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Furniture
Bocková, Markéta ; Mitura, Vojtěch (referee) ; Tobola, Ondřej (advisor)
Furniture design in the form of a modular shelf system designed to store and display alcohol bottles. The aim of the work is a combination of traditional liquer cabinet and sector display units.
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Vztahy mezi oscilacemi a jejich využití u adaptivní hluboké mozkové stimulace
Lamoš, Martin ; Bočková, Martina ; Daniel, Pavel ; Baláž, Marek ; Chrastina, Jan ; Rektor, Ivan
Hluboká mozková stimulace (DBS) patří vedle dopaminergní léčby k nejvýznamnějším terapeutickým přístupům u Parkinsonovy nemoci (PN). Snaha potlačit některé limitace této terapie vede ke zvýšenému zájmu o přístupy jako je adaptivní DBS (aDBS). Stimulace s uzavřenou smyčkou řízená fluktuacemi výkonu v beta pásmu však nemusí být optimální pro všechny pacienty s PN. S cílem nalézt více senzitivní ukazatel než samotnou beta aktivitu byly analyzovány vztahy mezi jednotlivými oscilacemi v kontextu optimální stimulace subthalamického jádra (STN). Vztah fáze beta rytmu a amplitudy vysokofrekvenčních oscilací se jeví jako vhodný parametr pro cílení stimulace.
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Functional movement disorders: phenotypes, neurobiological markers, pathophysiological mechanisms
Forejtová, Zuzana ; Serranová, Tereza (advisor) ; Kališová, Lucie (referee) ; Bočková, Martina (referee)
Functional Movement Disorders (FMD), also known as conversion, psychogenic, or dissociative motor disorders, are complex and clinically heterogeneous group of diseases. In addition to motor symptoms, FMD are manifested by a number of comorbid non-motor symptoms. Despite the potential reversibility, these disorders still have an unfavourable prognosis and are associated with a low quality of life. Regardless of the growing interest of both clinical and research communities over the last two decades, this issue remains insufficiently understood in many aspects. The aim of the presented studies was to fill some gaps in the knowledge of neurophysiological and clinical correlates in FMD. The first of the presented studies explored the robust neurophysiological phenomenon of prepulse inhibition (PPI) in FMD. The alteration in PPI, along with previous findings of a reduced PPI in other functional syndromes, supported a possible unified pathophysiology across functional neurological and somatic syndromes with implications for diagnostic classification and development of novel biomarkers and treatments. These results are in line with the differentiation FMD from feigned or malingered phenomena. The aim of the second study was to explore the relationship between common motor, non-motor symptoms and...
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Surface phenotype of human carcinoma cancer stem cells (CSC)
Bočková, Marie ; Drbal, Karel (advisor) ; Čermák, Vladimír (referee)
Tumor is composed of a heterogenous mass of cells. Similar to normal healthy organs and tissues, these can be divided into individual cellular subpopulations according to morphology, function and expression patterns. A subpopulation of cells that are able to give rise to all of these cellular lineages is referred to as cancer stem cells (CSC). CSCs have the capabilities of normal stem cells such as the self-renewal and the ability to give rise to a heterogenous population of differentiated cells. Usually, this is the most resistant subpopulation within a tumor, highly non-responsive to therapy. Doing so, they are the cause of residual disease. Characterisation of CSC markers of individual tumor types is beneficial since it enables higher therapy efficacy via targeting this cell population. The -omics approaches to characterisation of the surface proteome bring a broader view into the field when searching for a unique gene signature of specific cancer stem cell types. It has been found that these cells can be identified based on the high expression levels of CD44, CD90 and CD49f. Among other markers, CD47 is an important marker for its immunosuppressive function.
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Study of biomolecular interactions by the method of surface plasmon resonance
Bocková, Markéta ; Homola, Jiří (advisor)
Title: Study of biomolecular interactions by the method of surface plasmon resonance Author: Markéta Bocková Department: Department of Biochemistry, Faculty of Science Supervisor: Prof. Jiří Homola, Ph.D., DSc., Institute of Photonics and Electronics of the Czech Academy of Sciences Abstract: In this diploma work, a surface plasmon resonance (SPR) biosensor technology was exploited to study two different classes of molecular interactions: hybridization of partially complementary oligonucleotides (ONs) and interactions between enzymes and peptides involved in pathogenesis of Alzheimer disease (AD). In particular, the study of interactions between ONs was focused on determining kinetic parameters of the hybridization proces. It was found that the association equilibrium constant decreases with the increasing surface probe density. An SPR biosensor-based method for rapid and sensitive detection of the 17-HSD10 enzyme and its complex with amyloid β (Aβ) peptides was designed and developed. It was demonstrated that the developed method is capable of detecting 17β-HSD10/Aβs complex in real cerebrospinal fluid (CSF) samples and that CSF samples from AD patients exhibited elavated levels of 17β- HSD10/Aβs complex compared to the control groups. The research reported in this thesis resulted in two publications in...
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