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Chiral separation of boron cluster compounds II.
Zámyslická, Yvette ; Kučera, Radim (advisor) ; Kastner, Petr (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Yvette Zámyslická Supervisor: doc. PharmDr. Radim Kučera, Ph.D. Consultant: RNDr. Ondřej Horáček, Ph.D. Title od Thesis: Chiral separations of borane cluster compounds II. This diploma thesis focuses on screening and optimisation of chiral separations of borane cluster compounds. Approximately more than half of the currently used medications are chiral compounds whose isomers can differ in biological activity. Borane cluster compounds, some of which are chiral, represent a significant substance category due to their chiral aspects which offer new possibilities in synthesis and modification of drug structures. The aim of this diploma thesis is to propose an optimised approach for the analysis of borane cluster compounds and achieve a successful separation of enantiomers. The theoretical part of the thesis focuses on the analysis of the basic principles of high-performance liquid chromatography, the importance of optical isomerism, the basic principles of chiral separations and introduction of borane clusters together with the possibilities of their usege in modern pharmacotherapy. The practical part of the thesis focuses on experimental assessment of...
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Proposal to Change the Marketing Communication of a Real Estate Agency
Kolářová, Anna ; Kučera, Radim (referee) ; Kaňovská, Lucie (advisor)
This thesis deals with a proposal to improve the marketing communication of a selected real estate agency with a primary focus on the preferences of Generation Z. The thesis is divided into three parts, the theoretical part focuses on marketing communication of services, generation Z, X and Y and the main features characterizing the real estate market. The analytical part focuses on the current situation of the selected real estate agency in the field of marketing communication, the analysis of the external and internal environment and qualitative research focusing on the preferences of Generation Z in choosing their own housing. In the proposal part, optimal changes in the field of marketing communication for the real estate agency are recommended on the basis of the analytical part.
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Detection of Harmfulness of Communication Partners and Their Networks
Kučera, Rostislav ; Homoliak, Ivan (referee) ; Očenášek, Pavel (advisor)
With the growing dependence of the population on electronic devices, the risk of data loss or misuse also increases. As the number of attacks in computer networks rises, systems for detecting malicious traffic become more important. The goal of this work is a theoretical analysis and implementation of modules for detecting malicious computer communication using machine learning methods, specifically a neural network model, and statistical analysis, which are deployed within the extended intrusion detection system Snort.
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Analysis and design of decoupling capacitors in the 65 nm CMOS digital standard library
Kučera, Radek ; Bartoš, Pavel (referee) ; Král, Vojtěch (advisor)
Tato práce se zabývá návrhem blokovacích kondenzátorů ve formě CMOS tranzistorů pro stabilizaci napájecího napětí v digitální standardní knihovně se zaměřením na 65 nm technologii. Úvod poskytuje přehled CMOS technologie a popis MOS struktur. Analýza porovnává čtyři topologie blokovacích kondenzátorů (NMOS, PMOS, CMOS, Cross-Coupled) a identifikuje Cross-Coupled jako nejlepší volbu. Poslední část se zaměřuje na návrh a optimalizaci layoutu blokovacích kondenzátorů. Byly vytvořeny čtyři různé layouty, optimalizované pro kapacitu, činitel jakosti, svodový proud a kompromis mezi těmito faktory, aby mohly být integrovány do standardních digitálních knihoven podle specifických aplikací.
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Detached house with shop of cloths and haberdashery in Praha - Libuš
Dvořáková, Hana ; Kučera, Radim (referee) ; Štěpánek, Ladislav (advisor)
The bachelor thesis is a project of a multi-storey detached house with shop of cloth and haberdashery in Prague. The house is designed for two families. The shop is located in the 1st floor and is functionally completely independent of the operation of the residential part. The entrance of the shop is located on the main street. The entrance to the residential part is on side street. The rooms are oriented to the southwest. The building has walls made of ceramic blocks Porotherm, the ceiling and the stairs are monolithic reinforced concrete. The project was worked out in a training version of Autocad, the editions were processed in the Archicad program. During processing the emphasis was on architectural and layout solutions, static requirements and safety in use.
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Proposal of Waste Elimination in the Production of Stabilizers
Kučera, Roman ; Jozefovic, Peter (referee) ; Videcká, Zdeňka (advisor)
This thesis is trying to solve the elimination of waste and the increase of effectiveness of the packaging process of the stabilizers in the Mubea Stabilizer Bar Systems s.r.o company. The current unsuitable state of the process of packaging is being analysed in this thesis with the help of the techniques and tools of the LEAN methodology. After the subsequent evaluation of the results of the analysis, the suggestion, which should improve and optimize the actual unsuitable state, is being devised.
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Detached House
Slavotínková, Radka ; Kučera, Radim (referee) ; Smolka, Radim (advisor)
This bachelor’s thesis deals with the design documentation of a detached house for two families. The house is situated in the district Slavonín in Olomouc city, catastral district Slavonín. The supporting structures of building is designed in the integrated building system Porotherm. The main building and both garages are roofed by shed and double-shell roof. Construction of roof is made like purlin system from wood components. The buildings has two floors abobe ground.
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Detached house with a coffee bar in Kroměříž
Skopalová, Vendula ; Kučera, Radim (referee) ; Štěpánek, Ladislav (advisor)
The subject of this bachelor's thesis is to design and process a construction-technical part of construction realisation documents of a new family house with two flats and a café in Kroměříž. The building is located on a flat land and comprises of a partial basement and three above ground storeys. A garage for both flats is designed in the project. The building is covered by a saddleback roof with concrete roofing. Vertical load bearing structures are made of the Porotherm system. In addition to its own project, it also includes an architectural conception, fire safety report and thermal and technical assessment of the house.
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The importance of the deformation necks in forming
Kučera, Radek ; Podaný, Kamil (referee) ; Peterková, Eva (advisor)
The aim of this bachelor thesis is elaboration of the research themed deformation necks in forming technology. Particular methods of spreading of the deformation necks are described in this thesis. The advantages and disadvantages are reviewed also as its use in practice. Moreover comparison of the most used methods of spreading of deformation necks had been carried out. Further the connection of deformation necks and forming limit diagram had been stated. The thesis also presents summary of the automated methods of deformation necks analysis.
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Yacht Club Hlucin
Kučera, Radim ; Šuhajdová, Eva (referee) ; Šuhajda, Karel (advisor)
The aim of this study is the design of Yacht club. The building is situated on a building estate No. 1303/3 of the Kozmice land registry in the recreational premises at the lakefront of „Hlučínské jezero“. It is placed next to the flooding line which is also considered in the project. The building is divided into three operational parts – the hotel, the catering establishments (restaurant) and the area primarily destined for holding conferences and workshops. The hotel is designed to accommodate thirty-two people, the capacity of restaurant is forty-two and conferential area is suitable for forty people at the most. Yacht club is designed as four-storey building with a flat grassed-covered roof. With regard to the foundation conditions, the building is found on piles. The structural part of walls is partly from CLT panels and partly from reinforced concrete which increase the stiffness of the building. The external cladding of the hotel consists of wooden blocks creating ventilated facade, while the rest of the building is rendered.
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