National Repository of Grey Literature 11 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Selected aspects of methotrexate treatment in patients with rheumatoid arthritis
Hloch, Karel ; Pávek, Petr (advisor) ; Souček, Miroslav (referee) ; Tomčík, Michal (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Social and Clinical Pharmacy Doctoral Degree Program Clinical and Social Pharmacy Candidate MSc. Karel Hloch Supervisor prof. PharmD. Petr Pávek, Ph.D. Advisor assoc. prof. MUDr. Tomáš Soukup, Ph.D.; PharmD. Martin Doseděl, Ph.D. Title of Doctoral Thesis: Selected aspects of methotrexate treatment in patients with rheumatoid arthritis Introduction and objectives Rheumatoid arthritis (RA) is an autoimmune disease typically connected with chronic inflammation of the joints, causing their swelling and pain. The prevalence of RA is about 1% in the general population. A crucial role in higher morbidity and mortality in RA patients has been associated with increased inflammatory activity. Methotrexate (MTX), a drug with immunosuppressive activity, is the most frequent drug of choice used in RA therapy. It seems that main anti-inflammatory effect is mediated via release of purine nucleoside adenosine. The status of patients with inflammatory diseases is influenced by activation of A2a and A3 adenosine receptors. High caffeine (adenosine receptor antagonist) consumption may therefore lead to alteration of MTX treatment efficacy. 1) The aim of first study was to determine whether RA patients who had discontinued...
Ambulatory blood pressure monitoring and hypertension in children with diabetes mellitus type 1
Šuláková, Terezie ; Janda, Jan (advisor) ; Svačina, Štěpán (referee) ; Souček, Miroslav (referee)
Objective: to evaluate the diagnostic efficacy of the office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) in the assessment of hypertension (HTN) in children with diabetes mellitus type 1 (DM1). Methods: We analyzed OBP and ABPM measurements in 84 diabetic children (43 boys) obtained at a median age of 14.9 years and 6.3±3.5 years after diagnosis of DM1. OBP and ABPM results were converted into standard deviation scores (SDS). In addition, we analyzed blood pressure loads and nighttime dipping. The comparison between OBP and ABPM was performed using kappa coefficient and receiver operator curve (ROC). Results: HTN was diagnosed in 43/84 (51%) patients using OBP (>95th percentile) and in 24/84 (29%) patients using ABPM (≥95th percentile during 24h, day or night). Both methods were in agreement in 33 ABPM normotensive and 16 ABPM hypertensive patients (most had nighttime HTN); 32% patients had white coat HTN and 9.5% patients had masked HTN. The kappa coefficient was 0.175 (95% CI -0.034 to 0.384) suggesting poor agreement between OBP and ABPM. Diastolic OBP was a better predictor of ABPM HTN (ROC AUC=0.71±0.06) than systolic OBP (AUC= 0.58 ± 0.07). The percentage of non-dippers ranged from 7 to 23% in ABPM normotensive patients and 21-42% in ABPM hypertensive patients who also had...
Selected aspects of methotrexate treatment in patients with rheumatoid arthritis
Hloch, Karel ; Pávek, Petr (advisor) ; Souček, Miroslav (referee) ; Tomčík, Michal (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Social and Clinical Pharmacy Doctoral Degree Program Clinical and Social Pharmacy Candidate MSc. Karel Hloch Supervisor prof. PharmD. Petr Pávek, Ph.D. Advisor assoc. prof. MUDr. Tomáš Soukup, Ph.D.; PharmD. Martin Doseděl, Ph.D. Title of Doctoral Thesis: Selected aspects of methotrexate treatment in patients with rheumatoid arthritis Introduction and objectives Rheumatoid arthritis (RA) is an autoimmune disease typically connected with chronic inflammation of the joints, causing their swelling and pain. The prevalence of RA is about 1% in the general population. A crucial role in higher morbidity and mortality in RA patients has been associated with increased inflammatory activity. Methotrexate (MTX), a drug with immunosuppressive activity, is the most frequent drug of choice used in RA therapy. It seems that main anti-inflammatory effect is mediated via release of purine nucleoside adenosine. The status of patients with inflammatory diseases is influenced by activation of A2a and A3 adenosine receptors. High caffeine (adenosine receptor antagonist) consumption may therefore lead to alteration of MTX treatment efficacy. 1) The aim of first study was to determine whether RA patients who had discontinued...
Depression and Insulin Resistance
Hess, Zdeněk ; Rosolová, Hana (advisor) ; Šimon, Jaroslav (referee) ; Souček, Miroslav (referee) ; Beran, Jiří (referee)
Introduction: Metabolic syndrome and depression are considered to be important risk factors for the development of cardiovascular diseases. The prevalence of metabolic syndrome is estimated to be around 25% of the adult population in industrialized countries, including the population of Czech Republic. The prevalence of depression is estimated to be around 15% of the same adult population. It is not clear yet on the base of poor literature, which is so far available, whether there is a causal relationship between these factors or not. Objective: To try to find a relationship between metabolic syndrome and depression in a population sample using clinical and metabolic parameters. Methods: The prevalence of depressivity or other psychopathologies was evaluated with the use of self-report questionnaires in a randomly selected population sample of 259 people living in Pilsen. The questionnaires were mailed to the subjects. Those of them who responded were invited to the examination of anthropometric and laboratory parameters defining the metabolic syndrome and to the examination of some other parameters. The occurrence of risk factors of the metabolic syndrome of insulin resistance and the relationship between depression and metabolic syndrome was investigated. Metabolic syndrome of insulin resistance...
