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Role fibroblastového aktivačního proteinu v růstu a invazivitě gliomových buněk
Fejfarová, Edita ; Bušek, Petr (advisor) ; Szabo, Pavol (referee)
High grade astrocytomas are very progressive brain tumors. Glioblastoma multiforme is the most frequent and the most malignant type with very infiltrative phenotype of the tumor cells. Fibroblast activation protein FAP is a predominantly membrane bound prolyl peptidase bearing exo- and endopeptidase hydrolytic activities. FAP is known to play a role in wound healing, cell migration and invasion and its expression is linked to the pathogenesis of several malignancies. mRNA expression of FAP is upregulated in 48% of glioblastomas according to The Cancer Genome Atlas microarray data. The involvement of FAP in the pathogenesis of astrocytic tumors is largely unknown. The aims of this work are to analyse the expression of FAP in primary cell cultures derived from high grade gliomas and to analyse the influence of FAP on the growth, migration and invasion of glioma cells. Our ELISA and western blot results showed heterogenous expression of FAP in the studied glioma primary cell cultures and cell lines. Both enzymatic activities characteristic of FAP were detected in the primary glioma cell culture P11 with high expression of FAP. In these cells, FAP was present not only in the typical plasma membrane localization, but also in the cytoplasm as demonstrated by immunofluorescence staining. The P11 cells...
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Postglacial vegetation history of local phenomena in western Bohemia
Švarcová, Markéta Gabriela ; Kuneš, Petr (advisor) ; Kozáková, Radka (referee)
In the sense of postglacial vegetation development, western Bohemia represents one of the least studied regions in the Czech Republic. This area, however, represents a supposed migration route of trees towards northern Europe during the Holocene. The most appropriate area for testing of such proposal might be western Sudetes with Slavkovský les protected landscape area in the Karlovy Vary region. Postglacial vegetation history was studied on the basis of two sedimentary profiles - from the fen bog near Číhanské prameny springs and from the vicinity of Mnichovské hadce serpentines from the nature reserve Mokřady pod Vlčkem. Percentual as well as influx diagrams were constructed on the basis of results of standard pollen analysis. Comparison of these results with the data from other suitable profiles enabled reconstruction of migration history of main tree taxa. The Číhaná profile reflects the period from the Older Dryas up to the Atlantic. The oldest Holocene forest was formed by the dominant Pinus, while Corylus was joining already in the Preboreal. Quercetum mixtum folowed in the begining of the Boreal and spruce quickly gained dominance in the Atlantic. The sedimentation process was probably finished due to rapid accumulation of sediments followed by spontaneous drainage ending with spruce and alder...
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The Relationships between Immigrants and the Authorities in the Czech Republic
Libichová, Lenka ; Šatava, Leoš (advisor) ; Tomandl, Miloš (referee)
This diploma thesis deals with the relationship between immigrants and the immigration authorities in the Czech Republic. The thesis is divided into two parts - theoretical and practical. The first one summarizes the facts about immigration authorities - the Ministry of the Interior of the Czech Republic, the Foreign Police and the Ministry of Foreign Affairs of the Czech Republic. It also discusses the causes of migration, the legal aspects and the non-governmental organizations that serves as a mediator between immigrants and the authorities. The practical part deals with the topic of immigrants and the authorities in the media and literature. It also includes a field resarch made by a qualitative method of directed interviews with the immigants, the representatives of non-governmental organizations and the representatives of the immigration authorities. The research is supplemented by an observations at Prague office of the Ministry of the Interrior. The most criticized problems of the Ministry of the Interrior is the failure to meet the statutory deadlines during the processing of applications for long-term stay, the behavior of officers and the queues of immigrants associated with a long waiting. The Ministry of Foreign Affairs has a problem with VISAPOINT - an internet operation system for...
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Counterurbanisation: rhytmus, identities, homes
Šimon, Martin ; Ouředníček, Martin (advisor) ; Čermák, Zdeněk (referee) ; Ptáček, Pavel (referee)
8 Abstract Counterurbanisation research, which is a central topic of this thesis, represents an appropriate field where transformations of contemporary societies and their socio- spatial organization can be examined. The dynamics of social and societal changes creates a demand for developing new methods and tools which helps us to understand contemporary change. Counterurbanisation is a multi-faceted concept which has been controversial since its initial use. An introduction of the concept of counterurbanisation in the field of population geography provoked a general debate on new and emerging trends in development of settlement system. Different logics of concentration and deconcentration of human activities has been challenged. Counterurbanisation operationalized as a migration poses a challenge for many standard conceptualizations of migration. The logic of non-economically motivated migration from the centre to the periphery requires a search for alternative explanatory mechanisms. Impact assessment and the impact of counterurbanisation in rural communities are analogous to the classical social science studies evaluating the integration of immigrants from rural areas in the cities. The thesis is composed of two basic sections. The first section presents a broader theoretical and methodological...
