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A study of the properties of tablets made of three types of microcrystalline cellulose.
Koreňová, Michaela ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
THE STUDY OF TABLETS' PROPERTIES FROM THREE TYPES OF MICROCRYSTALLINE CELLULOSE SUMMARY The thesis deals with the study of properties of tablets from three type of directly compressible microcrystalline cellulose, namely Microcel® MC-102 SP, Microcel® MC-122 and Microcel® MC-250. The focus of the study was the dependence of tensile strength and disintegration time of the tablets on the compression force, the addition of 0,5% lubricants, namely magnesium stearate and sodium stearyl fumarate (Pruv), and addition of 50% model drugs, namely acetylsalicylic acid and ascorbic acid. The compression forces were used 3, 4 and 5 kN, compacts containing the drugs were compressed only with a force of 5 kN. The strength of tablets from all three types Microcels increased with increasing compression force, the presence of the lubricant resulted in a decrease in the strength. The compacts of Microcel MC-102 SP had similar tensile strenght like the compacts of Microcel MC-122, while the tensile strenght of compacts of Microcel MC-250 was lower. The greatest and smallest decline of tensile strenght due to the lubricant effect was recorded for Microcel MC-122 and Microcel MC-102 SP respectively. The lubricants shortened disintegration time of all Microcels. The longest disintegration time had the tablets of Microcel MC-102...
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A study of the properties of tablets made of directly compressible sorbitol.
Zemanová, Eva ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
A study of the properties of tablets made of directly compressible sorbitol. SUMMARY : The thesis deals with the study of the properties of tablets from two types of directly compressible sorbitol, namely SorbitabTM SD 250 a SorbitabTM SD 500. The focus of the study was the dependence of the tensile strength and disintegration time of the tablets on the compression force, the addition of lubricants magnesium stearate and sodium stearyl fumarate (Pruv ), with concentrations of 0,5% and 1% and a 50% addition of model active ingredients, namely acetylsalicylic acid and ascorbic acid. The compression forces were used 3, 4,5 and 6 kN; tablets containing the drugs were compressed only with a force of 6 kN. The tensile strength of tablets from SorbitabTM SD 500 was higher than of tablets from SorbitabTM SD 250. SorbitabTM SD 500 has demonstrated sensitivity to addition of both lubricants in both concentrations, unlike SorbitabTM SD 250, when the tensile strength of tablets decreased only with the addition of 1% magnesium stearate. The disintegration time of tablets was prolonged by the lubricants, in the case of tablets with SorbitabTM SD 500 most with 1% magnesium stearate at all compression forces. Higher tensile strength was found for tablets containing acetylsalicylic acid and for both drugs with SorbitabTM...
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The study of the properties of tablets made from the mixtures of directly compressible starch and lactitol.
Vajglová, Jana ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
The work studied the mechanical strenght and the disintegration time of tablets prepared by direct compession of mixtures of pregelatinized starch Starch 1500 and directly compresible lactitol LactyTab in proportion 1:1 and 3:1 according to the compression force (12, 16, 20kN), concentration of the lubricant, sodium stearyl fumarate, Pruv, (0, 0,5 and 1%) and addition of model active substance, acetylsalicylic acid (50%). The tablet strenght of the mixtures of Starch 1500 and lactitol in proportions 1:1 and 3:1 rose with the compression force and decreased with increasing concentration of Pruv, there was no significant difference between the strenght of the compacts with 0,5 and 1% of the lubricant for the mixture in proportion 1:1. The blend of Starch 1500 and lactitol 1:1 without any lubricant gave the firmest tablets. Similarly, the mixture in proportion 1:1 with acetylsalicylic acid showed higher strenght of the compacts which decreased with increasing concentration of Pruv. The disintegration time of the compacts rose with the compression force. The hypothesis of longer disintegration time of the tablets with bigger amount of Starch 1500 was confirmed at compression force 12 and 20kN with an exception to blends containing 1% of Pruv. The tablets including acetylsalicylic acid showed longer...
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A study of the properties of tablets from the mixture of directly compressible xylitol and microcrystalline cellulose.
Komínková, Hana ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Název v anglictine: A study of the properties of tablets from the mixture of directly compressible xylitol and microcrystalline cellulose. Summary: The thesis deals with the study of properties of tablets from a mixture of directly compressible xylitol, namely Xylitab® 300, and microcrystalline cellulose, namely Microcel® MC-12, in the ratio of 1:1. (This ratio was arrived at after preceding experiments concerning the strength of tablets made only from Xylitab® 300, and from a mixture of Xylitab® 300 and Microcel® MC-12 in the ratio of 3:1. The strength was insufficient in these cases.) The focus of the study was the dependence of the tensile strength and disintegration time of the tablets on the compression force, the addition of lubricants, namely magnesium stearate and sodium stearyl fumarate (Pruv®), with concentrations of 0.5% and 1%, and a 50% addition of model active ingredients, namely acetylsalicylic acid and ascorbic acid. The compression forces used were 10, 12.5, and 15 kN; tablets containing the drugs were only compressed with a force of 15 kN. Tablets with a weight of 0.5 g and a diameter of 13 mm were compressed using material testing machine T1-FRO 50 TH.A1K Zwick/Roell and they were further subjected to a strength test using Schleuniger Tablet Tester 8M and to a disintegration time test...
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A Study of the Properties of Compacts from silicified microcrystalline celluloses.
