microsoft Dynamics platform as a variety of business software tools suitable for departmental development of leasing solution. This platform includes project management methodology suitable for the business software tools. The third part contains a design of an application software covering general leasing process. The fourth part describes the design of a specific implementation of a leasing application software system defined in previous part of thesis into medium-sized leasing company.
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The significance of the principle of publicity in criminal proceedings
Závodský, Ondřej ; Musil, Jan (advisor) ; Herczeg, Jiří (referee) ; Púry, František (referee)
Dissertation thesis titled "Significance of principle of public in criminal trial" deals with the principle of public in criminal procedure in the widest sense of the word. The thesis explains what is meant by this principle, what its functions are or what the consequences of its non-compliance by authorities acting in criminal procedure can be found. By the fact that this work mentions also the aspects of informing the public about criminal procedure as well as about possibilities of defence in case of non-compliance of mentioned principle by authorities acting in criminal procedure, it also interferes, besides criminal substantive and procedural law, in constitutional, press or protection of personality laws. The text of dissertation thesis is divided into nine chapters. In the introduction part the area of topics mentioned in following chapters is defined. In chapter titled "History of literature connected to the topic" there are important publications, articles from academic periodicals, as well as graduate theses which in the past somehow affected the chosen topic, mentioned. The third chapter summarizes development of legislation about publicity of criminal trial as well as some of the related aspects, from the beginning of the Czech statehood till present. Beginning with the fourth chapter...
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Periprosthetic osteolysis
Veigl, David ; Vavřík, Pavel (advisor) ; Vencovský, Jiří (referee) ; Koudela, Karel (referee)
Periprosthetic osteolysis remains the leading complication of total hip arthroplasty. It often results in aseptic loosening of the implant with a requirement for a revision surgery. Wear-generated particular debris is the main cause of initiating this destructive process. The most important cellular target for wear debris is a macrophage, which responds to particle challenge by activatig proinflamatory signals, which contribute to increased bone resorption. The activation of the RANKL/RANK/OPG system is considered to be a likely cause of periprosthetic osteolysis leading to implant failure. The aim of this study was to examine the possible correlation between the clinical extent of osteolysis, the number of wear particles and the expression of the osteoclastic mediator RANKL in the tissues around aseptically loosened cemented and non-cemened total hip replacements. Periprosthetic tissues were harvested from 59 patients undergoing revision hip replacement for aseptic loosening. We had observed RANKL-positive cells in 23 of our 59 patients, their presence was noted predominantly in tissues with a loosened cemented endoprosthesis. We have shown that RANKL is present only in the tissues with a large amount of wear debris and predominantly in the cases involving lacunar type of osteolysis. Key words:...
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Using the IGRT and IMRT methods to treat prostate gland carcinoma and their side effects
KŘIVSKÁ, Klára
Prostatic carcinoma is a disease with a continuously increasing number of newly diagnosed cases all over the world. According to the commonly available statistic data it is the most frequent tumour disease of men. As far as oncological causes of death are concerned, it occupies the second place, after lung cancer. The situation in the Czech Republic corresponds to this trend. The incidence in this country has almost tripled in the last two decades. On the other hand, the number of deaths due to prostatic carcinoma decreases and it is approximately one third lower now. This very significant difference is given especially by the possibility of examination for the prostate-specific antigen (PSA) within the framework of preventive medical check-ups at general practitioners or at other specialists. The modern treatment of prostatic carcinoma, whether it concerns radical (curative) treatment or support (palliative) treatment, also has had an indisputable positive effect. According to the data obtained from the statistics managed by the National Cancer Registry from 2009, the number of newly diagnosed prostatic carcinomas in the Czech Republic reached 119.3 cases per 100,000 men. The death rate was 28.5 cases per 100,000 men. In conversion to absolute numbers from 2009 it means that 6154 men were diagnosed with a prostatic carcinoma and 1472 men died of it. Great success of modern treatment is confirmed also by a percentage expression of survival of patients after the end of treatment. In the time period of the last thirty years, the overall five-year survival for men with a prostatic carcinoma has increased from 68% to the current almost 100%. This means