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Artificial Vocal Folds for Source Voice Generation
Vašek, Martin ; Vampola, Tomáš (referee) ; Kamenický, Ján (referee) ; Mišun, Vojtěch (advisor)
The first part of this work focuses on ways to replace missing source voice in case of patients after total laryngectomy. The commonly used methods of voice rehabilitation are mentioned. Simple computational models are used to explore several principles of generating artificial source voice. Based on the knowledge of how a healthy human voice is generated, one of the ways to generate artificial source voice was chosen – a reed-based element in the configuration (-, +). The function of the reed-based element is based on a periodic bending of the reed and in the airflow cutoff created by this motion. The (-,+) configuration of the reed-based element causes a different behaviour, when compared to healthy vocal folds, important is, however, whether the generated acoustic signal has the right spectral characteristics, which enable the generation of voiced vowels of the human speech. Both experimental and computational models are used to study the behaviour of the reed-based element. The design of the experimental model is based on the preliminary experiments with simple reed-based elements, which were carried out at the beginning of my studies. The new experimental model is designed in such a way, that it enables changes to the reed geometry and its position towards the reed stop. The measurements carried out on the experimental model are mainly acoustical (measurements of the generated acoustical signal), but optical measurements of the reed´s movement and position are possible and used as well. Because of the nature of the reed-based element´s behavior, the fluid structure interaction must be taken into consideration in the computational model. A two-way model of fluid structure interaction is used between the fluid part of the computational model and the structural one. A partitioned solution is used to solve the fluid-structure interaction. The effect of specific input parameters on the function of both models (experimental and computational) is monitored. The influences of input parameters on the basic frequency of the generated signal (source voice), on the stability of the function and on other important characteristics are evaluated. The final chapters focus on the design of voice prosthesis in general. Some specific issues, which need to be solved when designing voice prosthesis, are highlighted.
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Interactions and aggregation in hyaluronan-aminoacid-surfactant systems
Venerová, Tereza ; Velebný, Vladimír (referee) ; Pekař, Miloslav (advisor)
The effect of native hyaluronan addition on CMC of excluded surfactants (Tween 20, BETADET THC 2, SDS, CTAT a CTAB) in physiological solution (0,15 M NaCl) has been investigated by fluoresence spectroscopy with Pyrene and Nile red as probes. The greatest influence on CMC has been observed in systems with cationic surfactant. System of cetyltrimethylamonnium bromid has been closely studied. Solubilization experiments with a hydrophobic dye Sudan red has been realized and aggregation number of this system has been determinated via fluorescence quenching with cetylpyridinium chloride as quencher and Pyrene as fluorescence probe. Addition of hyaluronan (native or hydrophobicaly modified) reduces aggregation number of system.
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Aggregation processes in amphiphil-polymer system
Šejnohová, Michaela ; Márová, Ivana (referee) ; Pekař, Miloslav (advisor)
This Bachelor´s thesis is focused on the exploration of polyelectrolyte-surfactant system by fluorescence spectroscopy with pyrene as fluorescent probe. Cationic cetyltrimethylammonium bromide (CTAB) was used as a surfactant. Native hyaluronan was used as polyelectrolyte. Hyaluronan was used in one constant molecular weight and one constant concentration. The whole system was prepared in an aqueous environment. Interactions were studied in area between critical aggregation concentration (CAC) and critical micelle concentration (CMC). The influences of the concentration of pyrene and the effect of the way of the samples preparation on aggregation behavior were also studied. It was found that above the critical aggregation concentration exists an area where stable properties of aggregates can be found. The concentration of pyrene has a major effect on the fluorescence properties of the system. Preparation of samples affects the aggregation of the system. At higher surfactant concentrations, above the stable area, was observed phase separation and gel formation.
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Mist
Volkova, Zoya ; Kudělka, Vladimír (referee) ; Vaněk, Vojtěch (advisor)
The "Mist" is a visual narrative project on the border between 2D digital games and interactive animation. The virtual space here thematically take place between key words such as dream, sleep, limbo, phase of sadness, phase of dying. Subsequently, a form of metaphor is elaborated with the help of a non-existent landscape with specific elements (trees, plants, and others). Road through the countryside, road through the mist. Part of the movement of virtual space is a survey of linear processing over time.
