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MRI Acquisition and Preprocessing of Image Sequences for Clinical Perfusion Imaging
Krchňavý, Jan ; Bartoš, Michal (referee) ; Jiřík, Radovan (advisor)
This thesis describes the theory for static and dynamic magnetic-resonance imaging using contrast agents affecting T1 relaxation time. The available acquisition methods in the specified facility of Masaryk Oncological Institute in Brno are described. The sequences for subsequent experimental measurements are selected. The used phantoms are described. Acquisition protocol for measuring is described briefly and the evaluation method for the measured data is suggested. The best acquisition sequence and a method of measurements is chosen influenced by estimation of relaxation time T1, sensitivity and signal to noise ratio. Perfusion analysis is executed and perfusion parameters are calculated. The work was supported by the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101).
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Tilt sensors
Hájek, Tomáš ; Caha, Luděk (referee) ; Beneš, Petr (advisor)
The topic of the Bachelor's thesis are MEMS sensors of inclination, which find their use inside integrated circuits, equipment of aerospace and automobile industry, but also in ordinary electrical appliance. The work serves the reader to build a grasp over production, usage, basic principles. Finally, it offers an overview of sensors to ease the orientation on the market. The design of the physical model, which can be used to prevent the sensor from apperance of mathematical errors, is tested in the practical part.
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Qualitative comparison of MEMS vibration sensors
Hasík, Stanislav ; Havránek, Zdeněk (referee) ; Klusáček, Stanislav (advisor)
The aim of this bachelor thesis is a qualitative parameter validation of MEMS vibration sensors using calibration devices from the companies SPECTRA a Brüel & Kjr. First part of study deals with different types of MEMS vibration sensors on the piezoresistive, capacitive and thermal principle of operation. The study also deals with primary and secondary methods of calibration of vibration sensors and devices used for these calibration methods. The second part of the thesis is to use the calibration chains and secondary calibration methods to verify the sensitivity and temperature dependences of three particular MEMS accelerometers from the companies STMicroelectronic, MEMSIC and Panasonic. The measured characteristics are compared with catalog datasheets. In the end of the thesis are also discussed the possibility of the suppression these temperature effects.
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Classification and modelling of LED light sources in terms of sensitivity to supply voltage fluctuations
Hudáč, Tomáš ; Kukačka, Leoš (referee) ; Drápela, Jiří (advisor)
Cieľom tejto práce je preskúmať a charakterizovať celkovú odolnosť voči flickru v LED svetelných zdrojoch dostupných na súčasnom trhu, a vytvoriť modelu LED svetelného zdroja. Na nájdenie reprezentatívnych vzoriek LED svetelných zdrojov, bola prevedená analýza online trhu, ktorá ukazuje najpredávanejšie typy. Na základe výsledkov z analýzy sa získalo 31 vzoriek. S rôznymi LED technológiami a rôznymi možnosťami regulácie výkonu, napríklad bezdrôtovo alebo triakom. Vykonaním meraní za ideálnych podmienok napájania a rozobraním niektorých vzoriek boli celkovo identifikované 4 hlavné triedy s rôznymi topológiami napájacích obvodov. Ďalej sa vykonali testy ich citlivosti na blikanie a imunitou voči blikaniu. Na základe získaných výsledkov testov bola každá topológia ovládača ohodnotená podľa jej celkovej odolnosti voči blikaniu. V závere práce bol navrhnutý model v Simulinku, ktorý úspešne simuloval IH GF krivky v porovnaní s nameranými hodnotami
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Electronic temperature measurement for a grill
Svoboda, David ; Burian, František (referee) ; Fiedler, Petr (advisor)
The work deals with methods of temperature measurement, electrical and non-electrical. Discussing the advantages and disadvantages of electrical methods of temperature measurement for applicability in the grill. It also discusses the selection of a suitable sensor to measure the temperature inside the grill. Subsequent design and implementation of the measuring system where the emphasis is on accuracy.
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Design and verification of a thermodynamic sensor with a focus on high sensitivity
Staroštík, Petr ; Jankovský, Jaroslav (referee) ; Otáhal, Alexandr (advisor)
This work deals with the issue of using bolometers, calorimeters a thermo-dynamic sensor in measuring temperature and heat. In the case of bolometers and microcalorimeters are described their properties and limit parameters. The work focuses more closely on the construction of a thermodynamic sensor from discrete components with a focus on achieving high sensitivity. The sensitivity of the thermodynamic sensor was measured in an experiment with a defined heat change and evaluated. Using this experiment was set the measurement methodology, which was subsequently modified. As part of the bachelor's thesis was designed a new sensor for a thermodynamic sensor and was measured its sensitivity.
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Indikátory zranitelnosti dopravy změnou klimatu
Mertl, Jan
Příspěvek je věnován vyhodnocení zranitelnosti dopravy ČR projevy změny klimatu, a to na základě indikátorů zranitelnosti. Metodickým základem indikátorů zranitelnosti je koncept zranitelnosti rozlišující tři základní komponenty zranitelnosti – expozici, citlivost a adaptační kapacitu.
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Vývoj imunologických testů pro detekci nebezpečných bakteriálních patogenů
Šmídová, Lada
The aim of the thesis was to develop an immunoassay for the detection of dangerous bacterial pathogen, methicillin-resistant Staphylococcus aureus (MRSA). MRSA infections cause global problems in health facilities which provide acute and follow-up care in inpatient and outpatient parts. That is why early and rapid diagnosis and targeted thereapies are very important for the subjects. E. coli was purified using the QIAquick PCR kit Purificatin isolated bacterial constructs, which were subsequently purified and dialyzed. The recombinant protein PBP2a in different concentrations was applied to a nitrocellulose membrane in the form of lines. Furthermore was performed optimized blot-line method for the detection of specific antibodies against the recombinant antigen PBP2a in the classes IgG, IgA and IgM. Several different concentrations of the conjugate Goat Anti-human IgG-AP, Goat Anti-human IgA-AP or Goat anti-Human IgM-AP were used for the detection. The color intensity of each line of the strip was evaluated with Immunoblot software. The measured values were used to determine diagnostic sensitivity, specificity and overall diagnostic match. Further testing of precision was carried out under repeatability conditions (intra-assay) and reproducibility (inter-assay). Precision of the method was expressed by coefficient of variation. As the most suitable for the manufacture of a IgG kit was determined the concentration of the antigen PBP2a from 0.30 mg/ml to 0.45 mg/ml and the concentration of IgG conjugate from 1:1500 to 1:1800. For class IgA as the most appropriate antigen was determined concentration PBP2a from 0.40 mg/ml to 0.52 mg/ml and conjugate concentrations of IgA from 1:500 to 1:1000. The coefficient of variation under repeatability conditions for the entire range of the IgG class is 10.09 %, and for IgA is 8.91 %. Variation coefficient reproducibility conditions for the entire range of the IgG class is 9.23 % and for IgA is 9.60 %. Precision of the method under conditions of repeatability and reproducibility for classes IgG and IgA meets the criteria for the manufacture of a diagnostic kit. Titration results showed that particular batch of cards made of nitrocellulose membrane coated with antigen PBP2a must always be verified on the panel of reference samples and the values of concentrations (for both antigen and conjugate) should be set according to the needs, but differently for the class of immunoglobulins IgG and IgA.
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