Original title:
Enzymatic synthesis of ester prodrugs of DHPA and related compounds by lipases
Authors:
Blažek, Jiří ; Kaiser, M. M. ; Zarevúcka, Marie ; Králová, B. ; Krečmerová, Marcela Document type: Papers Conference/Event: Chemistry of Nucleic Acid Components /15./, Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year:
2011
Language:
eng Abstract:
An enzymatic method was used for esterification of DHPA and related compounds with vinyl esters and catalyzed by different lipases in non-aqueous media (DMF). Esters of DHPA and other compounds could be synthesized and purified in satisfactory yields.
Keywords:
DHPA; ester prodrugs; lipases; transesterification; vinyl esters Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP) Funding provider: GA MŠk Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0198529