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Hydrogels amino-dextran-surfactant: phase diagram
Daňková, Kristýna ; Hurčíková, Andrea (referee) ; Pekař, Miloslav (advisor)
This bachelor thesis deals with a study about hydrogel systems based on the physical interactions of the oppositely charged particles, specifically interactions between positive polyelectrolyte and negative detergent. The phase diagrams were created based on the visual evaluation of results of the laboratory experiment, which is a part of this thesis, for in advance chosen concentration of the polymer diethylaminoethyl-dextran hydrochloride and detergents sodium dodecyl sulphate and sodium tetradecyl sulphate. These phase diagrams characterize incurred dextran systems.
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ENOUGH
Giertlová, Elena ; Smetana, Matěj (referee) ; Vaněk, Vojtěch (advisor)
Project deals with the development of a 2D, roleplaying videogame for the computer platform. Theoretical part of the thesis is focused on background of pixelart in videogames, as well as game and storytelling cliche, while both of these aspects are used in the final project. Practical part is the design of characters, enviroment and scenes, and the complete realization of a prototype for pixelart videogame named ENOUGH, with the visual of retro games for old platforms. Its story is being shown as a cliche as well, though with the strong symbolism refering to authors psychique and on the mental health or memories.
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Investigation of Ionizing Radiation Infuence to the Communication Systems of Satellites
Golubev, Martin ; Hobst, Leonard (referee) ; Katovský, Karel (advisor)
This master thesis discuss about ionizing radiation, interaction with matter and effects on her. In the work is discussed differend types of interactions of directly ionizing radiation and indirectly ionizing radiation. Below is an overview of methods of shielding from all of types of ionizing radiation. Second part of this thesis discuss about single event effects in semiconductors which are cause by ionizing radiation. At the end is described design of measuring instrument included FPGA chips. This design is discused both from point of wiew hardware and software too.
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Study on the Mobility of Selected Representatives of Pharmaceuticals in Natural Systems
Bednárová, Paula ; Pořízka, Jaromír (referee) ; Kalina, Michal (advisor)
This diploma thesis focuses on interactions of chosen pharmaceuticals with soil and study their mobility. First part is devoted to the characteristics of the most common pharmaceuticals that appear in the environment, specifically antibacterial chemoterapeutics and analgetics. Subsequently, the occurrence of the pharmaceuticals in environment, their sources and effects are described. Further, the work focuses on soil components and soil organic matter. In conclusion of the theoretical part is the description of used analytical method for processing of the results and also the current state of the problematics. In the practical part of the thesis the experiments were made and analyzed and further served for better understanding of adsorption and interactions of chosen pharmaceuticals with soil and humin acids as the main reactive part of the soil.
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Optimizing the determination of distribution of surfactant at phase separation in polymer-surfactant system
Sátorová, Kateřina ; Pekař, Miloslav (referee) ; Mravec, Filip (advisor)
This diploma thesis is focused on the determination of distribution a surfactant at phase separation in polymer-surfactant system. Sodium hyaluronate of three molecular weights was chosen as a polymer, CTAB was used as a surfactant. The experiments were performed in an environment of 0,15 M NaCl. The measurement of the CTAB concentration in samples was based on the formation of coloured complexes of CTAB and picric acid in chloroform. UV-VIS spectroscopy was used for the detection of these complexes. The content of CTAB was determined in four gels of different composition (2% Hya + 200 mM CTAB, 2 % Hya + 50 mM CTAB, 0,5 % Hya + 200 mM CTAB, 0,5 % Hya + 50 mM CTAB). All gels were gradually washed five times with 0,15 M NaCl. The content of CTAB was determined for newly prepared gels and for gels after 2 and 4 months since the preparation. Initial concentrations of CTAB and hyaluronan have greater influence on the distribution of CTAB after phase separation, than the molecular weight of hyaluronan. The content of CTAB in newly prepared gels and after 4 months since preparation is very similar and demonstrates the stability of the system.
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Trees Have the Power
Mikušková, Nina ; Fajnor, Richard (referee) ; Kovářová, Marta (advisor)
The project "Trees Have The Power" is being developed since 2013 and revolves around the strength of interpersonal connections experienced throughout our lives. It points out the reality, that we all create our own micro-cosmos around us, shaped and expanded by every new person we meet. First phase of the project involved exhibition of a tree within a gallery, which served as a metaphor of an ever expanding organism. For the second phase an online social platform was developed, to map out and connect my personal contacts. The third outcome offers space to present the "tree". By involving people from my own personal tree of connections, we are creating lectures, interactive events, concerts, film screenings, and discussions focused on multiple aspects of life. The aim is both to test the skills and initiative of a specific community as a driving force in sharing and accumulating knowledge and experience; and at the same time to demonstrate the magnitude of impact of such activity. This unorthodox framework of encounter offers opportunity to generate new perspectives within the community, and enrich the audience.
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