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Optimizing Image Reconstruction in Electrical Impedance Tomography
Dušek, Jan ; Brančík, Lubomír (referee) ; Sikora, inž Jan (referee) ; Mikulka, Jan (advisor)
Tato disertační práce pojednává o optimalizaci algoritmů pro rekonstrukci obrazu neznámé měrné vodivosti z měřených dat pořízených elektrickou impedanční tomografií. Danou problematiku zde věcně vymezuje několik různých prvků, zejména pak stručný matematický popis dopředné a inverzní úlohy řešené různými přístupy, metodika měření a pořizování dat pro rekonstrukci a přehled dostupných numerických nástrojů. Uvedenou charakteristiku rozšiřuje rozbor optimalizací parametrů modelu ovlivňujících přesnost rekonstrukce, způsoby paralelního zpracování algoritmů a souhrn dostupných zařízení pro měření tomografických dat. Na základě získaných poznatků byla navržena optimalizace parametrů matematického modelu, která umožňuje jeho velmi přesný návrh dle měřených dat. V této souvislosti dochází ke snížení nejistoty rekonstrukce rozložení konduktivity. Pro zefektivnění procesu získávání dat bylo navrženo zařízení k automatizaci tomografie s důrazem na cenovou dostupnost a snížení nejistoty měření. V oblasti tvorby numerického modelu byly dále zkoumány možnosti užití otevřených a uzavřených domén pro různé metody regularizace a hrubost sítě, a to s ohledem na velikost chyby rekonstruované konduktivity a výpočetní náročnost. Součástí práce je také paralelizace subalgoritmů rekonstrukce s využitím vícejádrové grafické karty. Předložené výsledky mají přímý vliv na snížení nejistoty rekonstrukce (optimalizací počáteční hodnoty konduktivity, rozmístění elektrod a tvarové deformace domény, regularizačních metod a typu domén) a urychlení výpočtů paralelizací algoritmů, přičemž výzkum byl podpořen vlastním návrhem jednotky pro automatizaci tomografie.
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Control of reactive magnetron sputtering
Dušek, Jan ; Boušek, Jaroslav (referee) ; Ing. Tomáš Fořt, Ph.D., ÚPT AVČR, Brno (advisor)
Bachelor's thesis concisely describes technology of reactive magnetron sputtering and deals with the design and realization of controlling program. For this purpose it was created the control program for steering of individual components of apparatus PLS 160 in programming enviroment Labview. On basis of the knowledge of technological process and procedures of reactive magnetron sputtering the automatic program was created. This program can be modified using recipes. Besides program structures mechanical and electrical changes of apparatus were made. The entire automated process was tested.
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Road Sign Detection from Camera in Car
Dušek, Jan ; Sochor, Jakub (referee) ; Beran, Vítězslav (advisor)
This bachelor's thesis is focused on detection of traffic signs from image or video. Algorithms common for object detection will be introduced in the beginning. Description of object detection using histogram of oriented gradients and support vector machines will follow. Last part will present accomplished results.
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Firesport stopwatch
Drška, Jan ; Drexler, Petr (referee) ; Dušek, Jan (advisor)
The goal of the bachelor thesis is to design, construct and test a timer for fire sport including a large display and automatic targets. The thesis includes a market research around commercially available timing devices, their comparison with each other according to available parameters, and finally a system is designed and constructed that combines the capabilities of already manufactured sets with new features and possibilities for large-scale extension beyond the boundaries of fire sport.
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Reactive sputtering Al2O3
Dušek, Jan ; Boušek, Jaroslav (referee) ; Fořt, Tomáš (advisor)
Diploma thesis describes technology of pulse reactive magnetron sputtering of Al2O3 coating. Furthermore it deals with design of deposition process and testing new aluminium target. The technological window was determined by tests. As a result, it was possible to create Al2O3 coatings in the widest possible working range. The coatings created by apparatus PLS 160 were tested for optical properties in order to obtain transmittance. Besides the optical tests, the evaluation of mechanical properties and adhesion were performed. The obtained results from measurement were evaluated. Based on the results, some possible applications of the coating were suggested.
