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Attachment, communication styles and relationship adjustment in long-term romantic partners
Fišerová, Anna ; Lindová, Jitka (advisor) ; Bártová, Klára (referee)
Constructive management of relationship conflicts, which may be conditioned by the interaction of both romantic partners, is a key factor for mutual satisfaction. Therefore, the main aim of this thesis was to find out a mediating role of conflict communication styles in long-term heterosexual couples. For the Practical part of the thesis was chosen a quantitative research, including data from 76 long-term heterosexual couples between 18 - 40 years of age. Attachment dimensions were measured by The Close Relationship Experience - Revised (ECR-R-16), relationship adjustment by The Dyadic Adjustment Scale (DAS), and six conflict communication styles (compromising, dominant, separating, submissive, avoidant and reactive) by The Romantic Partner Conflict Scale (RPCS). The effect of conflict communication styles as mediators seems to be predicted by attachment and gender. In men, the mediating function of communication styles between attachment and relationship adjustment was confirmed for reactive and avoidant style, in women for reactive and compromising. The mediating effect of communication styles was not significant for partners' relationship adjustment. Key words: attachment, romantic relationships, communication styles, conflict communication
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Anticancer immunity in animal models and experimental immunotherapy with glycodendrimers specific for the lectin-like receptor NKR-P1
Vannucci, Luca Ernesto ; Fišerová, Anna (advisor) ; Bubeník, Jan (referee) ; Apte, Ron Nathan (referee)
5 SUMMARY Anticancer immunity is a complex network in which innate immunity play an critical role. The immune system can control the onset of tumors by recognizing the changed phenotype of the transformed cells as a non-self phenotype. The active control against cells not presenting self characters is defined by the paradigm of immune surveillance. In recent years, various studies have shown that the immune response against transformed cells start as a localized acute inflammatory response. The cooperation of natural-killer cells (NK) and phagocytes attracted by so-called "danger signals" (pro-inflammatory molecules and chemo-attractants delivered by stressed cells) can lead to total ablation of the harmful cell clone. If the intervention is not completely efficient, immunoediting of the tumor can follow with stimulation of chronic inflammatory responses, mainly mediated by macrophages. The systemic immunity attempt to terminate the uncontrolled inflammation stimulates the intervention of regulatory T lymphocytes and the shift from an antitumor cytotoxic Th1 response to a Th2 inhibitory response. This regulatory mechanism paradoxically assists the tumor development. All the described events needs the interplay and cooperation of both tumor cells and host cells and stromal elements, that altogether form the...
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Urban study of development area Vítkovice - Moravská Ostrava
Fišerová, Anna ; Klement, Miloš (referee) ; Sátora, Josef (advisor)
'The inspiration behind this project is the new urbanist idea which combines residential development with green spaces for leisure and sport as well as mixed use commercial areas and storage. The layout of the area is a grid formed by 100m squared plots with residential houses with personal yards. These plots are grouped as complexes and between each complex is a communal green space. On the outside of the inner grid, there are mixed use apartment buildings and a high commercial floor. The square is dominated by a smaller multi-purpose building with a fluid outside space in which community events can be organized. Diagonally connected to the square is a park with a playground and an area with patio seating in addition to three villa houses. The park leads to the river embankment, into which tiered seating will be created. Around the hotel, there is another park with a multi-generational playground. In the northern part is located hotel renovated from the original industrial buildings with added ground floor restaurant area. Around hotel there is a park with green space and multi-generational playground. The terrace houses are located in the northeastern part of the complex and feature an attractive riverside view. Row houses line the the main road and are buffered from street noise by a line of trees. Typology and placement of other, separate houses is inspired by colonies of worker-houses eg. Baťa houses in Zlín. In between each ground these is no fence and are only separated a slight depression in the green.
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Material culture of residencies of the Krakovský z Kolovrat family between 1750 and 1850
FIŠEROVÁ, Anna
The presented thesis deals with material culture of residencies of the Krakovský z Kolovrat family (Kolowrat-Krakowsky) between 1750 and 1850. Its goal is to describe inner space and material equipment of a few castle buildings which were owned by the Brezno branch of Krakovský z Kolovrat family in the given time. The author used a number of preserved inventories and bills from the second half of 18th and first half of 19th century. She tried to identify a purpose of particular buildings and their role in a resident network of the Krakovský z Kolovrat family. The thesis analyses changing fashion trends in the field of furniture, dining and lifestyle. A subject of interest is not only description of particular spaces but also a symbolic meaning of decoration and objects of everyday and non-everyday need which had surrounded privileged individuals in their residencies. Based on that the author aims to penetrate a thought world of noblemen and outline their value charts.
