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Synthesis and Study of Properties of Aza-analogues of Phthalocyanines
Nováková, Veronika ; Zimčík, Petr (advisor) ; Kuča, Kamil (referee) ; Kubát, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Pharmaceutical Chemistry and Drug Control Candidate Mgr. Veronika Nováková Supervisor doc. PharmDr. Petr Zimčík, Ph.D. Title of Doctoral Thesis Synthesis and study of properties of aza-analogues of phthalocyanines Phthalocyanines (Pc) and their azaanalogues azaphthalocyanines (Azapc) are planar macrocyclic compounds with significant absorption band at 620-720 nm finding application in the areas such as photodynamic therapy, chemical catalysis and solar cells. Photophysical (fluorescence) and photochemical (singlet oxygen production) parameters are important in above mentioned applications. Peripheral substituents of Pc/AzaPc play key role in this case. Alkylsulfanyl and alkyloxy derivatives exerted high fluorescence quantum yields (ΦF) as well as quantum yields of singlet oxygen (ΦΔ). On the other hand, alkylamino substitution led to almost zero values of both ΦF and Φ∆. These derivatives have recently found new application as dark quenchers in DNA hybridization probes. The first part of this thesis demonstrated that intramolecular charge transfer (ICT) is responsible for zero values of quantum yields of alkylamino AzaPc and that the lone electron pair of peripheral nitrogen is a donor for ICT in AzaPc....
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Design, synthesis and evaluation of heterocyclic compounds with potential antimicrobial activity VI
Abdalrahman, Nechirwan ; Zitko, Jan (advisor) ; Nováková, Veronika (referee)
(In English) Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Author: Nechirwan Abdalrahman Supervisor: Assoc. Prof. PharmDr. Jan Zitko, Ph.D. Title: Design, synthesis, and evaluation of heterocyclic compounds with potential antimicrobial activity VI Despite the existence of a well-established treatment regimens, tuberculosis (TB) continues to be the most leading cause of death by a single microorganism, as reported by WHO. One of the reasons behind treatment failure in completely eradicating this infection is drug resistance. Novel 3-(phenylureido)pyrazine-2-carboxamide derivatives, refer to figure below, were synthesized by reacting 3-chloropyrazine-2-carboxamide with ammonia to produce 3- aminopyrazine-2-carboxamide as an intermediate building block, followed by reacting with various substituted phenyl isocyanates using a microwave reactor. The synthesized compounds were evaluated for in vitro activity against various mycobacterial strains, where most active ones among them showed moderate to low activities; 4-tertiary butyl (MIC 62.5 µg/mL), 4-NO2 (MIC 62.5 µg/mL), 4-Bromo (MIC 250 µg/mL), 4-Cl (MIC 250 µg/mL), 2-F (MIC 250 µg/mL), and non-substituted (MIC 500 µg/mL). As a complementary study in silico, the synthesized...
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Role of DAAD in German Foreign Cultural Policy after 1990
Nováková, Veronika ; Emler, David (advisor) ; Lizcová, Zuzana (referee)
The thesis examines in detail the role of the German Academic Exchange Service (DAAD) in German foreign cultural policy. It traces the development of the DAAD in response to political and social changes and analyses it in two key periods: 1990-1999 and 2000-2022. The year 2000, when the new concept of German foreign cultural policy was presented, is considered a turning point that influenced the future direction of Germany. The study examines how the DAAD promotes cultural and academic exchange between Germany and other countries, including its focus on initiatives in Czechia. Through historical perspectives and the gradual establishment of DAAD programs, the thesis seeks to provide the transformation of this organization and highlight its key importance in promoting international mobility of students and scholars. It also analyses the challenges facing the organisation, including the declining interest in learning German as a foreign language, the effects of the coronavirus pandemic and the Russian invasion of Ukraine. The thesis therefore focuses on the organisation's adaptation to these new conditions and describes the measures the organisation took to mitigate their impact. It thus seeks to show the role that the DAAD has played in the expansion of Germany's 'soft power' in the context of its...