Nováková, Petra ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
V práci je studována pevnost tablet v tahu a doba rozpadu výlisků ze silicifikovaných mikrokrystalických celulos, Prosolv SMCC 90 a Prosolv HD 90, v závislosti na lisovací síle, přídavku dvou typů mazadel a dvou léčivých látek. Mazadla byla stearan hořečnatý a stearylfumarát sodný v koncentraci 0,5%, aktivní látky kyselina askorbová a acetylsalicylová v koncentraci 50%. Prosolv SMCC 90 byl lépe lisovatelný než Prosolv HD 90; výlisky měly vyšší pevnost a ta se zvyšovala s lisovací silou. Prosolv HD 90 byl více citlivý na přídavek mazadel a větší pokles pevnosti byl zaznamenán v přítomnosti stearylfumarátu sodného. Vliv mazadel na pevnost tablet v přítomnosti léčivých látek nebyla stejná. Doba rozpadu výlisků z Prosolvu HD 90 bez i s mazadly byla kratší než z Prosolvu SMCC 90 a zvyšovala se s rostoucí lisovací silou. Doba rozpadu se prodloužila přídavkem mazadel a významně byla zkrácena přídavkem léčivých látek. Výlisky s kyselinou askorbovou měly kratší dobu rozpadu než s kyselinou acetylsalicylovou a doba rozpadu nebyla výrazně ovlivněna přítomností mazadel.
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Study of bioadhezive polymers
Kuntová, Darina ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
DIPLOMA THESIS 2006 DARINA KUNTOVÁ The aim of this graduation theses was to study the adhesiveness of oligoesters branched using mannitol or dipentaerythritol and plasticized 20% of ethyl pyruvate or 30% trietyl citrate under various testing conditions using Material testing machine Zwick/Roel T1-FR050TH.A1K. The maximum force (Fmax) required to detaching the polymer systems from substrate was measured for determination of adhesiveness of oligoesters. The detachmen speed of 10 mm/min, 100 mm/min and 200 mm/min, consolidation time of 5s or 10s and contact force 10N or 20 N were tested. It was found that Fmax of branched oligoesters was significantly higher in comparison with cellulose derivatives, acrylate derivatives or gelatine. The increase of the maximal adhesive force is due to the growing consolidation force, the contact time and sample detachment velocity.
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A comparison of the properties of tablets from silicified microcrystalline celluloses of different particle size.
Nováková, Petra ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
In the work is studied mechanical strength and disintegration time of tablets prepared by direct compression of the two form silicified microcrystalline celluloses - Prosolv SMCC 50 and Prosolv SMCC 90 according to the compression force (3; 3,5; 4kN), addition of lubricants (magnesium stearate, Pruv) and addition of model active substances (acetylsalicylic acid, ascorbic acid). Studied co-processed filler-binders differ by the size of elements. Used concentration of lubricants was 0,5 %, of model active substances 50 %. Tablet strenght and the disintegration time rise with the increasing compression force. The work confirms the low impact of the lubricants on the tablet strenght from microcrystalline celluloses (especially Prosolv SMCC 50). Prosolv SMCC 50 gives firmer tablets with longer disintegration time. The disintegration time of all of the tableting blends is increased by adding of lubricants as well, higher negative impact has magnesium stearate. The presence of model active substances decreases the strength of the tablets and accelerates the disintegration time of all of the tested compounds, in the mixtures with active substances was not applied negative impact of lubricats on the disintegration time (except of Prosolv SMCC 50 in mixture with ascorbic acid - the disintegration time was not...
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A study of the properties of tablets from the mixtures of α-lactose monohydrate and of two types of microcrystalline celluloses.
Páleník, Lukáš ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
The paper deals with the study of the properties of tablets from the mixtures of the dry binders composed from 75% α- lactose monohydrate (Tablettose® 100) and 25 % microcrystalline celulose or microcrystalline celulose with 2% of colloidal silicon dioxide (Prosolv SMCC® ). The properties under study included the tensile strength and disintegration time in dependence on compression force, addition of two concentration of the lubricant magnesium stearate and a 50% addition of the active ingredient ascorbic acid. The compression forces were 23, 25, 27 kN, in the case of the tableting material with the active ingredient only 25 kN. The compacts from the mixture of Tablettose 100 and Prosolv SMCC 90 were of higher strength and the effect of lubricants wasn't so expressive like at mixtures with microcrystalline celulose only. Disintegratiion time was prolonged with the increasing of the concentration of magnesium stearate, more in the case of microcrystalline celulose in the mixture only. In the presence of ascorbic acid, the strength of tablets was decreased, the difference in the values of strength of tablets with silicified microcrystalline celulose and microcrystalline celulose wasn't. Ascorbic acid shorted the disintegration time too and more in the case of the mixture with Prosolv SMCC 90.
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A study of the properties of tablets from coprocessed dry binder based on directly compressible starch and lactose.
Moučková, Eva ; Mužíková, Jitka (advisor) ; Řehula, Milan (referee)
The paper deals with the study of the properties of tablets from coprocessed dry binder StarLac. The properties under study included the tensile strength and disintegration time in dependence on compression force, addition of two lubricants (magnesii stearas, sodium stearylfumarate) in two concentrations (0,4. 0,8%) and a 50% addition of the active ingredient ascorbic acid. The compression forces were 15, 16, 17 kN, in the case of the tableting material with the active ingredient only 16 kN. The addition of magnesii stearas in a concentration of 0,4% increased the tensile strength, but in a concentration of 0,8% didn't. The same result is in the case of sodium stearyl fumarate for compression force 17 kN. The addition of lubricants increased the disintegration time of tablets, less in the case of Pruv. The addition of ascorbic acid decreased the tensile strength of tablets, the disintegration time was shorten. StarLac without and with magnesii stearas too offers the tablets with higher tensile strength and with shorter disintegration time then the physical mixture of Starch 1500 and Pharmatose DCL 15.
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