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Atherosclerosis and cadiovascular risk in selected rheumatic diseases
Oreská, Sabína ; Tomčík, Michal (advisor) ; Horák, Pavel (referee) ; Soukup, Tomáš (referee)
Cardiovascular (CV) diseases due to atherosclerosis are the leading cause of morbidity and mortality worldwide. CV risk in rheumatic patients is caused by both traditional and non- traditional risk factors associated with autoimmune diseases. Unlike the relatively more prevalent rheumatic disease, there is a lack of evidence on CV risk in rare rheumatic diseases. The aim of this study was to evaluate the CV risk in 90 patients with idiopathic inflammatory myopathies (IIM), compared to 180 healthy controls (HC) with similar age and gender distribution, without clinically manifested CV diseases. The results of this cross-sectional cohort study showed a significantly higher prevalence of traditional risk factors as well as of subclinical atherosclerosis in IIM compared to HC. In comparison to carotid ultrasonography, SCORE, SCORE2, and modified SCORE was proved to underestimate the CV risk, while SCORE2 appeared to be the most accurate. The most severe CV risk profile was observed in patients with statin-induced necrotizing myopathy. Overall, higher CV risk in IIM was associated with higher age, disease activity, body composition parameters, and higher blood pressure values. We confirmed a higher CV risk as well as a higher prevalence of traditional risk factors in patients with IIM compared to the...
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Modeling Sound Field in Closed Space at Low Frequencies
Hořák, Pavel ; Kiska, Tomáš (referee) ; Schimmel, Jiří (advisor)
This diploma thesis deals with issues of low frequency acoustics and simulation. In this work the FTDT method of simulation is used. Measuring and simulation are focused on live-sound system and are evaluated using basic sound system optimisation techniques. Main output of this work is verification of basic low-frequency acoustics principles using simulation and measuring.
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Credit Limit Management and Credit Application
Horák, Pavel ; Hebelka, Ivo (referee) ; Zeman, Václav (advisor)
The thesis deals with the bank credit risk over enterpreneurial subject with double-entry accounting system. The monitoring of possibilities to acquire the bank credit for future business development is based on operating results. The requisition for the bank credit is being prepared also with for the component for the bank providing the credit.
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Measurement of the reverberation time
Hořák, Pavel ; Ryndová, Anna (referee) ; Jedelský, Jan (advisor)
This bachelor thesis deals with issues concerning measuring of reverberation time in closed rooms. Two evaluation methods are described in this thesis; integrated impulse response method and interrupted noise method. Data were recorded with the aid of acoustic module Photon+ and RT Pro 7.1. software. Practical part comprises implementation of evaluation programme in Matlab environment. Computation of reverberation curves is a major output of the thesis. Individual methods are compared on the basis of discovered figures.
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Reporting of the Selected Company
Drábková, Adéla ; Horák, Pavel (referee) ; Hanušová, Helena (advisor)
The thesis deals with reporting. The first part is theoretically explained the concept of reporting, as one of the basic functions of controlling, PEST analysis, Porter's five forces model, 7S analysis and SWOT analysis. The practical part is focused on the analysis of the situation in reporting and follow-up proposals to improve the situation.
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Václav Majer and the Social Democratic Party. The Fortunes of the Leading Figure of One Stream within the Czechoslovak Social Democracy
Brož, Jan ; Kocian, Jiří (advisor) ; Zahradníček, Tomáš (referee) ; Horák, Pavel (referee)
The present thesis deals with the political career of a Social Democratic politician Václav Majer. No specialized paper has so far been dedicated to his fifty-year-lasting career, even though his position in history of the Czechoslovak Social Democratic Party is far from negligible. Václav Majer is particularly known as a leader of the "right"/anti-communist wing within the Social Democratic Party during a short spell of Czechoslovak history from 1945 to 1948 (so-called Third Republic). However, he had started his career much earlier at the beginning of the First Czechoslovak Republic in Louny District. In mid-thirties he had moved to Prague and kept on working after the Munich Agreement was signed, and during the Protectorate as well. At the beginning of 1940 he emigrated to the United Kingdom. During the Second World War he has started his career in high level exile politics in London. After the Communist coup d'état in 1948, which had ended the period of the Third Republic, Majer left Czechoslovakia again. He lived and worked in exile till his death. Attention is paid to Majer's position on political scene and to development of his relations with other political actors. My research is based on study of archival documents, as well as study of specialized books, memoirs, newspapers and periodicals.
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Pathophysiological and genetic factors affecting serum uric acid level.
Hasíková, Lenka ; Závada, Jakub (advisor) ; Hrnčíř, Zbyněk (referee) ; Horák, Pavel (referee)
Introduction: Serum uric acid level (SUA) depends on the balance between its production and excretion. SUA is associated with several transmembrane proteins responsible for reabsorption (mainly URAT1 and GLUT9) and secretion (ABCG2) on the apical and basolateral membranes of the proximal tubules in the kidney, and in the case of ABCG2, it also correlates with its significant excretion through the gastrointestinal tract. Gout is a metabolic disease caused by the deposition of urate crystals in the joints and tissues. Chronic hyperuricemia is a primary risk factor for the development of gout; however, gout patients usually have a lower SUA during an acute gout attack than in the intercritical periods. The exact mechanism of this phenomenon is unknown. It has been speculated that the systemic inflammatory response can explain this discrepancy. The aim of the study is to determine whether treatment with specific inhibitors of the proinflammatory cytokine TNF (TNFi) affects SUA in patients with systemic rheumatic disease (SRD), and whether changes in SUA correlate with changes in selected proinflammatory cytokines or with the biomarker of oxidative stress, allantoin. Another aim is to determine the frequency and effect of allelic variants in the ABCG2 urate transporter gene in patients with primary...
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