that an overwhelming majority of patients still live after five years from the diagnosis of their disease. Treatment of prostatic carcinoma has included the conform radiotherapy since the time of its introduction. The pioneers of this therapy are Japanese scientists Umegaki and Takahashi, who invented, in the 1960s, the first rotational conform radiation technology. It is more often associated with introduction of computer tomography (CT) into ordinary clinical practice. It was only in 1983 when a 3D planning system was presented, which then facilitated further development of tumour-conform radiotherapy. It was established that the doses from conventional techniques (e.g. a box) are not sufficient for the patients, do not lead to recovery and, quite on the contrary, they even increase the risk and major development of side effects. The advanced method of intensity-modulated radiation therapy (IMRT), which started to be applied in practice in the 1990s, achieved much better results. Besides a change in the beam shape it enables a change in the beam intensity as well. This can be achieved in cooperation with a multi-leaf collimator (MLC) which changes the shape of its lamellas dynamically and thus it modifies and transfers its beam. Method IMRT better and more accurately shaped beam and thereby more saving to surrounding healthy tissue
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Study of the microRNAs in patients with head and neck squamous cell carcinoma
Hudcová, Kristýna ; Šulc, Miroslav (referee)
Searching for markers of disease is at the forefront of scientific interest. Biomarker of a specific disease should help in disease management - whether for diagnosing a disease or predicting its progress. We picked microRNAs - short RNAs that regulate mRNA translation, due to their stability and function in the regulation of many cellular processes. Therefore they can be used as a biomarker for many diseases. In our study we focused on neck squamous cell carcinoma (HNSCC), since this type of cancer is widespread and clinically important markers are missing. It is in our interest to seek new kinds of markers, suitable for early diagnosis of the disease and the most accurate assessment of prognosis. We selected 3 candidate miRNA (miR-29c-3p, miR-200b-5p, miR-375-3p) and used qRT-PCR method to profile their expression in tissues of patients with HNSCC. MiRNA expressions in 42 tumor samples were compared with the miRNA expression in adjacent tissue of the tumor. Adjacent tissue surrounds the tumor and has interesting properties, as it looks like a histological normal tissue, but on closer inspection it is not. It is affected by tumor tissue and may contribute to tumor progression. We managed to distinguish between these two tissues using miR-29c-3p and miR-375-3p. Additional analyzes were focused on...
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Concept of Government Enterprise Architecture for Czech Public Administration
Hrabě, Pavel ; Basl, Josef (advisor) ; Skrbek, Jan (referee) ; Čapek, Jan (referee)
The subject of the dissertation is exploring the use of enterprise architecture as a managerial method to support the transformation (reform) of Czech public administration. The dissertation shows that enterprise architecture is in the public sector of Czech Republic still not used, even though public sector organizations want to continue improving its services and management in a way where enterprise architecture could be beneficial. The thesis aims to understand the needs of public authorities towards the possibilities and benefits of enterprise architecture and propose such a customization that could increase the adoption and use of enterprise architecture by these organizations. The main objective of thesis is to summarize individual partial results of author's research into the design of overall Concept of the structure and procedure of implementation of National Public Administration Architecture of Czech Republic. Research within the dissertation combines two basic research methods. Both represent qualitative research methods, suitable for the development of new methods and artefacts (Design Science Research) and for proof the hypotheses and outputs (Case Studies). To create preconditions of the proposed concept was necessary to verify the status of the Czech public administration from the perspective of current rate, needs and interest for the use of enterprise architecture to support the reform of public administration. To verify the status of environment and the needs served basic research questions, further elaborated into detailed questions of multiple case study. In the analytical part of the thesis are summarized significant findings the analysis of information resources and literature in the areas of a) the definition of enterprise architecture, its position, role and development trends for design changes in the structure and metamodel of TOGAF framework, b) the existence of available models and key design principles of application architecture reference model and c) experience of the implementation and use of enterprise architecture for public administration reform. The main part of the thesis focuses on the proposals in three areas. In the first part are designed theoretical and practical changes in the definition, structure and metamodel