National Repository of Grey Literature 57 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Mechanisms of apoptosis induction and inhibition by fatty acids in pancreatic β-cells
Šrámek, Jan ; Kovář, Jan (advisor) ; Brunerová, Ludmila (referee) ; Šeda, Ondřej (referee)
Recently, diabetes mellitus type 2 (DMT2) represents one of the most important metabolic diseases according to its incidence and economic impacts. One of the main reasons of this diesease is loss of function and viability of pancreatic β-cells due to the effect of increased levels of saturated fatty acids (FAs). Unsaturated FAs are better tolerated by β-cells. They are even capable of inhibiting detrimental effects of saturated FAs. Molecular mechanisms of apoptosis induction in pancreatic β-cells by saturated FAs as well as mechanisms of inhibition of this induction by unsaturated FAs are not completely elucidated. The main aim of this study was to contribute to elucidation of these mechanisms. Concerning human pancreatic β-cell line NES2Y we demonstarted: (1) Activation of caspase-2 by stearic acid (SA), in apoptosis inducing concentration (1 mM), is not crucial for the process of apoptosis induction. However, this caspase modulates SA-induced endoplasmic reticulum (ER) stress pathways. (2) SA (1 mM) activates the p38 MAPK signaling pathway and inhibits the ERK signaling pathway. Inhibition of the ERK signaling pathway is probably a consequance of the p38 MAPK pathway activation. However, p38 MAPK is not very likely crutial for the apoptosis induction by SA. Unsaturated oleic acid (OA, 0.2 mM) is able to...
The Symbolism of Colors as a Speculative-Fiction
Špundová, Veronika ; Bena, Julie (referee) ; Šrámek, Jan (advisor)
The bachelor's thesis is an existential dystopian statement of a human actor. It is an object into which the author - the creator - user - actor projects her critical vision of a globalized, yet very local world torn apart by several crises at the same time, in which she longs to break free from anthropocentrism or redefine it to more respect a wide range of other actors, on which we are largely dependent. It tries to grasp reality from a new perspective, even if such a perspective should be mere imagination, speculative fiction, even if it should deviate from the usual directions of knowledge and action to the unknown, such as the magical irrationality. Formally, the subject of the bachelor's thesis is DIY tent sewn from upcycled textile materials and embroidered with ornaments, symbols and organic drawings, which form a variety of relationships and narratives. Inside this "outdoor shrine" there is an object - a totem standing on a tripod, on which rests a smartphone, which through the application plays three videos depicting the human actor in various strange surreal situations.
Determination of measurement uncertainty of the optical measuring machine using a laser interferometer
Fulová, Silvia ; Jankových, Róbert (referee) ; Šrámek, Jan (advisor)
This final thesis is dealing with stating uncertainty of optical measuring device Micro-Vu Sol 311, which is located at Faculty of mechanical engineering in Brno. Overview of coordinate measuring machines (CMM for short) and analyzed present status of optical CMM is in summation. This part also includes basic metrology concepts and methodology of determination of uncertainty of measuring instrument. Content of following parts of thesis is detailed description of Micro-Vu SOL 311 machine and etalons that were used in determination of enhanced uncertainty of measurement such as gage blocks, laser interferometer and glass scale. Last part of this thesis includes summary of achieved results and recommendations for practice.
Determining the measurement accuracy of a coordinate measuring machine Zeiss UPMC Carat
Kiška, Roman ; Jankových, Róbert (referee) ; Šrámek, Jan (advisor)
The aim of this diploma thesis is to create a comprehensive study of measurement accuracy of coordinate measuring machine (hereinafter CMM) Zeiss UPMC 850 Carat S-ACC (hereinafter Zeiss Carat) for the needs of the national metrological institute in Brno in accordance with ČSN EN ISO / IEC 17025 and the follow-up system standards of the ČSN EN ISO 10360 series. Additionally, it includes the creation of instructions for the calculation of measurement uncertainty, which will be put into effect in an accredited calibration laboratory. The first part of the work focuses on the description of the current state of knowledge and the definition of basic concepts in the field of metrology and accurate measurements on CMM. The second part describes the Zeiss Carat measuring machine, identifies the individual contributors to the resulting measurement uncertainty and defines the methodology for their quantification. The last part deals with the evaluation of calibration data and the calculation of the expanded measurement uncertainty of the Zeiss Carat instrument, which is used to quantify its accuracy.