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Reflexes of laryngeals in the Akkadian loanwords from the West-Semitic Languages in the 1st millenium BCE
Dobrota, Andrej ; Zemánek, Petr (advisor) ; Dušek, Jan (referee)
The aim of this work is to determine the patterns used by the speakers of Akkadian to adapt laryngeal phonemes in loanwords from West-Semitic languages by analysing the reflexes of these phonemes in the Akkadian words. Corpus used for analysis is taken mainly from already existing lists of West-Semitic loanwords in Akkadian (von Soden 1966, 1968, 1977; Cherry 2017; Zadok 2021, 2022) subsequently reduced using criteria based on Abraham - Sokoloff (2011) and supplemented by additional lexemes (mainly from CAD). The results of this analysis are further corroborated by analysing transcriptions of West-Semitic personal names occurring in RINAP 1 - 5 containing laryngeals into cuneiform. Findings of these analyses are then presented in the final part of the work. It was possible to determine quite unambiguously the individual patterns of adaptation of the respective laryngeal phonemes. Original /ḥ/ and /ḫ/ were adapted as /ḫ/, original /ˤ/ and /ˀ/ as /ˀ/ or ∅, depending on its position. Original /h/ and /ġ/ were not present in the studied corpus, thus precluding any possibility of determining their adaptation patterns. The results of this work may be applied to better understand strategies employed by Akkadian speakers in adapting loanwords and they give a systematic survey of these patterns when applied...
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Vyhodnocení růstu a zdravotního stavu telat v závislosti na různých chovatelských podmínkách
DUŠEK, Jan
The goal of every livestock farmer should be a viable, well-growing healthy calf that passes on its genetic information to future generations. This thesis deals with the impact of growth and health of calves depending on the selected breeding technology in chosen farm of Holstein cattle. The aim was to compare various ways of housing calves in operating conditions. The chosen hypothesis predicts to achieve better results of calves housed in an individual system (VIB) compared to a group system (VSB). In 2020 a group of calves (n 41), divided evenly into various housing systems (individual /group), was monitored in the selected farm. The experiment lasted from the birth to the 85th day. Based on the results of the experiment, the calves of both observed groups received quality colostrum (average value of 26.17 % Brix) in the sufficient amount (average amount at the first drink 3.45 l). Calves are not weighed at birth in this farm (calves are assigned a value of 30 kg, regardless of sex). The average measured birth weight was 38.4 kg. It would be good to adjust this value in the in-house system to reflect reality better. On the basis of the results of observations, the original hypothesis can be rejected. There was no statistically significant difference between the two groups of calves when compared. It is not possible to confirm / exclude the degree of susceptibility of individual groups of calves to infectious pressures and diseases objectively (statistically) due to a small number of observations. Diarrheal diseases were more serious problem. These diseases occurred most in calves up to one month of their age, with a disease prevalence of 25 % and an average mortality of 7,4 %. No statistically significant difference was found when weight gains were compared. Weaned calves of the VIB housing system showed higher profitability, on average CZK 313 per calf, CZK 2.92 per kg of weight gain. From the point of view of animal welfare, there were problems with scraped backs of the calves housed in plastic sheds (Calf - Tel) because of their height at the shoulder. These sheds had a low entryway (95 cm). In the farm, the milk fed calves are fed from free surface; the teats are not used here. It would be worth considering and testing whether a change of a calf feeding method had a positive effect on the prevalence of diarrheal diseases. This could lead not only to a reduction in costs of potential veterinary care and medicine, but also to an increase in weight gain and thus to higher economic yields.
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Development of novel Constitutive androstane receptor (CAR) ligands
Dušek, Jan ; Pávek, Petr (advisor) ; Hudeček, Jiří (referee) ; Chládek, Jaroslav (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate Mgr. Jan Dušek Supervisor Prof. PharmDr. Petr Pávek, Ph.D. Title of Doctoral Thesis Development of novel Constitutive androstane receptor (CAR) ligands Constitutive androstane receptor is nowadays known as the established nuclear receptor that regulates the expression of several key cytochrome P450 enzymes, predominantly CYP3A4 and CYP2B6. Recently it has been shown that CAR has also essential role in the regulation of endogenous metabolism of glucose, lipids, cholesterole or bile acids. Simultaneously, this receptor is considered to have proliferative effect on human hepatocytes and protective effects against toxic and dietary damage of liver parenchyme. Given the possible therapeutic utilization of CAR, its therapeutic options are being intensively studied. Unfortunately, currently known ligands of human or mouse CAR are either poorly selective or indirect. The aim of my doctoral thesis was to find new ligands of mouse and human CAR, that would enable more detailed study of the receptor.
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