Název: Comparison of microbial interactions of zinc oxide nanomaterials in various size and shape
Autoři: Rutherford, D. ; Jíra, J. ; Mičová, J. ; Remeš, Zdeněk ; Hsu, H.S. ; Rezek, B.
Typ dokumentu: Příspěvky z konference
Konference/Akce: Nanocon 2019 International Conference on Nanomaterials - Research & Application /11./, Brno (CZ), 20191016
Rok: 2020
Jazyk: eng
Abstrakt: Zinc oxide nanoparticles (ZnO NP) have shown great potential as a novel antibacterial material at a time when resistance towards conventional antibiotics is becoming more prevalent. We report bacteria inactivation by ZnO NP with novel hedgehog-like morphology using model gram-negative (E. coli) and gram-positive (S. aureus) bacteria. E. coli exposed to the novel ZnO hedgehog NP during growth resulted in 4 orders of magnitude reduction in viable cell concentration after 24 h, which is more than 2 orders higher reduction compared to commercially available ZnO NPs with nominal sizes from 50 nm to 20 um. There was a positive correlation between hedgehog NP concentration and bacteria cell concentration reduction within the range tested 0.1 – 1.0 mg/mL. S. aureus was less sensitive to ZnO NP exposure and inactivation effect of various ZnO NP, was comparable. The effect can be thus attributed to direct mechanical damage of the bacterial mebrane that is the most effective for the novel hedgehog ZnO NP. This conclusion was corroborated also by disk diffusion assays.\n
Klíčová slova: microbiology; nanotechnology; zinc oxide
Číslo projektu: GC19-02858J (CEP)
Poskytovatel projektu: GA ČR
Zdrojový dokument: Nanocon 2019 : Proceedings of the International Conference on Nanomaterials - Research & Application /11./, ISBN 978-80-87294-95-6

Instituce: Fyzikální ústav AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0316924

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-432392


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Fyzikální ústav
Konferenční materiály > Příspěvky z konference