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Velvet Revolution: A Gender Perspective
Fišerová, Anna ; Gelnarová, Jitka (advisor) ; Franěk, Jakub (referee)
This bachelor's thesis seeks to introduce a new perspective on one of the most important episodes in the era of modern Czech history - the Velvet Revolution - and it looks at its events through "gender lens". The events happening in the last two months of the year 1989 led to the fall of the communist regime in the former Czechoslovakia. This development would not be possible without the men and women active in then "revolutionary structures" such as Civic Forum or the students movement. It is the active participation of women that this thesis concerns itself with. The aim is not only to find out whether women engaged to the same extent as men but also if it is possible to typify their activities. It also tries to discover whether gender stereotypes played some role in the process of eventual typification - the question is if there was a division of labour based on gender within the revolutionary structures. In the theoretical part, the thesis operates with the concepts of gender and gender stereotypes and the ideology of separate spheres. In the empirical part, it introduces the outcomes of analysis of my own qualitative research - personal half-structured interviews conducted with active women participants of the Velvet Revolution.
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NK cell involvement in the pathogenesis of autoimmune arthritis
Richter, Jan ; Fišerová, Anna (advisor) ; Hromadníková, Ilona (referee) ; Turánek, Jaroslav (referee)
Rheumatoid arthritis (RA) is a worldwide problem representing one of the most prevalent autoimmune diseases in the world. Despite the commonness of the disea- se, its pathogenesis has not been fully described. Immune cells ranging from antigen- presenting cells to T, B and NK cells playing various roles participate in the rheumatic process. In this work we concentrated on NK cells expressing a repertoire of activating and inhibitory receptors which influence their function in health and disease. We focused on the analysis of NK cell function and described its possible modulation by rheumatic autoantigens and multivalent glycodendrimers bearing 4 (GN4C) or 8 (GN8P) N-acetyl glucosamine moieties. The effect on NK cells and the glycosylation pathways was further studied in vitro. Finally, an in vivo study was performed on an animal model of RA - col- lagen-induced arthritis (CIA) to assess the effect of the compounds on clinical develop- ment of the disease and selected immune parameters. Comparison of NK cell cytotoxicity in patients suffering from RA, other inflam- matory diseases and healthy donors showed its impairment particularly in RA patients. Peripheral blood NK cells reacted to GN8P glycoconjugate by inhibition of their effector function in CD161 high-expressing samples. The MGAT5...
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NK cells and their receptors in immune regulation - possible targets for immunomodulation
Svoboda, Jan ; Fišerová, Anna (advisor) ; Pěknicová, Jana (referee) ; Kročová, Zuzana (referee)
(english) Natural Killers - NK cells play an important role in immune surveilance and regulation either by direct cytotoxicity towards infected, transformed or otherwise damaged cells, or by production of cytokines and chemokines. The resulting response of NK cells is given by the sum of stimulating and inhibiting signals, tranduced by a wide array of receptors. Killer Ig-like receptors KIR2DL4 and LILRB1, which recognize self HLA-G molecules in pregnancy, as well as NKR-P1 receptors, which differ in the number of isotypes, are species-dependent and reduced during phylogenesis. NKG2D, reacting to stress-inducible proteins, and adenosine receptors (AR), which supress the inflamatory reaction, remain evolutionary conserved. The aim of this work was to study the involvement of NK cells and their receptors in several immune disorders and in various species, to provide new insights into their function and posisible immune modulation. We have shown here, that the choice of species in the study of NK cell effector functions may be crucial in some cases. The reaction to glycans, using synthetic GlcNAc-terminated glycomimetics GN8P, exerted opposing effects on NK cell function in humans and C57Bl/6 mice. In humans, the glycomimetic decreased cytotoxic activity of high NKR-P1A expressing NK cells, while in...
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