Capability assessment of a optical measuring instrument
Slíž, Michal ; Šrámek, Jan (referee) ; Jankových, Róbert (advisor)
The diploma thesis deals with the capability assessment of an optical coordinate measuring machine according to VDA 5. The capability assessment is an effective tool for deciding whether the evaluated measuring machine is capable for the intended use and under which conditions its use is possible. The theoretical part of the thesis is devoted to the analysis of coordinate measuring machines, with a closer focus on a subset of optical measuring machines and the analysis of their capability assessment procedures. In the practical part of the thesis, the selected procedure is applied on the specific measuring machine Micro-Vu Sol 311. The main contribution of this thesis is a description of the possibilities of the considered coordinate measuring machine for its further use in the educational process at the Faculty of Mechanical Engineering of Brno University of Technology.
Measurement and evaluation of the inserts using an optical scanner
Vanek, Richard ; Šrámek, Jan (referee) ; Marek, Tomáš (advisor)
This bachelor thesis focuses on problematics of scanning damaged press dies by an optical 3D scanner. The bachelor thesis starts with a description of 3D scanning, its use in various branches of industry as well as defects that can occur during scanning. This work provides an overview of the methods of 3D scanning and 3D scanners. Another part of the bachelor thesis deals with the procedure of scanning a damaged press die using the optical scanner STEINBICHLER COMET LED 5M followed by processing the acquired data and creating a 3D CAD model. In the final part, the bachelor thesis focuses on comparing and evaluating the obtained data.
Population and geographic variation in long-winged bats (Miniopterus) in the western Palaearctic
Šrámek, Jan
In this study the sexual and geographical variations in the genus Miniopterus were deeply investigated, using multidisciplinary analysis (morphometric cranial, dental, fenetic and shape analysis; molecular analysis of mt gene ND2). Different populations from western Palearctic and adjacent regions were analysed: Miniopterus schreibersii (Morocco, West Europe, Pannonia, Balkans, Crete, Near East, Middle East), Miniopterus natalensis (Yemen, Ethiopia) a Miniopterus inflatus (Ethiopia). Extensove samples of Miniopterus schreibersii were tested and existence of sexual dimorphism in cranial constitution was showed: males had generally bigger and relatively higher, shorter and narrower skulls than females; female mandibles were generally bigger than the male ones, females showed also more robust and larger teeth than males. On the other hand, males had markedly bigger canines and relatively higher P4 (in relation to other premolares). The sexes also deiffered in shape of P4 and upper molars. According to the interpopulation variation found, Miniopterus schreibersii samples from West Europe, Pannonia, Balkans, Crete, Sicily, Georgia, coastal Turkish and Moroccan areas belong most probably to the subspecies M. s. schreibersii (Kuhl, 1817). The samples from Afganistan, Iran, Azerbaijan, and from localities...
Using of climate satellite data for study of weather circulation type influence on selected meteorological parameters
Kotek, Jiří ; Žák, Michal (advisor) ; Šrámek, Jan (referee)
Cloudiness and solar radiation affect the Earth's energy and water cycle and spa- tial distribution of these parameters is also connected to the atmospheric pressure field and atmospheric circulation. This thesis starts with a short overview of remote sensing of the atmosphere, the EUMETSAT organisation and its section CM SAF which focuses on the uses of satellite data for climate monitoring. Next is a description of cloud and ra- diation products used in this thesis. Daily means of these products in the Czech Republic are then used to calculate mean values, trends and anomalies for the whole time series. Obtained values are compared based on the weather circulation type using the Brádka classification. 1
Not So Close That Breck
Smrekovský, Adam ; Jančík, Alexandr (referee) ; Šrámek, Jan (advisor)
How to stop working, and start catching dogs, and live alone on a hill and walk down only when you need to catch a dog. But it also stops entertaining you and you start thinking about village life. And so you run away from the end of the world to the village.
Ščudla, Marek ; Doležel, Matěj (referee) ; Šrámek, Jan (advisor)
My bachelor thesis is my next music project, followed by instalation and merchandise. I was solving the questions about trends, genre and its boundaries. I was inspired by past and I was trying to fit it into contemporary context.

National Repository of Grey Literature : 57 records found   1 - 10nextend  jump to record:
See also: similar author names
20 ŠRÁMEK, Jan
5 ŠRÁMEK, Jiří
1 Šrámek, Jakub
5 Šrámek, Jiří
1 Šrámek, Josef
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