|
LABORARTORY BRNO
Lišková, Nela ; Šupler, Libor (referee) ; Jura, Pavel (advisor)
The building site is located in the heart of the Moravian metropolis - Brno. The corner site at the edge of a historical core is determining for the project, because of its importance for the city. The shape of the building closes the corner site and is flowingly connected with the build-up area on Koliště and Milady Horákové streets. The facade of the building is in compliance with the concept of the gallery - which is continuous open space. This space is filled with elements that fulfill the communication function and the operational function (provide the operation of the gallery).
|
|
název v anglickém jazyce není uveden
Křemen, Jaromír ; Haluzík, Martin (advisor) ; Stárka, Luboslav (referee) ; Zadák, Zdeněk (referee)
Insulin resistance is one of hot topics of present medicine not only in its braches focused on civilization diseases such as diabetology or obesitology but also in other fields, namely in intensive care medicine. Hyperglycemia caused by accelerated insulin resistance is observed in critically ill patients very often. It has many undesirable effects and potential complications. This phenomenon is caused by a network of different mechanisms, especially by systemic inflammatory response and subsequent burst of stress hormones and proinflammatory cytokines which directly participate in the ethiopatogenesis of insulin resistance. Recent investigations documented that many of proinflammatory cytokines are directly produced by adipose tissue. Although basic mechanisms of insulin resistance and type 2 type diabetes mellitus in obese subjects are somewhat different in both pathologie overproduction of some proinflammatory cytokines by adipose tissue may play a role. It has been demonstrated that correction of hyperglycemia in criticially ill patient by intensive insulin therapy leads to reduction of thein morbidity and mortality. Tight glycemic control requires a frequent blood glukose measueremnts increasing the workload of ICU personnel Therefore, the development of systems for continuous measuring of glycemia and...
|
|
The pharmacotherapy of epilepsy
Trávníčková, Jana ; Melicharová, Ludmila (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of pharmacology and toxicology Candidate: Jana Trávníčková Supervisor: PharmDr. Ludmila Melicharová Title of diploma thesis: Pharmacotherapy of epilepsy Epilepsy is one of the most frequent central nervous system diseases. This disorder is characterized by repetitious epileptic spasms. Classic as well as modern antiepileptic medication is being used in nowadays therapy with various effects, indications and adverse effects. Pharmacotherapy must always be continuous and long-term based, sometimes even long-life. In some cases surgery treatment may be used. An important part of epileptic treatment is non-pharmacological processes. Even though we cannot wholly cure epilepsy by pharmacotherapical methods, nowadays possibilities of epileptic treatment enable us to improve quality of life of a patient and help them live their life without major limitations.
|
|
Continuous vertical conveyor for transport the goods
Zálešák, Martin ; Bukovský, Radim (referee) ; Kašpárek, Jaroslav (advisor)
This diploma thesis deals with the existing of transportation unit products and designing of a better conceptual solution of continuous elevator with fixed section of a gravity and roller conveyor. This type of conveyor is specified mainly for the transport of boxed products from the lower floor to the another. The diploma thesis is substantiate by the proposal of assemblies machines. It includes a complete 3D design, engineering and functional solution that is supported by basic strength and the check calculations. The attachments consist of the drawings of the proposed facility.
|
|
Metabolic effects of chronic metformin administration in obese mice depending on the composition of high-fat diet
Roubalová, Jana ; Rossmeisl, Martin (advisor) ; Vybíral, Stanislav (referee)
Obesity leads to many severe metabolic disorders, e.g. dyslipidemia, insulin resistance, ectopic fat accumulation in the liver and skeletal muscles, non-alcoholic fatty liver disease and finally diabetes mellitus type 2. Metformin (1,1-dimethylbiguanide) is the most favored medicament for the treatment and prevention of these disorders. It stimulates cellular glucose uptake and normalizes blood levels of lipid metabolites without triggering insulin secretion. Research on insulin resistance and diabetes is often realized through developing diet- induced obesity in laboratory animals. The aim of this project is to compare metabolic effects of two different high-fat diets named HFD and HSD. The HFD diet consists chiefly of n-6 polyunsaturated fatty acids (corn oil) and starch (100% glucose). The HSD diet contains mainly saturated fatty acids (lard) and sucrose (50% glucose and 50% fructose). I also studied metabolic effects of metformin by adding it continuously to the drinking water given to obese mice fed with the HFD or the HSD diet. Methods: Intraperitoneal glucose tolerance test (IPGTT), blood and tissue levels of lipid metabolites assessment, radio-immunological assessment of blood levels of insulin, assessment of AMPK activity in liver by western blotting. Results: Increased consumption of the...
|
|
Continuos generating spur gear grinding
Jermolajev, Štěpán ; Osička, Karel (referee) ; Prokop, Jaroslav (advisor)
The diploma thesis deals with the technology of continuous generating gear grinding. With reference to this technology, used grinding wheels and grinding machines are described. A detailed analysis is devoted to the technological parameters of the grinding process and their influence on the resultant tooth flank surface integrity. In order to verify described rules, the diploma thesis contains results of practical experiments as well.
