National Repository of Grey Literature 14 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Normal pressure hydrocephalus- Complex approach to diagnosis and treatment
Skalický, Petr ; Bradáč, Ondřej (advisor) ; Haninec, Pavel (referee) ; Keller, Jiří (referee)
Normal pressure hydrocephalus (NPH) is an important part of the differential dia- gnosis of the causes of cognitive deficit, gait disorder and incontinence in elderly patients. This is especially true for idiopathic normal pressure hydrocephalus (iNPH), to which this thesis is dominantly devoted. A number of factors contribute to the course of the disease, therefore a comprehensive approach evaluating multiple variables accompanying the disease, comorbid diseases or considered diseases in the differential diagnosis, as well as a comprehensive approach to therapy, which contains much more than just the im- plantation of a derivation system for the drainage of cerebrospinal fluid, can improve, not only, the quality of life of these patients. The mainstay of the dissertation thesis are two first-author articles. The first study deals with morphological parameters obtained during MRI examination and their ability to predict improvement in gait after shunt implantation in iNPH patients. We evaluated the predictive performance of score for evaulating disproportionately enlarged subarachnoid space hydrocephalus (DESH score), callosal angle and cingulate sulcus sign against the reference standard in the form of functional testing - lumbar infusion test (LIT) and external lumbar drainage (ELD). In the...
The Contribution of Oskar Heiroth to the Formation of Classical German Ethology
Bradáč, Ondřej ; Komárek, Stanislav (advisor) ; Hermann, Tomáš (referee)
Oskar Heinroth was a German zoologist and is frequently considered as the founder of ethology. Thanks to his lifetime observing of animals, especially birds, made he the conclusion that movement, display of behavior and other signs which haven't been taken into account until his days are equally important for the right animal classification as morphology. He is a discoverer of species typical instinctive behavior and he observed as the first one several other ethological phenomenons as imprinting, drop-off of the treshold value of the signal or idle-running reactions. He iniciated a more pragmatic sight into animal psychics and laid foundations of ethological methodics. Thanks to his publication a darwinistic attitude got access into psychological sciences. Regarding his evidence Konrad Lorenz, Erich von Holst and Nicholas Tinbergen constituted ethology as integrated science, which has later been confirmed on the premisies of universities.
Biological and related theories of aggression and its humoral regulation
Bradáč, Ondřej ; Komárek, Stanislav (advisor) ; Havlíček, Jan (referee)
Aggression is a phenomenon which acquired a substantial share on attention of biological literature, especially since the beginning of 20th century. In this thesis, various approaches to the problem from the field of biology are summarized. Intensified attention is dedicated to the theoretical concepts of aggression, especially the concepts consulting the problem of aggression from the evolutionary point of view and to the research on the field of hormonal regulation of aggression, stressing out the role of the hormone testosterone, and to particular hypothesis, which take account on its mutual relationship with behavior. The empirical part of the thesis is dedicated to verification of premises of the challenge hypothesis according to the relationship between testosterone and aggressive behavior. Significant findings of the empirical part refer to the existence of a link between basal level of testosterone and aggressive tendencies and to the existence of a negative link between basal level of testosterone and its increase in reaction to a competitive situation.
The Study of hydration models on platinum complexes important in anticancer cure
Bradáč, Ondřej ; Burda, Jaroslav (advisor) ; Záliš, Stanislav (referee)
In this work, there are studied some biologically important platinum complexes, cisplatin analogues, with central platinum atom in state Pt(II), or Pt(IV). I concentrated on the hydration processes of the examined complexes. Thermodynamical and kinetical aspects of reactions were studied and NPA charge analyses were carried out, too. All computations were performed on DFT level with B3LYP functional. All reactions were considered in vacuum. Supermolecular approach was used for energy calculations.
Deriving predictive pathophysiological markers from ICP analysis
Mládek, Arnošt ; Bradáč, Ondřej (advisor) ; Haninec, Pavel (referee) ; Mraček, Jan (referee)
Deriving predictive pathophysiological markers from ICP analysis RNDr. Arnošt Mládek, Ph.D. December 13, 2021 Abstract Intracranial pressure (ICP) is an irreplaceable neurointensive care parameter and is an area under intensive research. The great diagnostic importance of ICP is underlied by two factors: (1) the central nervous system (CNS) is placed in a rigid cranial vault and even small local expansive processes (e.g. tumors, abscesses, bleeding) may lead to intracranial hypertension; (2) a specific property of the CNS is a rather uniform response to various pathological events since many etiologically heterogeneous diffuse injuries of neural tissue lead to oedema elevating ICP. The complexity of ICP monitoring stems from the neurosurgical insertion of the pressure sensor into the intracranial space and the associated risks of bleeding, neuroinfection and brain tissue damage. Intracranial pressure is more than just a number on a bedside monitor, even though in clinical practice this simplification is rather common. Similarly to electrocardiogram (ECG) signals whose information content goes well beyond heart rate calculation, understanding of ICP dynamics can provide us with insight into the current clinical status as well as prediction of further evolution. The mainstay of the dissertation thesis are...
