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Public transport connection of the new Brno Railway station
Bartoň, Daniel ; Pavlíček, Jan (referee) ; Holcner, Petr (advisor)
The diploma thesis deals with the issue of the availability of the new Main Railway Station in Brno, its transfer to other location, modernization or reconstruction and its connection to the public transport system. It focuses in particular on the public transport in Brno affected by the transfer of the railway station and on regional passenger railway transport in the vicinity of Brno. It describes, evaluates and assesses various variants of the transfer of the new railway station in terms of time savings for passengers traveling through the Main Railway Station and their source or destination of travel is in Brno or in the vicinity of Brno. The most suitable appears variant B - the transfer of the station under Petrov.
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Design of a simulator module for analysis of friction and wear of teeth during cleaning
Snopek, Lukáš ; Streďanská, Alexandra (referee) ; Vrbka, Martin (advisor)
This thesis focuses on the design of a module for the tribological simulator Bruker UMT TriboLab, which will be used in research in the field of analysis of wear of hard dental tissues and filling materials due to tooth cleaning. The aim of this work was the design of experimental conditions, module construction, creation of drawing documentation, production and subsequent implementation of a validation experiment. The conditions of the experiment were determined on the basis of research and to create an optimal design solution, prototypes were continuously produced using the 3D printing method. Finally, two toothbrush fixtures and two dental filling sample fixtures were made based on the drawing documentation. Subsequent assembly of the fixtures and the implementation of the experiment on the tribometer verified their functionality, which makes it possible to declare all the goals successfully met. Now these fixtures will be part of several research tasks in the field of oral biotribology.
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Preliminary aerodynamic analysis of remotely controlled model with jet propulsion
Novák, Ondřej ; Zikmund, Pavel (referee) ; Popela, Robert (advisor)
This bachelor´s thesis deals with aerodynamic analysis of unmanned aircraft and subsequent changes to design of wing, its position and wing-fuselage junction. In this work emphasis is laid on flow separation, its interaction with other flow structures and its influence on aerodynamic properties. The goal of these changes to the aircraft is ensuring sufficient stability and controllability in low as well as high angle of attack flight. AVL, XFLR5 and CFD methods were used in the thesis. In case of inaccuracy of CFD calculation, two backup wing related modifications were prepared.
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Positive displacement pump design
Poprac, Martin ; Sluše, Jan (referee) ; Klas, Roman (advisor)
This bachelor work is about basic types of positive displacement pumps, focused on their design, advantages and disadvantages and their applications. In the second part of the work we are focused on the possibilities of reducing noise levels of some types of positive displacement pumps. The whole work consists of many pictures and diagrams for the better understanding.
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Computational Modeling of Gear Mesh Engagement Dynamics by MBS Approach
Pykal, Vojtěch ; Řehák, Kamil (referee) ; Prokop, Aleš (advisor)
This master’s thesis is focused on the compilation of a computational modelling of gear mesh engagement dynamics of a spur gear by MBS approach. The user input is the specific geometry of gears, the operating speed, and the load torque. The output are the forces in the gear engagement and the reaction of the forces in the wheel bearings depending on the change in the stiffness of the gear due to the changing number of teeth in the engagement and the change in the axial distance. This model is characterized by a fast and relatively accurate calculation in the time domain. This means that it can react to changes in parameters during simulation such as axial distance, speed, and torque.
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Knowledge of lower secondary selected school pupils about dental hygiene
Prchalová, Kateřina ; Thorovská, Alena (advisor) ; Zvírotský, Michal (referee)
The bachelor's thesis deals with the knowledge of lower secondary students of a selected school about dental hygiene. The theoretical part is focused mainly on the prevention of dental caries and dental aids. There is also described the anatomy of the oral cavity, the morphology of the teeth, the structure of the teeth, the structure of the teeth as a whole and the most common diseases caused by insufficient or incorrectly performed oral hygiene. The practical part is mediated by a questionnaire survey, which took place in the 9th grade of primary school in Havlíčkův Brod. The aim was to find out what knowledge the students have about dental hygiene, dental aids and teeth in relation to the subjects of health education and natural history. The second partial goal was to find out what is their most common source of information about dental hygiene. The results of the questionnaire survey showed that the pupils of this school have a satisfactory knowledge of dental hygiene, but the anatomical knowledge about the teeth and the problems caused by the insufficient hygiene of the oral cavity is less satisfactory. It was found that pupils most often obtain information from parents, dentists or dental hygienists. On the contrary, they get the least information from advertisements and influencers. At least...
