Original title: Melectin analogues: The influence of dendrimerization on antimicrobial and hemolytic activity
Authors: Niederhafner, Petr ; Šafařík, Martin ; Ježek, Jan ; Borovičková, Lenka ; Bednárová, Lucie ; Fučík, Vladimír ; Čeřovský, Václav ; Slaninová, Jiřina
Document type: Papers
Conference/Event: Biologically Active Peptides. Conference /11./, Praha (CZ), 2009-04-22 / 2009-04-24
Year: 2009
Language: eng
Abstract: Dimers and tetramers of MEP and MEP derivatives were synthesized on Fmoc-Lys(Fmoc)-Rink amide resin, the tetramer was obtained from the dimer C-terminally extended via Cys-Cys linkage. In general, the dendrimerization of MEP led to an increase of haemolytic activity but did not improve substantially its antimicrobial properties.
Keywords: antibacterial peptides; dendrimers; hemolytic activity; MAPs
Project no.: CEZ:AV0Z40550506 (CEP), GA203/03/1362 (CEP)
Funding provider: GA ČR
Host item entry: Biologically Active Peptides. 11th Conference, ISBN 978-80-86241-31-9

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0181975

Permalink: http://www.nusl.cz/ntk/nusl-41219


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers