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Nanofiber membranes as carriers of drugs 2. Polyvinylalcohol, chitosan, (D,L) polylactic acid.
Bidmonová, Hana ; Doležal, Pavel (advisor) ; Dittrich, Milan (referee)
1. ABSTRACT Diploma thesis concerns with the evaluation of the basic properties of the nanofibre membranes that are made of polyvinylalcohol, chitosan and (D,L) polylactic acid in connection with their possible use as carriers of drugs. Thesis characterizes electrospinning as a method of production of nonwoven textiles and nanofibre materials, polymers that were used in preparation of the nanofibre membranes under experiments, and testing methods that were used. Transdermal pharmaceuticals declared in the AISLP database were summarized in the connection with their possible use in drug administration. The selected physical characteristics of three chemical types of the nonwoven nanofibre membranes made in laboratories ELMARCO Liberec were investigated. The tensile stress properties, hydrophile-lipophile character of surface and absorption-release properties of the membranes were studied at a permeation in vitro study using caffein as a model drug in the experimental part of my work. Tensile properties of membranes are affected by previous radiation sterilization and direction of testing. General characterization of all membranes was not found. Chitosan membrane becomes firmer material after sterilization and it is also tougher in transverse tensile force. PLA membrane is weak after sterilization and also...
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Adoption at a distance of zambian´s children
ŠAREŠOVÁ, Veronika
My diploma thesis is dealing with extended Adoption at distance of Zambian children and had research character. Thesis is divided into two parts; first one is theoretical, second is practical. Theoretical part consists from nine chapters. Continuously they describe history and actual state of Zambia, individual development especially in relation with education, focus and objectives of UNICEF activities, OSN and international documents dealing with human rights, education and its value in humans live, educational system in Zambia and its structure, extended adoption, organization that are realizing extended adoptions in Zambia and the last chapter is mentioning more organizations, that are realizing this project.The practical part of the thesis has scientific character. The objective of the thesis is to describe the project of extended adoption and the relation of Czech society to this project. In order of this aim three hypothesis have been made. In the first one I assume, that Czech society think that extended adoption is beneficial, but does not believe that the financial assets are not spend on the right purposes. In the second hypothesis I assume, that there is no discrimination in choosing the children taking part in the extended adoption programme based on tribe nationality, race or religion. The last hypothesis assumes that Zambian children are interested in education and that why they think the project is good for their future lives.For approving or declining hypothesis I used the method of questionnaire and discussion. The questionnaires were given to Zambian children and Czech public society. The discussion was realized with employees of certain organizations that are realizing the project of extended adoption programme. Altogether there were 170 questionnaires, 100% of them were returned.The hypothesis are analysed at the end of practical part. In the end there is summary of certain pieces of knowledge from theoretical and practical part. The last part of this diploma thesis contains the appendixes.
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Architectural Transformations of the Chateau of Hrubý Rohozec
Lyčková, Barbora ; Nespěšná Hamsíková, Magdaléna (advisor) ; Šmied, Miroslav (referee)
While concentrating on the comparison of conclusions regarding the chateau of Hrubý Rohozec in published academic work, this paper also presents an overview and evaluation of the architectural transformations of said chateau. The time period addressed spans four centuries, commencing with the building of the chateau and ending in the 17th century. Emphasis is placed on the early-medieval phase of the chateau, on the building activity which took place in the late Gothic era (Krajířové z Krajku), and on the later Renaissance alterations of Hrubý Rohozec by the Wartembergs (z Vartemberka).
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The role of history in nation-centred social scientists texts from the end of the 19th and beginning of the 20th century: Masaryk, Unamuno, Dmowski, Gökalp
Scholz, Milan ; Řezník, Miloš (referee) ; Klusáková, Luďa (advisor)
The thesis deals with the comparative analysis of the role of history in four nation - centred works from the end of the 19th and the beginning of the 20th century. The complex of analyzed works includes three texts of T. G. Masaryk concerning the so called 'Czech question' - Česká otázka [Czech Question], Naše nynější krize [Our Contemporary Crisis], Jan Hus [Jan Hus], Unamuno's book En torno al casticismo, Dmowski's Myśli nowoczesnego Polaka [Thoughts of Modern Pole] and Gökalp's Türkçülüün esaslar [The Foundations of Turkism]. The structural and thematic similarity was the main criterion for the choice of these texts. All texts deal with the problem of 'national existence', combine the features of works in social sciences with the ideological element and use history and historical examples for the construction of national programme. The thesis looks for the similarities and differences in the use of history and in the role of history in constructing national programmes in the analysed texts, and tries to define their typology. Furthermore the treatise examines the relation between the degree of modernization and the political position of respective society (dominant, non - dominant) on one hand and the way of using historical examples on the other. The thesis is divided in five chapters. The first...
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Semantic and pragmatic aspects of the prosodic component of the message in simultaneous interpretation
Marešová, Julie ; Sládková, Miroslava (referee) ; Čeňková, Ivana (advisor)
Julie Marešová, Semantic and Pragmatic Aspects of the Prosodic Component of the Message in Simultaneous Interpreting, Institute of Translation Studies, Faculty of Arts and Philosophy, Charles University, Prague, 2009 The thesis focuses on the prosodic component of the message in SI from the point of view of the speech listener, the interpreter and the interpretation listener. First we described the general function of prosody and its role in SI. We mentioned Gile's Effort model which is closely related to the prosody of source speech. We also considered the interpretation quality assessment from the point of view of the final client. The empirical part is focused on the way the prosodic character of the source speech influences the interpreter's work and whether the same influence can be seen in the client's assessment of the interpretation. Using computer analysis (computer programme PRAAT) and retrospective questionnaires we have found out that the interpreters are completely aware of the source speech prosody. If the prosody is unnatural or inadequate it raises the demands on concentration and understanding and makes interpretation more difficult. We did not confirm the hypothesis that source speech prosody is reflected during SI in the same way. There was a large diversity in the assessments by the...
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Art group 12/15 Better Late than Never
Jungová, Markéta ; Potůčková, Alena (referee) ; Lahoda, Vojtěch (advisor)
The free art group called "12/15 Pozdě, ale přece" was founded on the 3th of June 1987 in Václav Bláha's studio. However, the beginnings of collective activities of its members are to be found already in the first half of the 70's when these artists started to exhibit their art together. During those beginnings and through all the time of normalization, too, they found their place in exhibition rooms of the alternative (unofficial) culture. Hence, they had no chance to present themselves adequately enough. Besides their close friendship, it was one of the reasons of establishing an art group. The members of 12/15 were not unified by any collective art program. It was a group of individuals freely creating and thinking. Its founding members were: Václav Bláha, Vladimír Novák, Petr Pavlík, Michael Rittstein, Ivan Kafka, Ivan Ouhel, Jiří Beránek, Kurt Gebauer, Jaroslav Dvořák and Tomáš Švéda. Since their second exhibition (1988) Jiří Načeradský become a new member, and since the third one (1990) Jiří Sopko. Gradually this circle has expanded by joining a cultural worker Jiří Halík, and a group manager Josef Vomáčka. During the years 1988-1996 they organized 7 collective exhibitions. To each of them some propagation materials were created: posters, flags, invitation cards and so on; an author of their graphical...
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Gothic mural painting in castle chapels in Bohemia
Čechová, Lucie ; Royt, Jan (referee) ; Hlaváčková, Jana Hana (advisor)
This work is an investigation of Czech Gothic murals in castle chapels in Bohemia. The key for including of a mural to the catalogue was the founding date between early middle-ages up to the year 1526; end of the hegemony of the Jagellon dynasty amongst Bohemian Kingdom. The core of the work is a comprehensive catalogue of such murals. Included are 12 localities where these murals can be found, dating through 300 years of the middle-ages. Not included in this catalogue are the three well-documented sacral spaces in Karlštejn castle, although they also fit the time period in question. It must be acknowledged that the Karlštejn chapel murals are key elements in understanding this style and era, due to their quality and influential nature. This essay sought to isolate and explore any specific typology in this class of artwork. However, it must be stated that no such unique common character exists. The murals are more a reflection of the requirements and tastes of the individual patrons; they also express the fashion of their particular eras. There are also discrepancies in quality, which vary from century to century. In the 14th century, the quality of the investigated murals cannot be compared to that of paintings in the court of the King. However, by the late 15th and 16th centuries, the quality of murals...
