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The study of polymorphism and optimization of active pharmaceutical ingredients crystallisation
Novák, David ; Ing.Ladislav Cvak, Ph.D. (referee) ; Ing.Roman Gabriel (advisor)
Active pharmaceutical ingredients (APIs) are frequently delivered to the patient in the solid-state as part of an approved dosage form (tablets, capsules, etc.). Understanding and controlling the solid-state chemistry of APIs is therefore an important aspect of the drug development process. APIs can exist in a variety of distinct solid forms, including polymorphs, solvates, hydrates, co-crystals and amorphous solids. Each form displays unique physicochemical properties that can profoundly influence the bioavailability, manufacturability, stability and other performance characteristics of the drug. Most APIs are purified and isolated by crystallisation from an appropriate solvent during the final step in synthetic process. The main objective of a crystallisation process is to produce crystals with desired properties such as particle size distribution (PSD), shape and purity. All pharmaceutical dosage forms must be produced in uniform units, and good content of uniformity is only possible when the size of the active component is carefully controlled. For on-line control of crystallisations of Quetiapine Fumarate to achieve desired PSD and no changed physicochemical purity was used the Lasentec Focus Beam Reflectance Measurement (FBRM) system.
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Creation of Foreign Branch of the Company
Novák, Ladislav ; Sedlář, Roman (referee) ; Koráb, Vojtěch (advisor)
The topic of the thesis is the comprehensive proposal for establishing foreign branch of the company in the Baltics with a distribution network across the countries of the region. The theoretical part is focused on basic information regarding the legal requirements in the countries concerned. Practical part deals with the specific formation of a subsidiary and commissioning.
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Spectral charakteristic of Ion area for different type of ionisors
Novák, Roman ; Svoboda, Vít (referee) ; Buřival, Zdeněk (advisor)
This work deals with issues of explanations and describing of a whole kind of probléme, which appear duiring a generations and measurings of a anionts. I would like to explain and warn for different factors why we should continue with measuring and inventing in this thema. Understanding of a anionts behavior and practice measuring of a ionts area is the most important part of my work, to correctly analyse iont area probléme, or to suggest suitable solution.
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Utilization of Financial Analysis as a Tool for Investment Decisions
Málek, Jiří ; Novák, Jaromír (referee) ; Ptáček, Roman (advisor)
This diploma thesis on the topic "Use of financial analysis as an instrument of investment decision-making" processes the financial evaluation of the economy and the effectiveness of selected investment decisions in the past years using methods of financial analysis. For this purpose, I chose the monitored period from 2012 to 2018. In the first part of the thesis, attention is paid to the evaluation of performance and financial sustainability in terms of implemented and planned investments of the theoretical base. The methods and analyzes used also include the methodology of their calculation. The second part deals with the individual indicators applied to Škoda Auto a.s., based in Mladá Boleslav a subsidiary of the Volkswagen Group. In addition, this section addresses the approach and decision making of the management of the company on investment projects that have already been planned or are planned in the near future, and recommendations are proposed for improving.
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Using lead-acid accumulators in hybrid electric vehicle regime
Hejdiš, Roman ; Novák, Vítězslav (referee) ; Bača, Petr (advisor)
The master´s thesis discuss characteristics of hybrid electric vehicles and lead-acid accumulators applied in car industry. It compares classic and alternative drive in cars, descibes classification of hybrid drives and its characteristics. Further work disscus lead-acid accumulators which focuses on VRLA accumulators applied in hybrid electric cars. Practical part contains a construction description of negative electrode and experiment, which studied influence of various amount addition of carbon on attributes of these electrodes.
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Proposal for Changes of Motivational System of a Selected Company
Frydrych, Lukáš ; Novák,, Roman (referee) ; Konečná, Zdeňka (advisor)
The bachelor thesis deals with the motivation system of Oscom Trading s.r.o. The main goal of the thesis is to propose a change in the motivation system of the company, which will lead to an increase in employee satisfaction and their retention in the company. The theoretical part of the thesis focuses mainly on the topics of HR, motivation and remuneration of employees. The practical part deals with information about the company and analysis of the current state of motivation system in the company. The research is carried out using the questionnaire method and interviews with employees. The design part contains a proposal for changes in the company motivation system.
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ICT Selection
Dvořáček, Roman ; Novák, Lukáš (referee) ; Koch, Miloš (advisor)
This bachelor thesis is focused on selecting the most suitable information system for selected company. The first part of the thesis contains a theoretical basis. The second part is focused on the analysis of the current state. The output of the final part of the thesis is the determination of the requirements for the new information systém. Its subsequent selection and the design of the implementation process.
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Image Transformations
Novák, Radim ; Juránek, Roman (referee) ; Venera, Jiří (advisor)
The main goal of this thesis is to introduce two fundamental geometric transformations in 2D space - by changing the resolution together with related image resampling and image rotation. Also brightness interpolation, technique of mapping and other problems related to the topic are explained there, i.e. Fourier transformations, problem with aliasing and technique of aliasing suppression.
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Powertrain of a modern hybrid vehicles
Novák, Štěpán ; Zajac, Roman (referee) ; Otipka, Václav (advisor)
This bachelor’s thesis is about the drivetrain in modern hybrid vehicles. It describes the function of a hybrid drivetrain and divides it according to structure, degree of hybridization and placement of the electric motor. It characterizes the design solution of the main components of a hybrid drivetrain. It focuses on the powertrain of selected hybrid vehicles and describes the emissions issue. The conclusion consists of evaluation of the hybrid drivetrain and its vision for the future.
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Corrency as a new form of transaction system
Novák, Filip ; Vybíral, Roman (advisor) ; Kotáb, Petr (referee)
Corrency as a new form of transaction system Abstract The master's thesis in a comprehensive form presents a completely new transactional system called Corrency, which stands out from the existing solutions with its specific characteristics. The aim of the master's thesis is to describe this system, present it in the light of financial law, and analyze its potential applications in related legal fields. Corrency is a transactional system currently primarily used for distributing financial resources from public institutions to citizens, with the future possibility of expanding its use to the private sector. It is transparent, simple, fast, inexpensive, and fully digital. The issuer, who deposits funds into the system, obtains unique data on their movement and can target their money both to suitable primary recipients, typically citizens, and to specific market segments that genuinely require such assistance. Corrency operates with a unit of account called Corrent, which this thesis examines not only from a legal perspective but also in the context of economics and finance. Another objective of the thesis is to provide the reader with the broadest legal context and to construct an analysis of the issues surrounding this system from the ground up, starting from the comparison of Corrents with institutions such...
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