Original title: Following the phenotype development of TgHD minipigs by invasive and noninvasive approach
Authors: Ellederová, Zdeňka ; Baxa, Monika ; Vidinská, Daniela ; Bohuslavová, Božena ; Vochozková, Petra ; Šmatlíková, Petra ; Klíma, Jiří ; Valeková, Ivona ; Ardan, Taras ; Juhás, Štefan ; Juhásová, Jana ; Konvalinková, R. ; Klempíř, J. ; Pokorný, M. ; Krupička, R. ; Kauler, J. ; Hansíková, H. ; Motlík, Jan
Document type: Papers
Conference/Event: Animal Models of Neurodegenerative Diseases /4./, Liblice (CZ), 20171022
Year: 2017
Language: eng
Abstract: Recent promising treatments for Huntington’s disease (HD) may require pre-clinical testing in large animals. In 2009, we generated HD transgenic (TgHD) minipigs with one copy encoding the N-terminal part (548 aa) of human huntingtin (HTT) with 124 CAG/CAA repeats integrated into chromosome 1 q24-q25. The successful germ line transmission occurred through four successive generations.
Keywords: Huntington´s disease; minipigs
Project no.: LO1609 (CEP)
Funding provider: GA MŠk
Host item entry: The 4th Animal Models of Neurodegenerative Diseases

Institution: Institute of Animal Physiology and Genetics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0280254

Permalink: http://www.nusl.cz/ntk/nusl-371510


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Research > Institutes ASCR > Institute of Animal Physiology and Genetics
Conference materials > Papers