Original title:
Following the phenotype development of TgHD minipigs by invasive and noninvasive approach
Authors:
Ellederová, Zdeňka ;
Baxa, Monika ;
Vidinská, Daniela ;
Bohuslavová, Božena ;
Vochozková, Petra ;
Šmatlíková, Petra ;
Klíma, Jiří ;
Valeková, Ivona ;
Ardan, Taras ;
Juhás, Štefan ;
Juhásová, Jana ;
Konvalinková, R. ;
Klempíř, J. ;
Pokorný, M. ;
Krupička, R. ;
Kauler, J. ;
Hansíková, H. ;
Motlík, Jan
Document type: Papers
Conference/Event: Animal Models of Neurodegenerative Diseases /4./ , Liblice (CZ), 20171022
Year:
2017
Language:
eng
Abstract:
Recent promising treatments for Huntington’s disease (HD) may require pre-clinical testing in large animals. In 2009, we generated HD transgenic (TgHD) minipigs with one copy encoding the N-terminal part (548 aa) of human huntingtin (HTT) with 124 CAG/CAA repeats integrated into chromosome 1 q24-q25. The successful germ line transmission occurred through four successive generations.
Keywords:
Huntington´s disease ;
minipigs
Project no.: LO1609 (
CEP )
Funding provider: GA MŠk
Host item entry: The 4th Animal Models of Neurodegenerative Diseases
Institution: Institute of Animal Physiology and Genetics AS ČR
(
web )
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0280254
Permalink: http://www.nusl.cz/ntk/nusl-371510
The record appears in these collections: Research > Institutes ASCR > Institute of Animal Physiology and Genetics Conference materials > Papers