Original title: Influence of inhaled manganese oxides nanoparticles on mass of internal organs in mice
Authors: Zeman, T. ; Dočekal, Bohumil ; Mikuška, Pavel ; Buchtová, Marcela ; Míšek, Ivan ; Šerý, Omar ; Večeřa, Zbyněk
Document type: Papers
Conference/Event: NANOCON International Conference /6./, Brno (CZ), 2014-11-05 / 2014-11-07
Year: 2014
Language: eng
Abstract: Results of the statistical analysis of a long-term inhalation experiment on laboratory mice are presented. During 17 weeks of the experiment, the experimental group was exposed to inhaled manganese oxides nanoparticles. Manganese oxides (MnO center dot Mn2O3) nanoparticles (MnONPs) were synthesized continuously via aerosol route in a hot wall tube flow reactor using a thermal decomposition of metal organic precursor manganese(II) acetylacetonate in the flow tube reactor (in vertical position) at temperature 750 degrees C in the presence of 30 vol% of oxygen. The concentration of produced MnONPs at the reactor output was in the range 1-3 x 10(7) particles/cm(3) and the size of generated nanoparticles MnO center dot Mn2O3 was in the range 7-50 nm. Before entering the inhalation chamber, MnONPs in the mixture of N-2, O-2 and air (at total flow rate of 3 L/min) were further diluted using filtrated humidified air (20 L/min) at temperature 21 degrees C resulting in the MnONPs concentration 2 x 10(6) particles/cm(3). At regular time intervals the mass of selected internal organs of mice from both experimental and control group was assessed. It has been proven that inhaled nanoparticles are able to influence the mass of internal organs of mice. Statistically significantly lower mass of kidneys, liver and spleen and higher mass of pancreas have been found in the experimental group compared to the control group.
Keywords: changes in internal organ mass of mice; inhaled nanoparticles; long-term inhalation experiment; manganese oxides nanoparticles
Project no.: GBP503/12/G147 (CEP), GAP503/11/2315 (CEP)
Host item entry: NANOCON 2014, 6th International Conference, ISBN 978-80-87294-53-6

Institution: Institute of Analytical Chemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0247920

Permalink: http://www.nusl.cz/ntk/nusl-188997

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Research > Institutes ASCR > Institute of Analytical Chemistry
Conference materials > Papers
 Record created 2015-07-30, last modified 2018-07-30

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