Název: Influence of inhaled manganese oxides nanoparticles on mass of internal organs in mice
Autoři: Zeman, T. ; Dočekal, Bohumil ; Mikuška, Pavel ; Buchtová, Marcela ; Míšek, Ivan ; Šerý, Omar ; Večeřa, Zbyněk
Typ dokumentu: Příspěvky z konference
Konference/Akce: NANOCON International Conference /6./, Brno (CZ), 2014-11-05 / 2014-11-07
Rok: 2014
Jazyk: eng
Abstrakt: Results of the statistical analysis of a long-term inhalation experiment on laboratory mice are presented. During 17 weeks of the experiment, the experimental group was exposed to inhaled manganese oxides nanoparticles. Manganese oxides (MnO center dot Mn2O3) nanoparticles (MnONPs) were synthesized continuously via aerosol route in a hot wall tube flow reactor using a thermal decomposition of metal organic precursor manganese(II) acetylacetonate in the flow tube reactor (in vertical position) at temperature 750 degrees C in the presence of 30 vol% of oxygen. The concentration of produced MnONPs at the reactor output was in the range 1-3 x 10(7) particles/cm(3) and the size of generated nanoparticles MnO center dot Mn2O3 was in the range 7-50 nm. Before entering the inhalation chamber, MnONPs in the mixture of N-2, O-2 and air (at total flow rate of 3 L/min) were further diluted using filtrated humidified air (20 L/min) at temperature 21 degrees C resulting in the MnONPs concentration 2 x 10(6) particles/cm(3). At regular time intervals the mass of selected internal organs of mice from both experimental and control group was assessed. It has been proven that inhaled nanoparticles are able to influence the mass of internal organs of mice. Statistically significantly lower mass of kidneys, liver and spleen and higher mass of pancreas have been found in the experimental group compared to the control group.
Klíčová slova: changes in internal organ mass of mice; inhaled nanoparticles; long-term inhalation experiment; manganese oxides nanoparticles
Číslo projektu: GBP503/12/G147 (CEP), GAP503/11/2315 (CEP)
Poskytovatel projektu: GA ČR, GA ČR
Zdrojový dokument: NANOCON 2014, 6th International Conference, ISBN 978-80-87294-53-6

Instituce: Ústav analytické chemie AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný na vyžádání prostřednictvím repozitáře Akademie věd.
Původní záznam: http://hdl.handle.net/11104/0247920

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-188997


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Ústav analytické chemie
Konferenční materiály > Příspěvky z konference