Aspirin in the secondary prevention of ischemic stroke
Adámek, Tomáš ; Alušík, Štefan (advisor) ; Kalvach, Pavel (referee) ; Souček, Miroslav (referee)
Introduction: The recurrence of the cerebral ischemic stroke after a history of TIA or ischemic stroke is 3-4% per year. One way of reducing the risk of reccurence is using antiplatelet therapy. The aim of our study was to investigate the effect of aspirin. Even though, newer antiplatelet drugs were developed, their risk/benefit profile has not been proved to be better than aspirin. Reasons for using aspirin in secondary prevention are: the longest experience, clearly proven effect in many studies and low price. On the other hand, aspirin prevents only 25% of strokes, thus there is wide space for searching for causes of failed therapy and alternative therapeutic ways. Noncompliance of aspirin use and embolic events are usually indicated as the most common causes of an ineffective therapy. The goal of our study was to find the antiplatelet therapy effectivity in patients with history of stroke treated with aspirin in daily dose of 100mg. We assured 100% compliance among these patients and as much as possible minimalized a likelihood of embolic causes of strokes. What is more, we tried to find out whether an insuffient suppression of 11-dehydrotromboxane B2 correlates with comorbidities, other used medication or laboratory parameters. Furthermore, whether by administrating an increased dose of...
Aspirin in the secondary prevention of ischemic stroke
Adámek, Tomáš ; Alušík, Štefan (advisor) ; Kalvach, Pavel (referee) ; Souček, Miroslav (referee)
Introduction: The recurrence of the cerebral ischemic stroke after a history of TIA or ischemic stroke is 3-4% per year. One way of reducing the risk of reccurence is using antiplatelet therapy. The aim of our study was to investigate the effect of aspirin. Even though, newer antiplatelet drugs were developed, their risk/benefit profile has not been proved to be better than aspirin. Reasons for using aspirin in secondary prevention are: the longest experience, clearly proven effect in many studies and low price. On the other hand, aspirin prevents only 25% of strokes, thus there is wide space for searching for causes of failed therapy and alternative therapeutic ways. Noncompliance of aspirin use and embolic events are usually indicated as the most common causes of an ineffective therapy. The goal of our study was to find the antiplatelet therapy effectivity in patients with history of stroke treated with aspirin in daily dose of 100mg. We assured 100% compliance among these patients and as much as possible minimalized a likelihood of embolic causes of strokes. What is more, we tried to find out whether an insuffient suppression of 11-dehydrotromboxane B2 correlates with comorbidities, other used medication or laboratory parameters. Furthermore, whether by administrating an increased dose of...
Insulin resistance and cholesterol metabolism in obese patients with type 1 diabetes mellitus - impact of weight reduction
Jiráčková, Jana ; Šmahelová, Alena (advisor) ; Souček, Miroslav (referee) ; Svačina, Štěpán (referee)
Insulin resistance and cholesterol metabolism in obese patients with type 1 diabetes mellitus - impact of weight reduction. Diabetes mellitus type 1 is characterized with an absolute insulin deficiency. Deterioration of cholesterol metabolism is well known in this disease, cholesterol absorption is typically elevated. Obesity, on the other hand, is accompanied with lower insulin sensitivity, that is known to increase cholesterol synthesis and decrease cholesterol absorption. Obese type 1. diabetics thus represent, from the metabolic view, an interresting combination of absolute and relative insulin deficiency. Aims: The aim of this study was to characterize relation of insulin resistance and representative markers of cholesterol metabolism in obese type 1 diabetics; and to characterise their dynamics during defined weight reduction programme. Methods: Metabolic and antropometric parameters of obese and lean patients with diabetes mellitus type 1. were compared one time (Phase I). The dynamics of followed parameters of subgroup of obese patients was characterized during the weight reduction programme in Phase I (before intervention), Phase II (after one week of fasting + three weeks on a diet with 150g saccharides per day) and in Phase III (after one year on a diet with 225 saccharides per day). In...
Ambulatory blood pressure monitoring and hypertension in children with diabetes mellitus type 1
Šuláková, Terezie ; Janda, Jan (advisor) ; Svačina, Štěpán (referee) ; Souček, Miroslav (referee)
Objective: to evaluate the diagnostic efficacy of the office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) in the assessment of hypertension (HTN) in children with diabetes mellitus type 1 (DM1). Methods: We analyzed OBP and ABPM measurements in 84 diabetic children (43 boys) obtained at a median age of 14.9 years and 6.3±3.5 years after diagnosis of DM1. OBP and ABPM results were converted into standard deviation scores (SDS). In addition, we analyzed blood pressure loads and nighttime dipping. The comparison between OBP and ABPM was performed using kappa coefficient and receiver operator curve (ROC). Results: HTN was diagnosed in 43/84 (51%) patients using OBP (>95th percentile) and in 24/84 (29%) patients using ABPM (≥95th percentile during 24h, day or night). Both methods were in agreement in 33 ABPM normotensive and 16 ABPM hypertensive patients (most had nighttime HTN); 32% patients had white coat HTN and 9.5% patients had masked HTN. The kappa coefficient was 0.175 (95% CI -0.034 to 0.384) suggesting poor agreement between OBP and ABPM. Diastolic OBP was a better predictor of ABPM HTN (ROC AUC=0.71±0.06) than systolic OBP (AUC= 0.58 ± 0.07). The percentage of non-dippers ranged from 7 to 23% in ABPM normotensive patients and 21-42% in ABPM hypertensive patients who also had...

National Repository of Grey Literature : 11 records found   1 - 10next  jump to record:
See also: similar author names
21 SOUČEK, Martin
21 Souček, Martin
5 Souček, Michal
3 Souček, Milan
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