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Analysis of children's playing with their mother and father
Plešková, Lucie ; Šulová, Lenka (advisor) ; Horáková Hoskovcová, Simona (referee)
This rigorous thesis goes from my diploma thesis and its a part of the grant task n.406/01/220 of the Grant agency of the Czech republic. The grant task is focused on the specifics of early interactions of young child with the members of their family. The solver of the grant task is Doc. PhDr. Lenka ulová, CSc. The theoretical part of the work is devided into five main chapters. The first one is focused on the role of mother in childs development. The second one is oriented to the role of father. In the third chapter is closely analyse childs play up to age of three. The fourth chapter is focused on the specifics of mother-infant play, the fifth one is dedicated to the specifics of father-infant play. The research presented in the empirical part consists in the analysis of recorded play interactions of 1,2 and 3 years old childern with their mothers and fathers, that were taken in their homes with the standardized set of toys. The results were analysed by the programme V.I.P. into several categories (look, vokalisation, smile, manipulation with toys, motorical activity, physical contact). There were observed differences between mother-infant and father-infant play with a view to the sex of the child too. The results are presented for each child separately, for 1,2 and 3 years old childern, for the whole...
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Endometriosis and its influence on woman's life
Varhanová, Dana ; Voleníková, Ivana (advisor) ; Feldmár, Peter (referee)
This work is about gynecological disease, whose incidence is evergrowing, end metriosis. Endometriosis is in itself a very controversial disease, which is sign ificant intervening into life of a woman. Endometriosis is a common gynecological di sorder affecting fertile female population. It is the disease, that is presented by functional endometrial glandules and stroma outside their usuallocality within uterus (womb). General symptoms are pain and infertility. The diagnostic key is the cyclic character of symptom s and laparoscopy - histology testification presence of lesions. Tbe surgical treatment of endometriosis is considered as a golden standard of the therapy. My aim of this work is to have look up to aH sections of the disease. At the same time my work covers survey. I detected prospective abnormalities with theoretic knowledges via fonns distributed to patients with endometriosis. The fonn appraised frequen y oť symptoms in patiens. It presents the most frequent age group of disabled women as well. Fonns a1so outline dilernma of arguments about character of creation and it observes problems of indisposed women and possibility oftheir naturally gravidity. It also deals of possibilities of available therapy and its use in patients. ln no little importance my work adverts to next facts des rving next...
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Private military companies: a geopolitical tool or a tool of private interest
Kofroň, Jan ; Bureš, Oldřich (referee) ; Tomeš, Jiří (advisor)
9 Abstract The industry of Private military companies has been one of the most progressive sectors within the frame of the global economy in the last years. The phenomenon is quite recent, when the roots of modern military companies range on the end of the 80's. The fall of the Bi-polar competing has opened a wide range of possibilities for military companies. The demise of over-numerated armies has created a skilled work force of former soldiers. On the other hand, conflicts and instability persisted in the world periphery. Early years of the market were connected with South African firm Executive Outcomes. However EO had became famous until its dissolution, massive concern of both scholars and politicians has come when Coalition forces entered Iraq in 2003. Wide range of activities has been offered to private sector: from logistic and maintenance, to guarding and personal protective services. There are 180 000 contractor in the country today. In the rough 20 000 to 30 00 of them should be described as "real soldiers" without uniform. Extension of private activities in Iraq and its consequences has led to the "publicity" of the problem. The problem has obtained wide attention from academics as well as decision makers. The goal of the submitted thesis lies in the exploration of PMC's ability to be an...
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