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Technical standards for quality.
Nováková, Veronika ; Koška, Petr (referee) ; Fiala, Alois (advisor)
This thesis deals with the question of whether the technical standards have an impact on quality. We understand quality as a degree of compliance of requirements of a set of inherent features. Inherent feature means its own internal character of the object, whose quality is dealt. Quality and standards passed a long development, both from a point of law, as well as history, which began as early as in the old Mesopotamia by reference in Chammurapi Code. Since then, the quality changed its definition for several times, but the meaning of quality remains the same. It is necessary to mention the initiator of the quality who contributed by their work to its development, such as Prof. RNDr. František Egermayer, DrSc., who was the most significant initiator of modern understanding of quality in our country, then it is Dr. Joseph M. Juran, renowned author and "father" of modern quality management, also we must not forget William Edwards Deming, an American statesman and professor who is the most known of his work in Japan, and not least, world-famous personality Agnes Waddell, and other prominent personalities in this field. Today, quality control and normalizing ensure the main government authorities, such as Ministry of Industry and Trade of CR, which also ensures the management of other government bodies (ÚNMZ, ČMI, ČIA, see Chapter 6). The very Ministry of Industry and Trade may encharge a corporate entity to creation assurance and issuing Czech technical standards, their amendments and repeal. This assignment is non-transferable. As long as this assignment is valid, no other corporate entity must be encharged for this activity. There is no legal claim for this assignment. The costs of the creation of the Czech technical standards are covered by a person who requires processing. The costs of the creation of standards, notably the Czech technical standards transposing European standards, prepared pursuant to the request of the ministries or other central government departments and the costs associated with membership in international and European standardization organizations are paid by the State. In creation and issuing the Czech technical standards, their changes and cancellation must be provided the conditions laid down in the decision to assignment, as set out in Chapter 3.
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Marketing Research of Customer Satisfaction
Nováková, Veronika ; Kramolišová, Eva (referee) ; Šimberová, Iveta (advisor)
The thesis deals with a survey of customer´s satisfaction in the company KABESTAV. The theoretic part describes the problematics of marketing research and a questionnaire as a tool for collecting information. The practical part is describing company; where, in which way and with what results was the costumer satisfaction survey made. These indicators are shown in tables and graphs. Further the thesis continues by final evaluation of the costumer satisfaction survey and finishes by improvement proposals chapter.
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Proposal and Valuation of Investment Project
Nováková, Veronika ; Kocourková, Gabriela (referee) ; Vítková, Eva (advisor)
The Master thesis contents a propsal and evaluation of an investment project. The master thesis is divided into a theoretical and a practical part. The theoretical part describes the investment project together with an investment plan. The investment plan is further developed in more details and deals with a market analysis, a marketing plan, a size and a location of a company, its human resources, an operating plan, a financial plan, a financial analysis and above all with methods of assessment of investment projects. The practical part focues on a specific investment project proposal and its subsequent evaluation. The proposal offers a marketing research with a financial plan and financial analysis. The assessment of the project is carried out by using different methods of assessment of investment projects.
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Optimization of production process
Nováková, Veronika ; Krásová, Anna (referee) ; Fiala, Alois (advisor)
The aims of this dissertation are to analyze the current state of process control, to identify the product range in selected organization and to design the process planning methodology to ensure an optimal implementation. Optimization is understood as costs minimization while keeping an acceptable continuity of supply. The dissertation contains a description of technological and non-manufacturing processes of brick products, as well as the summary and description of the basic tools of quality management.