|
|
Equipment for Thickening Waste Water from Biogas Plants
Vondra, Marek ; Bébar, Ladislav (referee) ; Hoffman,, Pavel (referee) ; Stehlík, Petr (advisor)
This dissertation thesis deals with the development of technology which could tackle two major issues related to biogas plants. These issues concern the insufficient use of waste heat from biogas combustion and its subsequent processing. It also concerns the use of the fermentation residues which are formed in large quantities and whose use is restricted by law. Based on a literary search of separation methods, a vacuum evaporator was selected as the most suitable technology. Its advantages include its simple construction, operational reliability and robustness, low costs of thickening medium pre-treatment, potential for a quick commercial application and, especially, the chance to use a low-potential waste heat. A primary purpose of this technological unit is the reduction in the volume of fermentation residues. Other benefits include the efficient use of waste heat from a biogas plant, which would otherwise be wasted. Evaporators with a low consumption of electrical energy (which is a main product of a biogas plant) seem to be the best option for applications in the biogas plants. Three of these technologies were subjected to a more thorough analysis, which included the development of computational models and their quantification for conditions in a sample biogas plant. A one-stage evaporator with a forced circulation (680 – 712 kWhth/m3, 25.9 – 30.5 kWhel/m3) was evaluated as the least suitable option in terms of energy demands. The energy intensity of a three-stage evaporator with a falling film (241 – 319 kWhth/m3, 12.0 – 23.6 kWhel/m3) and a nine-stage flash evaporator (236 – 268 kWhth/m3, 13.6 – 18.4 kWhel/m3) is significantly lower. A multi-stage flash evaporator (MSF) was then chosen for development and will form the central focus of this thesis. The reasons for the choice are as follows: the low requirements on the heat transfer surface, good operational experience in the field of desalination, its simple construction, modularity and evaporation outside the heat transfer surface. A thorough technical-economic evaluation was also performed on the integration of the evaporator into the biogas plant. The main part of the work included the experimental development of a MSF evaporator prototype. The main objective of this development was to achieve a stable flow rate of the thickening liquid digestate fraction and the continuous formation of the distillate. This was not an easy objective to achieve, especially due to the properties of the liquid digestate, which has a non-newtonian characteristic and increased density and viscosity compared to water. The tendency of the liquid digestate to form foam was also the subject of analysis. The development of the evaporator and first successful operational test are described in the thesis in detail. This required the use of an anti-foaming product. A fully-developed prototype of the MSF evaporator allowed us to achieve continuous operation with a distillate production, reaching from 5 to 10 kg/h at a liquid digestate flow rate of 0.4–0.5 m3/h. The main drawback of this technology is the pollution of the distillate with ammonia nitrogen, and it is for this reason that the basic procedures of its subsequent elimination was selected for further analysis.
|
|
Continual helicoidal mixer
Pelka, Tomáš ; Malach, František (referee) ; Malášek, Jiří (advisor)
This diploma project works out and is focused on the continual mixing process of the particular matters. The project is divided into following chapters. Chapter 1 includes mixing theory and information of the experimental work of the particular matters for blade using. In chapter 2 there is Evaluation and calculation of the technical parameters for the mixer. Chapter 3 deals with the engine proposal and chapter 4 includes calculation and design work of the gear transmission. Chapter 5 includes the stress analysis of the shaft and blade with the I-deas software. In attachment there are also the mixer arrangement drawing and detailed drawings of the key parts and groups for the mixer.
|
|
Unconventional methods of welding of wrought magnesium alloys
Klimčáková, Kateřina ; Mrňa, Libor (referee) ; Doležal, Pavel (advisor)
Master's thesis deals with consideration possibility of conventional and unconvetional welding methods of wrought magnesium alloys. Methods of Friction Stir Welding, Pulsed Nd:YAG laser and Continuous Fiber laser was used to join magnesium alloy sheets AZ31, AZ61, ZE10 and ZE41. For studying influence of processing parameters on microstructure and mechanical properties were used methods of light microscopy, scanning electron microscopy, tensile tests and microhardness measurements. The results of tensile tests show that from the point of view of keeping ultimate tensile strength is the best methods for welding magnesium alloys Friction Stir Welding. Compared with Nd:YAG laser, fiber laser give better properties of welds. From comparing microstructure and mechanical properties . It wasn't found publications about Friction Stir Welding of magnesium ZE alloys or about FSW sheets with thickness only 0,8 mm and 1,6 mm.
|
|
Adaptation of northern pike (Esox lucius L.) on artificial pelleted feed under controlled conditions
HAJÍČEK, Jiří
The main objective of this thesis is to describe and experimentally evaluate the possibility of adaptation of pike (Esox lucius L.) in controlled housing conditions and income artificial pelleted feed. The thesis is mainly based on the effect of an initial larval density of pike for adaptation and survival and the growth of larvae reared in the rearing tanks. The experiment consisted of four different densities of larvae (10, 20, 40, 80 pc of the larvae l??, which were always repeated three times. Two experiments were performed (M, H), with a length of rearing of five days. Rearing itself was conducted in twelve circular tanks with a capacity of 180 l??, the recirculation system connected to the experimental rearing facility in Vodňany FROV JU. The temperature during rearing was constant. For the first experiment the temperature was 22.3 ? 03 °C. For the second one, the average temperature was 21.5 ? 0.6 °C. The frequency of feeding was continuous (24 h) with a combination of hand feeding and feeders with a timer (at night). The illumination of the aquarium tanks was provided by fluorescent lamps, for each tank individually. The light intensity was high (210 lux) and constant during the rearing. Both experiments showed the optimal density at the initial feeding from 20 to 40 units . l??. Also, we have implemented made out performed- the basic biometric analysis of W (g) and TL (mm), the body length, size of eyes, head, jaw length, prenatal length.
|
guest ::
