Ústav experimentální medicíny

Nejnovější přírůstky:
2011-07-04
07:48
Modeling of nucleolar self-assembly
Blažíková, Michaela ; Heřman, P. ; Malínský, Jan
Mammalian cell nucleoli disassemble at the beginning of mitosis and reassemble again during telophase and the early G1. Dynamics of this process was studied using a model based on entropy driven self-assembly of pre-ribosomal particles generated in a single biosynthetic source. Monte Carlo simulations revealed that such model can explain formation of a large aggregate, a nucleolus, in the vicinity of the source. We examined influence of nucleoplasm properties on dynamics of the aggregate formation.

Úplný záznam
2011-07-01
17:03
Nanotechnologies in regenerative medicine
Syková, Eva
Magnetic resonance imaging provides a noninvase method to study the fate of transplanted cells in vivo. Various biocomatible scaffolds based on non-woven nanofibres (products of ELMARCO or Technical University Liberec), have been developed for bridging tissue defects and for use as 3D stem cell careiers.

Úplný záznam
2011-07-01
17:03
NANOTECHNOLOGY AND BIOMATERIALS IN MEDICINE
Kubinová, Šárka ; Jendelová, Pavla ; Lesný, Petr ; Holáň, Vladimír ; Syková, Eva
Our studies focus on the use of nanotechnology in cell therapy and tissue engineering for the treatment of brain and spinal cord injury, corneal defects and chronic wounds.

Úplný záznam
2011-07-01
16:54
Diffusion properties of the brain in health and disease
Syková, Eva
Diffusion parameters affect neurone-glia communication, ionic homeostasis, the movement and accumulation of neuroactive substances and, therefore, play an important role in synaptic as well as volume transmission.

Úplný záznam
2011-07-01
16:54
Human embryonic stem cell line originating from blastocyst produced by intracytoplasmic sperm injection
Hampl, Aleš ; Jendelová, Pavla ; Syková, Eva ; Dvořák, Petr
The biological properties of the AL1 ES cell line will be assessed by introducing the cells into the brains of adult Wistar rats following a unilateral cortical photochemical lesion.

Úplný záznam
2011-07-01
16:54
MR tracking of transplanted stem cells labeled by iron-oxide nanoparticles
Syková, Eva ; Jendelová, Pavla
Our study demonstrates that grafted MSC and ESC migrate into an injured brain region. The commercially available contrast agent Endorem, based on iron-oxide nanoparticles, can be used a marker for long-term noninvasive MR tracking of implanted stem cells.

Úplný záznam
2011-07-01
16:54
Changes in intrinsic optical signals and extracellular space diffusion parameters. Do they have a common mechanism?
Chvátal, Alexandr ; Vargová, Lýdia ; Kubinová, Šárka ; Syková, Eva
We can therefore conclude that light transmittance changes do not simply correlate with changes in ECS volume, but they are clearly associated with neuronal activity accompanied by various biochemical, biophysical and morphological changes.

Úplný záznam
2011-07-01
16:54
Role of glial cells in extrasynaptic communication
Syková, Eva
It is evident that during neuronal activity and pathological states, the movement of substances in the brain is not only hindered by the size of the pores between the cells, but also by the structure of the glial cells. These changes, together with K+ and pH changes in the ECS, affect the efficacy of interneuronal and neurone-glia communication.

Úplný záznam
2011-07-01
16:54
Implantation of bone marrow stromal cells labeled with superparamagnetic nanoparticles into injured brain and imaging their fate by magnetic resonance
Jendelová, Pavla ; Herynek, V. ; Glogarová, Kateřina ; Hájek, M. ; Syková, Eva
Our study demonstrates that MSCs only migrate into an injured brain region. The commercially available contrast agent Endorem can be used as a cell marker for noninvasive MR tracking of implanted stem cells.

Úplný záznam
2011-07-01
16:54
Stem cells and therapy of brain and spinal cord injury
Syková, Eva ; Jendelová, Pavla ; Glogarová, Kateřina ; Urdzíková, Lucia ; Lesný, Petr ; Hampl, Aleš ; Dvořák, Petr
Our studies demonstrate the potential of SC as a therapeutic tool in the treatment of injury and degenerative diseases, explain the effects of certain drugs on neurogenesis and regeneration and show that there may be various ways in which SC may interact with the host CNS tissue.

Úplný záznam