The use of experimental MR imaging in neurosurgery, diagnostic markers in expansive brain processes. Diagnostic markers of patients with normal pressure hydrocephalus
Vlasák, Aleš ; Bradáč, Ondřej (advisor) ; Hejčl, Aleš (referee) ; Krahulík, David (referee)
Despite decades of research of normal pressure hydrocephalus (NPH), a clear pathophysiological mechanism of the disease is sill unknown. This results in the absence of a unambiguous diagnostic biomarker. Moreover, NPH in contrast to similar neurodegenerative diseases is curable by insertion of a ventrikulo-peritoneal shunt. Now the diagnostics is based on invasive functional testing, on the contrary, imaging methods play only a supporting role. This work is processed with an effort to find a sufficiently sensitive and specific biomarker of MRI imaging using advanced analytical methods. For this reason, the structural volumetry and the phase contrast method were tested. The individual partial results of both of these modalities have already been described in the literature, but the conclusions were controversial. The main contribution of this work is the range of tested parameters and their to date untested advanced analysis - accurate automatic segmentation in volumetric study and machine learning algorithms in phase contrast study. In a volumetric study, we segmented a total of 26 structures in 74 patients (29 with diagnosed NPH, 45 without NPH). In the case of preoperative examination, we demonstrated statistically significant differences in the size of the left hippocampus, corpus callosum, left...
The Study of hydration models on platinum complexes important in anticancer cure
Bradáč, Ondřej
In this work, there are studied some biologically important platinum complexes, cisplatin analogues, with central platinum atom in state Pt(II), or Pt(IV). I concentrated on the hydration processes of the examined complexes. Thermodynamical and kinetical aspects of reactions were studied and NPA charge analyses were carried out, too. All computations were performed on DFT level with B3LYP functional. All reactions were considered in vacuum. Supermolecular approach was used for energy calculations.
Treatment for Brain Arteriovenous Malformations
Bradáč, Ondřej ; Beneš, Vladimír (advisor) ; Haninec, Pavel (referee) ; Vaverka, Miroslav (referee)
Introduction: The surgical and endovascular results of the treatment of pial AVM provided at our Neurosurgical centre are presented. These results are supported by neuropsychological outcomes of subgroup of treated patients. Going by these results and by an overview of literary data on the efficacy and complications of each therapeutic modality, the optimal algorithm of indications is presented Cohort of patients: The main series comprises 222 patients aged 9 to 87 years treated in the years 1998 - 2013. The surgical group consists of 85 patients, 55 patients received solely endovascular treatment. Thirty-four patients were consulted and referred directly to the Radiosurgical unit. The remaining 48 were recommended to abide by the strategy of "watch and wait". A subgroup of 66 patients, who underwent treatment of AVM was neuro-psychologically tested at least two years after treatment using a battery of tests constructed specifically for this study. A control group consisted of 10 subjects without any neurological disease. Results: In the surgical group, serious complications were 3.5% at a 96.5% therapeutic efficacy. As for AVM treated with purely endovascular methods, serious procedural complications were seen in 5.5% of patients, with efficacy totalling 36.4%. One observed patient suffered...
Treatment for Brain Arteriovenous Malformations
Bradáč, Ondřej ; Beneš, Vladimír (advisor) ; Haninec, Pavel (referee) ; Vaverka, Miroslav (referee)
Introduction: The surgical and endovascular results of the treatment of pial AVM provided at our Neurosurgical centre are presented. These results are supported by neuropsychological outcomes of subgroup of treated patients. Going by these results and by an overview of literary data on the efficacy and complications of each therapeutic modality, the optimal algorithm of indications is presented Cohort of patients: The main series comprises 222 patients aged 9 to 87 years treated in the years 1998 - 2013. The surgical group consists of 85 patients, 55 patients received solely endovascular treatment. Thirty-four patients were consulted and referred directly to the Radiosurgical unit. The remaining 48 were recommended to abide by the strategy of "watch and wait". A subgroup of 66 patients, who underwent treatment of AVM was neuro-psychologically tested at least two years after treatment using a battery of tests constructed specifically for this study. A control group consisted of 10 subjects without any neurological disease. Results: In the surgical group, serious complications were 3.5% at a 96.5% therapeutic efficacy. As for AVM treated with purely endovascular methods, serious procedural complications were seen in 5.5% of patients, with efficacy totalling 36.4%. One observed patient suffered...
Biological and related theories of aggression and its humoral regulation
Bradáč, Ondřej ; Komárek, Stanislav (advisor) ; Havlíček, Jan (referee)
Aggression is a phenomenon which acquired a substantial share on attention of biological literature, especially since the beginning of 20th century. In this thesis, various approaches to the problem from the field of biology are summarized. Intensified attention is dedicated to the theoretical concepts of aggression, especially the concepts consulting the problem of aggression from the evolutionary point of view and to the research on the field of hormonal regulation of aggression, stressing out the role of the hormone testosterone, and to particular hypothesis, which take account on its mutual relationship with behavior. The empirical part of the thesis is dedicated to verification of premises of the challenge hypothesis according to the relationship between testosterone and aggressive behavior. Significant findings of the empirical part refer to the existence of a link between basal level of testosterone and aggressive tendencies and to the existence of a negative link between basal level of testosterone and its increase in reaction to a competitive situation.

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