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The Czech Language and Refugees
Rakušanová, Anna ; Uherek, Zdeněk (advisor) ; Štěpánová, Irena (referee)
The thesis deals with the courses of the Czech language for refugees which are a part of The State Integration Program and which come under The Ministry of The Interior and The Ministry of Education, Youth and Sports. The thesis is aiming to characterize way the teaching is arranged, frequency of courses, what type of topics are widely discussed within and outside Integration Asylum Centers. Also, it is focusing on issues related to the courses of the Czech language for refugees. The thesis is based on terrain research, which should support the theoretical findings. The research was based on interviews with teachers of the Czech language and a social worker of Integration Asylum Centers both in Česká Lípa. It is also based on interviews with a coordinator of the language courses of Czech for refugees and a coordinator for technical and material support of the courses of the Czech language for refugees project. Keywords integration, migration, Czech language, refugees, Czech Republic
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Integration of Thai Migrants in Czechia
Šnajdr, Daniel ; Drbohlav, Dušan (advisor) ; Haišmanová, Lucie (referee)
This thesis analyzes the process of integration of Thai migrants into Czech society. The main aim is to explore the issue of Thai integration in Czech Republic by a quantitative research which haven`t been done fully in Czech Republic yet. Then on the basis of gained data to compare the state with another countries and to set the strategy of Thai integration in Czech Republic among the classic patterns of migrant behaviour or to identify the differences which could be specific only for Czech Republic. The thesis consists three main parts: theoretical, descriptive and practical. The introduction outlines the background of Thai migration. The theoretical framework, that follows, sets the gained information into theoretical concept of migration theories and defines important terms that accompany this thesis. Those analyzed information then help to evaluate the data gained by the practical part. The integral component of the thesis is descriptive part which outlines the development and reality of the investigated topic. The results of the questionnaire survey and interviews among Thai migrants in Czech Republic are presented in the practical part of this work. The conclusion establishes discourse between the theory and observed findings. There is also an assessment of the achieved results within the frame of...
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Comparative study of French and Spanisch approach towards imigration within the framework of Euro-Mediterranean Union
Straka, Vojtěch ; Romancov, Michael (advisor) ; Šánová, Lucie (referee)
This bachelor work deals withhistory and present of migration policy of France and Spain. Emphasis is put on the influence of the project Union for the Mediterenean, which has been introduced by former french president Nicolas Sarkozy as a continuation of Barcelon process, which had been lingering at the time. The work is observing the proces of creation of the Union for the Mediterenean. It briefly mentions wider political aspects of this creation but specifically put emphasis on its influence on migration policies of examined states. Important aspect which is playing a key role in migration policy of both states is process of creation of common european migration policy. This process and the treaties which started this process are also observed on thes pages. At the and this bachelor work summarizes what we've learned about migration policy of France and Spain, compares their approaches and briefly mentions possible future development.
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Integration of French persons living in Prague
Burianová, Anna ; Sládek, Jan (advisor) ; Šubrt, Jiří (referee)
Along with the migration of foreigners into the Czech Republic, the question of their integration into Czech society arises. The work focuses on the integration of French living in Prague. Based on 14 interviews the thesis analyzes their life with an emphasis on social integration, which is examined in terms of four dimensions: structural, cultural, interactive, and identifying. The thesis deals with theoretical concepts of migration and integration, which are related to the specific case of French. The aim of the thesis is to describe a way of integration and map the french community in Prague. Keywords: integration, social integration, migration, French, Prague
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Muslims in the Czech Republic: study of the integration process of the Arab minority in Czech environment
Vopelková, Veronika ; Uherek, Zdeněk (advisor) ; Zoufalá, Marcela (referee)
The aim of this work is to acquaint and understand the life of Arab Muslims in the Czech Republic. It also examines the rate of integration of Arab Muslims in various areas of life. For this purpose, a qualitative research was conducted in the form of 23 interviews with Arab Muslims, which concerned their reasons to stay in the Czech Republic, their socioeconomic situation, cultural determination, religious life and identity. In the concept of four dimensions of social integration, the author bases her information on the works of Wolfgang Bosswick and Friedrich Heckmann. First, basic terms necessary for understanding the issue are defined in the theoretical part. The second part represents the historical and legal context constituting conditions in the life of immigrants in the Czech Republic. The third part is fully devoted to qualitative synchronous research. Testimonies of Arabs are divided according to their planned length of stay in the Czech Republic and by individual dimensions of social integration, where the hypothesis is a direct proportionality between the intention to be in the Czech Republic for the rest of their lives and the level of integration into the Czech environment. An additional research dealing with the question of the activities of mosques and their roles in the life of...
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Integration of Foreigners in Prague, Capital of Czech Republic on the Example of the Pakistanis
Vlčková, Dominika ; Seidlová, Markéta (advisor) ; Janská, Eva (referee)
The aim of this thesis is to consider the integration of foreigners in the capital of the Czech Republic, with he focus on the Pakistani commuunity. The first part contains explanation of basic terms that are related to the integration of foreigners. Moreover, it includes description of integration policies. The second part focuses on characteristics of countries where the immigrants came from and also on mutual relations between country of emigration and country of immigration. The last, practical, part, which is the most important, is dedicated to research among members of the selected community and to problems of their integration into the dominant society on economical, social and cultural level.
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