of enterprise architecture to better support its application for real reform of public administration, not only to improve the management of IT. Presented proposals are in the same time providing solutions to some identified discrepancies in the trends of development of enterprise architecture. General proposals are in parallel applied as changes in the standard TOGAF, which is then recommended as the initial framework for the National Public Administration Architecture of the Czech Republic. In the second part of the proposals are presented principles and content of the reference model of application architecture. This is an example the accelerator necessary to solve the discrepancy between the scope of enterprise architecture and its feasibility with limited resources. The thesis emphasize the industry adjusted model for public administration and its application in a hierarchical, fractal environments typical of public administration. In the third part are presented key components of the overall concept, using as well as previous research results of this thesis. As the key elements are presented proposal for the structure of National Public Administration Architecture of the Czech Republic environment, proposal for the procedure of implementation of National Architecture and the proposal of products (outputs) for deploying National Architecture in Czech Republic. Additionally are formulated proposals of ways of using National Architecture in Czech public administration and conditions and prerequisites for introduction of National Architecture in the Czech public administration.
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Management of gray water and rain water
Kocourková, Michaela ; Synáčková, Marcela (advisor) ; Renata, Renata (referee)
Evolution and advancements of human activity is unstoppable, still we should not forget about basic natural processes which proceed no matter how man can influence them. Water is one of the main constructors of life and is necessary for function of everything live on the planet Earth. It often is categorized among the inexhaustible resources, still there lacks enough drinkable water. It is consumption grows in recent years with fast development of cities.
It is the most important part of life on Earth and with urbanization and anthropogenic interference water is negatively affected and thus it is processes in nature. Interfering with water cycle makes for higher occurrences of droughts and floods, the quality of water streams suffers. Urban areas lack the surface where water could soak into the subsoil and underground water resources shrink. Through all these influences with which we affect natural water cycles the need for water and its consumption grows in our societies. For effective use of water comes up the idea of using not only the drinkable water but waste water and other types as well. Sources can be various, rain water, reused water.
The focal point of this thesis is to be the impetus of discussion concerning the use of rain water and directly cleaning and reusing the water which comes straight from our homes. Rain water fills up underground water resources and also could be used in place of potable water. Substituting the potable water in activities and industries where such a high quality water is not needed and could be easily replaced with grey water. Grey water, being the waste water that comes from our bathrooms, is easily cleaned and can be used for various necessities. Current state where the potable water is used in absolute majority of human life appears to be extremely wasteful and unecological. Use of grey water and rain water is a possibility of ecological and thrifty water management which could prevent environmental damages and save water resources for the next generations.
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Measurement of the fiber optical transport links
Ambrož, Jan ; Škorpil, Vladislav (referee) ; Reichert, Pavel (advisor)
This thesis deals with the measurement of optical transport links. In particular, the measurement of attenuation, chromatic and polarization mode dispersion. Specic me- asurement systems using a WDM and passive optical networks. Within each chapter are listed the causes and eects restrictive factors and methods of measurement. In chapter Attenuation measurements are described radiation and material loss as the main causes of depression. Methods whitch are described two lengths, insert loss and reectometri. Chromatic dispersion at dierent speeds of various wavelengths limits systems with high transfer rate. Methods of measuring the phase shift, dierential phase shift, pulse time delay and interference. Polarization mode dispersion is a random phenomenon caused double refraction, must be measured after completion of the route. Scanning wavelen- gth, traditional and general interference, reectometri and the polarimetric are methods of measurement. It described the measurement of WDM systems in three stages of its build. In brief PON networks are presented, with the specicities of the measurement over splitter. Most chapters are supplemented by the results and conclusions of practical measurements. At the end of the work are given by the two standards deal with the measurement of optical transport links.
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