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Morphological variability of the incisor in mutant mice
Lochovská, Kateřina ; Hovořáková, Mária (advisor) ; Churavá, Svatava (referee)
Myš je nejfrekventovaněji používaným experimentálním modelovým organismem pro studium vývoje zubů. Myší funkční dentice obsahuje jeden řezák oddělený od tří molárů dlouhou bezzubou diastemou v každém čelistním kvadrantu. Cílem této práce bylo shrnout poznatky o myší dentici a jejím vývoji se zaměřením na myší řezáky a jejich patologie. Myší řezák je díky svým vlastnostem jedinečným zubem. Charakteristickou vlastností hlodavců jsou právě kontinuálně rostoucí řezáky. Tyto řezáky jsou pokryté sklovinou pouze na labiální straně. Lingvální povrch je tvořen pouze dentinem. Toto je spojeno s asymetrickou abrazí. Nicméně je také častým cílem mutací, ať už v podobě delece nebo jiné modifikace genů. Tyto mutace dentálních signálních drah jsou studovány na mutantních myších jako jsou například Tabby myši, Sprouty nebo Small eye (Sey) mutantní myši a mnoho dalších. Některé mutace jsou homologní k lidským onemocněním. Například X-vázaný tabby (Ta) syndrom u myší je považován za homolog hypohidrotické ektodermální dysplásie (HED) u lidí. Tato mutace napadá velikost řezáku, jeho tvar a pozici stejně jako cytodiferenciaci. Dále se může objevit hypodoncie, anodoncie nebo nějaké morfologické změny napadající ostatní existující zuby. Abnormality v počtu, velikosti a tvaru zubu byly dobře zdokumentovány v lidské...
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Ancient-DNA analysis of teeth and skeletal remains with utilization of miniSTR loci.
Kvítková, Dana ; Brouček, Jaroslav (advisor) ; Dobisíková, Miluše (referee)
During the last twenty years, immense progress occurred in the area of analysis of DNA extracted from historical material. Considering the common level of preservation of tissue material, this analysis is usually executed on samples procured from bones and teeth. The analysis of soft mummified tissue is possible only in rare cases. Limiting factor of these analyses is a high degree of degradation and small amount of DNA extractable from this kind of material. First researches concentrated only on short sections of mainly mitochondrial DNA. Today, the analysis of the complete mitochondrial genome of both contemporary and extinct organisms was made possible. In case of analyses conducted on human remains, sections of nuclear DNA are far more valuable, because they can reveal information including not only subject's sex, but also possible kinship between subjects found e.g. in the same grave. Fundamental component of the whole analysis is the process of extracting DNA from cells. Probably every laboratory working with historical DNA uses a differently modified extract protocol. The main requirement for methods of extraction is to secure enough DNA with such a level of purity that would allow its use for following steps of the analysis. Taking in consideration high fragmentation of DNA, it is necessary...
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The signs of odontogenesis externally to the prospective functional dentition in the experimental model
Fábik, Jaroslav ; Hovořáková, Mária (advisor) ; Buchtová, Marcela (referee)
6 Abstract The development of the mouse tooth primordium is an important model for studying odontogenesis, as well as general organogenesis. The development of the mouse lower incisor is of remarkable interest. The epithelial anlage of the mouse lower incisor is interconnected with the vestibular anlage via the epithelial bridges. According to some authors, the epithelial bridges represent an area, where the transient rudimentary incisor germ appears. From a morphological point of view, the first sign of ongoing epithelial-mesenchymal interactions during early odontogenesis is the thickening of oral epithelium. From a molecular point of view, it is the expression of the Shh, Eda, Edar, Pitx2, Bmp2, Bmp4 and Dlx2 genes. Except for the transcription domain, representing the proper signalling centre of a developing prospective incisor, a transient transcription domain, localized anteriorly and superficially, appears in the odontogenic zone of the epithelium during early development. The anterior transcription domain originates in the area of epithelial bridges, and according to some authors, from an evolutionary point of view, it corresponds with the signalling centre of the rudimentary incisor germ. The aim of this diploma thesis was to compare the temporospatial dynamics of SHH and EDA protein expression in...
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Early tooth development of Tabby mice
Smrčková, Lucie ; Peterková, Renata (advisor) ; Černý, Robert (referee)
The developing mouse dentition is a very useful tool to study molecular regulation of odontogenesis and also organogenesis. The embryonic mouse dentition comprises developing functional tooth primordia as well as rudimentary tooth primordia. These rudiments arrest their growth during development and either degenerate or become a part of a functional tooth. Mice with gene defects also allow elucidation of a function of genes, their products and signalling pathways. The protein ectodysplasin is essential for development of ectodermal derivatives - skin, hair, glands and teeth. The Tabby mice have a mutation in the Eda gene, which encodes the protein ectodysplasin, and they display a number of dentition anomalies. Early development of the lower jaw dentition in Tabby embryos has been already morphologically described. As a prerequisite for understanding regulatory mechanisms of odontogenesis in Tabby mice, it is also necessary to map the spatiotemporal dynamics of signalling centres that express Shh in both the rudimentary and functional tooth primordia. The aim of this thesis was to compare the signalling centres based on the Shh expression and its spatiotemporal dynamics in the lower jaw of Tabby and WT mouse embryos. Then the Shh data were correlated with known morphological data to clarify the...
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