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The History of Yersinia Pestis in Europe from the Perspective of Ancient DNA
Nováková, Veronika ; Ehler, Edvard (advisor) ; Vojíř, Karel (referee)
je gramnegativní bakterie, která byla na konci devatenáctého století odhalena jako původce moru. je blízce příbuzná , od níž se liší přítomností určitých virulentních faktorů. Právě virulentní faktory umožňují efektivní přežití hmyzích vektoru, kterým je blecha. Blecha poté zajišťuje úspěšný přenos bakterie na obratlovce, což je nejčastěji hlodavec, případně člověk. Bakterie je geneticky vybavena tak, aby unikla imunitnímu systému. Během lidské historie proběhly tři morové pandemie, Justiniánský mor, Černá smrt a moderní pandemie, u všech z nich byla pomocí aDNA z kosterních pozůstatků potvrzena přítomnost . Mor způ době bronzové. Sekvenace aDNA a zdokonalování molekulárních metod při studiu historických pandemií se jeví jako vhodná strategie pro pochopení možných budoucích pandemií. Pomocí aDNA lze zjistit nejen fylogenezi patogenů, ale je možné i sledovat změny genofondu populace napříč historií a jak v migracemi, tak i možnými změnami způsobenými samotným KLÍČOVÁ SLOVA mor, bakterie, migrace, populace, mikrobiologie, starodávná DNA
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Synthesis of Alkaloid-like Compounds with Quaternary Carbon Centers
Jansa, Petr ; Matoušová, Eliška (advisor) ; Baszczyňski, Ondřej (referee) ; Nováková, Veronika (referee)
Synthesis inspired by natural products has a long tradition in drug development. Because the structure of bioactive natural compounds is often very complex, preparation of their derivatives requires the development of specific synthetic procedures. This thesis focuses on derivatives of certain alkaloids from the Amaryllidaceae plant family as examples of such compounds. The thesis explores the possibilities of preparing polycyclic compounds that contain the structural motif present in tazettine, crinine, or mesembrine-type alkaloids. This motif includes a quaternary all-carbon center, for which a method involving a tandem cyclization/Suzuki coupling reaction and a halocarbocyclization was developed and optimized in this work. The scope of these reactions was studied, and variously substituted products containing oxygen and nitrogen cycles were prepared. Furthermore, methods for the synthesis of N-alkylated derivatives, dehydrohalogenation to form a double bond, or various mainly oxidative modifications of the cycle adjacent to the aromatic ring were developed. After developing a method for the preparation of enantiomerically enriched starting material, an asymmetric version of the entire synthesis was successfully performed. Finally, biological properties of selected compounds were studied. Some...
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Design, synthesis and evaluation of heterocyclic compounds with potential antimicrobial activity VI
Abdalrahman, Nechirwan Taimur ; Zitko, Jan (advisor) ; Nováková, Veronika (referee)
(In English) Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Author: Nechirwan Abdalrahman Supervisor: Assoc. Prof. PharmDr. Jan Zitko, Ph.D. Title: Design, synthesis, and evaluation of heterocyclic compounds with potential antimicrobial activity VI Despite the existence of a well-established treatment regimens, tuberculosis (TB) continues to be the most leading cause of death by a single microorganism, as reported by WHO. One of the reasons behind treatment failure in completely eradicating this infection is drug resistance. Novel 3-(phenylureido)pyrazine-2-carboxamide derivatives, refer to figure below, were synthesized by reacting 3-chloropyrazine-2-carboxamide with ammonia to produce 3- aminopyrazine-2-carboxamide as an intermediate building block, followed by reacting with various substituted phenyl isocyanates using a microwave reactor. The synthesized compounds were evaluated for in vitro activity against various mycobacterial strains, where most active ones among them showed moderate to low activities; 4-tertiary butyl (MIC 62.5 µg/mL), 4-NO2 (MIC 62.5 µg/mL), 4-Bromo (MIC 250 µg/mL), 4-Cl (MIC 250 µg/mL), 2-F (MIC 250 µg/mL), and non-substituted (MIC 500 µg/mL). As a complementary study in silico, the synthesized...
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