Original title:
Melectin analogues: The influence of dendrimerization on antimicrobial and hemolytic activity
Authors:
Niederhafner, Petr ;
Šafařík, Martin ;
Ježek, Jan ;
Borovičková, Lenka ;
Bednárová, Lucie ;
Fučík, Vladimír ;
Čeřovský, Václav ;
Slaninová, Jiřina
Document type: Papers
Conference/Event: Biologically Active Peptides. Conference /11./ , Praha (CZ), 2009-04-22 / 2009-04-24
Year:
2009
Language:
eng
Abstract:
Dimers and tetramers of MEP and MEP derivatives were synthesized on Fmoc-Lys(Fmoc)-Rink amide resin, the tetramer was obtained from the dimer C-terminally extended via Cys-Cys linkage. In general, the dendrimerization of MEP led to an increase of haemolytic activity but did not improve substantially its antimicrobial properties.
Keywords:
antibacterial peptides ;
dendrimers ;
hemolytic activity ;
MAPs
Project no.: CEZ:AV0Z40550506 (
CEP ),
GA203/03/1362 (
CEP )
Funding provider: GA ČR
Host item entry: Biologically Active Peptides. 11th Conference, ISBN 978-80-86241-31-9
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(
web )
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0181975
Permalink: http://www.nusl.cz/ntk/nusl-41219
The record appears in these collections: Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry Conference materials > Papers